Level of biogenic amines in pregnant women with psycho-emotional disorders stipulated by anxiety

Authors

  • V. G. Syusyuka Zaporizhzhia State Medical University, Ukraine,

DOI:

https://doi.org/10.14739/2310-1237.2017.3.118755

Keywords:

pregnancy, psychoemotional state, anxiety, biogenic amines

Abstract

Object of research to determine level of biogenic amines in pregnant women with psycho-emotional disorders stipulated by anxiety. 

Group of examined women and methods of research. 90 Pregnant women were examined in ІІ and ІІІ trimester of pregnancy. The main group includes 58 pregnant women with the medium and high level of state anxiety and 32 pregnant women with anxiety level of 30 points and less that indicates the low level of SA (control group). For estimation of the state anxiety and trait anxiety the scale of Spielberger-Hanin was used. Level of serotonin and melatonin was measured with fluorometric method in blood hemolysate of pregnant women.

Results. According to the obtained results of biochemical research of hemolysate of packed red cells of blood of examined women it was stated that increase of state anxiety was accompanied by statistically reliable  (p < 0.05) rise of serotonin level and decrease of melatonin level. Thus, special features have direct influence on increase (p < 0.05) of serotonin/melatonin index. Pregnant women of the main group have the index which was 2.5 times higher than the same index in women of the control group.  

Conclusions. Results of performed research among pregnant women have indicated that increase of state anxiety is accompanied by statistically reliable (p < 0.05) rise of serotonin content in blood and statistically reliable (p < 0.05) decrease of melatonin. Such results have direct influence on increase (p < 0.05) of serotonin/melatonin index in pregnant women with medium and high levels of state anxiety comparing to the certain index in women with the low level of anxiety.

References

Aleksandrovskij, Yu. A., Poyurovskij, M. V., & Neznamov, G. G. (1991). Nevrozy i perekisnoe okislenie lipidov [Neuroses and lipid peroxidation]. Moscow: Nauka. [in Russian].

Anisimov, V. N.,. & Vinogradova, I. A. (2008). Starenie zhenskoj reproduktivnoj sistemy i melatonin [Aging of the female reproductive system and melatonin]. Saint Petersburg: Sistema. [in Russian].

Chekman, I. S., Belenichev, I. F., Gorchakova, N. A., Kucherenko, L. I., Bukhtiyarova, N. V., & Pogotova, G. A. (2014). Antioksidanty: kliniko-farmakologicheskij aspekt [Antioxidants: clinical and pharmacological aspects]. Ukrainskyi medychnyi chasopys, 1(99), 22–28. [in Russian].

Astakhov, V. M., Bacyleva, O. V., & Puz', I. V. (2016). Psikhodiagnostika v reproduktivnoj medicine [Psychodiagnostics in reproductive medicine]. Vinnica: Nilan-LTD. [in Ukrainian].

Baraboj, V. A., & Sutkovoj, D. A. (1997). Okislitel'no-antioksidantnyj gomeostaz v norme i patologii [Oxidative-antioxidant homeostasis in norm and pathology]. Kyiv: Chernobyl'interinform. [in Russian].

Hryban, V. H. (2008). Valeologіya [Valeology]. Kyiv: Centr uchbovoi lіteratury. [in Ukrainian].

Gutikova, L. V., & Bubeshko, D. A. (2014). Rol' biogennykh aminov v realizacii reproduktivnoj funkcii organizma [Role of biogenic amins in realization of reproductive function of organism]. Zhurnal Grodnenskogo gosudarstvennogo medicinskogo universiteta, 2, 5–9. [in Russian].

Dadambaev, E. T. (1986). Fluorimetricheskij metod opredeleniya melatonina krovi [Fluorimetric method for determination of melatonin of blood]. Laboratornoe delo, 1, 30–32. [in Russian].

Grishhenko, V. I., Lipko, O. P., Rubinskaya, T. V., Potapova, L. V., & Shherbina, I. N. (2004) Novye podkhody k issledovaniyu patogeneza i diagnostike pregestoza [New approaches to the study of pathogenesis and diagnosis of preterest]. Mezhdunarodnyj medicinskij zhurnal, 3, 114–116. [in Russian].

Rogova, N. A., Botasheva, T. L., Avrutskaya, V. V., Kaushanskaya, L. V., & Frolov, A. A. (2013) Osobennosti melatoninovogo obmena i gormonal'nogo statusa zhenshhin v zavisimosti ot lateralizacii placenty v predrodovom periode v razlichnye sezony goda [Peculiarities of melatonin exchange and hormonal status of women in dependence on placental lateralization in preterm period in different seasons of the year]. Sovremennye problemy nauki i obrazovaniya, 4, 152. [in Russian].

Yudenfrend, S. (1965). Fluorescentnyj analiz v biologii i medicine [Fluorescence analysis in biology and medicine]. Moscow: Mir. [in Russian].

Sumrach, M. U., Bogdan, O. G., & Sinitskaya, A. V. (2012). Uroven' trevozhnosti zhenshhiny vo vremya beremennosti i mediko-social'nye faktory, vliyayushhie na nego [Level of anxiety in pregnant woman, medical and social factors influencing it]. Vestnik Smolenskoj gosudarstvennoj medicinskoj akademii, 2, 12–18. [in Russian].

Furs, V. V., & Doroshenko, E. M. (2011). Nekotorye pokazateli obmena triptofana pri fiziologicheski protekayushhej beremennosti [Tryptophan metabolism rates in physiological pregnancy]. Zhurnal Grodnenskogo gosudarstvennogo medicinskogo universiteta, 4, 36–38. [in Russian].

Furs, V. V. (2010). Rol' biogennykh aminov pri beremennosti, oslozhnyonnoj placentarnoj nedostatochnost'yu [Role of biogene amins in pregnancy complicated by placental insufficiency]. Zhurnal Grodnenskogo gosudarstvennogo medicinskogo universiteta, 4, 12–16. [in Russian].

Arjanova, O. N., Kvetnoy, I. M., Kuznecova, A. V., & Kolobov, A. V. (2006). E´kspressiya biogennykh aminov pri placentarnoj nedostatochnosti Biogenic Amines Expression In Placental Insufficiency]. Zhurnal akusherstva i zhenskih boleznej, LV(1), 44–49. [in Russian].

Reiter, R. J., Tan, D. X., Jou, M. J., Korkmaz, A., Manchester, L. C., & Paredes, S. D. (2008). Biogenic amines in the reduction of oxidative stress: melatonin and its metabolites. Neuro Endocrinol Lett., 29(4), 391–8.

Duhig, K. Chappell, L. C., & Shennan, A. H. (2016). Oxidative stress in pregnancy and reproduction. Obstet Med., 9(3), 113–6. doi: 10.1177/1753495X16648495

Tan, D. X., Manchester, L. C., Esteban-Zubero, E., Zhou, Z., & Reiter, R. J. (2015). Melatonin as a Potent and Inducible Endogenous Antioxidant: Synthesis and Metabolism. Molecules, 20(10), 18886–906. doi: 10.3390/molecules201018886.

Reiter, R. J., Tan, D. X., Mayo, J. C., Sainz, R. M., Leon, J., & Czarnocki, Z. (2003). Melatonin as an antioxidant: biochemical mechanisms and pathophysiological implications in humans. Acta Biochim Pol., 50(4), 1129–46. doi: 0350041129

Zhang, H. M., & Zhang, Y. (2014). Melatonin: a well-documented antioxidant with conditional pro-oxidant actions. J Pineal Res., 57(2), 131–46. doi: 10.1111/jpi.12162

How to Cite

1.
Syusyuka VG. Level of biogenic amines in pregnant women with psycho-emotional disorders stipulated by anxiety. Pathologia [Internet]. 2017Dec.22 [cited 2024Nov.23];(3). Available from: http://pat.zsmu.edu.ua/article/view/118755

Issue

Section

Original research