Polymorphism of genes of hemostasis system, endothelial dysfunction and regulation of blood pressure in pregnant woman with preeclampsia and fetal growth retardation

Authors

  • T. O. Loskutova State Institution "Dnipropetrovsk Medical Academy of the Ministry of Health of Ukraine", Dnipro, Ukraine.,

DOI:

https://doi.org/10.14739/2310-1237.2018.1.127709

Keywords:

pre-eclampsia, pregnancy complications, fetal growth retardation, genetic polymorphism, risk factors

Abstract

Objective: To study the distribution and effect of blood clotting, endothelial dysfunction, and blood pressure regulator gene polymorphisms on the development of fetal growth retardation in women with preeclampsia (PE).

Materials and methods: a prospective cohort study that included 36 women with PE and FGR and 97 with PE without FGR was conducted. A determinations of genes polymorphisms in factor V Leiden 1691 G → A (FVL), prothrombin 20210 G → A, plasminogen activator inhibitor 1 type 675 5G / 4G (PAI-1), fibrinogen β 455 G → A, paraoxonasae 1 192 Q → R (PON-1), methylentetrahydrofolatereductase 677 C → T (MTHFR), angiotensinogen II 235 M → T (AGT II) were performed.

Results: it was found that the early onset of preeclampsia (up to 34 weeks), the duration of hypertension more than 4 weeks increase the relative risk of developing FGR in PE by 3.77 (95 % CI 1.85-7.66) and by 2.1 (95 % DI 1,2-3,6) times respectively. The severity of PE increases the risk of FGR almost by 2 times (RR = 1.98, 95 % CI 1.07-3.69). It was found that the frequency of abnormal polymorphisms was equally high between groups (80.5 % vs. 68.0 %). It was revealed that two or more abnormal polymorphisms were observed more often in pregnant women with PE and FGR (OR = 2.17, 95 % CI 1.26-3.72, p<0.01).

Conclusions: Pre-eclampsia is independently associated with the development of FGR. Our findings do not indicate that there are associations between studied maternal polymorphisms and an increased risk of intrauterine growth restriction in pregnant woman with preeclampsia

 

References

Vdovychenko, Yu. P., Tanko, O. P., Samoilova, M. V., & Sharashydze, K. Z. (2017) Zatrymka rostu ploda: kliniko-patohenetychni skladovi ta zasoby poperedzhennia. Adaptatsiia do mizhnarodnykh klinichnykh ustanov [Fetal growth retardation: clinical and pathogenetic components and preventive measures. Adaptation to international clinical settings]. Kyiv. [in Ukrainian].

Khodzhaeva, Z. S., Kholin, A. M., & Vikhlyaeva, E. M. (2013). Rannyaya i pozdnyaya pree'klampsiya: paradigmy patobiologii i klinicheskaya praktika [Early and late preeclampsia: pathobiology paradigms and clinical practice]. Akusherstvo i ginekologiya, 10, 4–11. [in Russian].

American College of Obstetricians and Gynecologists; Task Force on Hypertension in Pregnancy. (2013). Hypertension in Pregnancy: executive summary. Obstetrics & Gynecology, 122(5), 1122–1131. doi: 10.1097/01.AOG.0000437382.03963.88.

Gathiram, P., & Moodley, J. (2016). Pre-eclampsia: its pathogenesis and pathophysiolgy. Cardiovascular Journal of Africa, 27(2), 71–78. doi: 10.5830/CVJA-2016-009.

Simcox, L., Ormesher, L., Tower, C., & Greer, I. (2015). Thrombophilia and Pregnancy Complications. International Journal of Molecular Science, 16(12), 28418–28428. doi: 10.3390/ijms161226104.

Tranquilli, A. (2013). Introduction to ISSHP new classification of preeclampsia. Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health, 3(2), 58–9. doi: 10.1016/j.preghy.2013.04.006.

Downloads

How to Cite

1.
Loskutova TO. Polymorphism of genes of hemostasis system, endothelial dysfunction and regulation of blood pressure in pregnant woman with preeclampsia and fetal growth retardation. Pathologia [Internet]. 2018May3 [cited 2024Apr.26];(1). Available from: http://pat.zsmu.edu.ua/article/view/127709

Issue

No. 1 (2018)

Section

Original research

License

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
Лицензия Creative Commons
    1. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

  1. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (SeeThe Effect of Open Access).