Metabolic myocardial disorders in children with bronchial asthma

Authors

  • O. V. Herasymova National Pirogov Memorial Medical University, Vinnytsіa, Ukraine,
  • T. L. Protsiuk National Pirogov Memorial Medical University, Vinnytsіa, Ukraine,
  • L. O. Protsiuk National Pirogov Memorial Medical University, Vinnytsіa, Ukraine,
  • O. B. Dudarenko National Pirogov Memorial Medical University, Vinnytsіa, Ukraine,
  • O. V. Kuleshov National Pirogov Memorial Medical University, Vinnytsіa, Ukraine,

DOI:

https://doi.org/10.14739/2310-1237.2018.3.151707

Keywords:

bronсhial asthma, child, biomarkers, cardiovascular system

Abstract

Objective. To study specific features of potassium metabolism and myocardial damage markers in the children with bronchial asthma, depending on the level of BA control.
Materials and methods. Comprehensive examination was carried out in 189 children with persistent BA aged 6–17 years: group 1 consisted of 124 with uncontrolled course of the disease, group 2 – 30 patients with partially controlled BA and 35 patients with controlled BA. The comparison group consisted of 30 patients with controlled asthma without changes from the cardiovascular system.
The unified flame photometry method with fluid analyzer FFA-1 was used to determine the erythrocyte potassium level. Total creatine phosphokinase level was estimated by UV-test. Creatine phosphokinase-MB level was determined by M-subunit immunoinhibition. Total lactic dehydrogenase-1 level was calculated by modified colorimetric method using an assay kit for colorimetric determination of total LDH. Serum LDH1 level was estimated by UV-method with the kit for determination of isoenzyme LDH1 activity.
Results. In the children with UC BA serum K+ and erythrocyte K+ level was significantly lower compared to the children with PC BA, C BA, C BA with no changes in CVS and the control group. Total CPK and CPK-MB isoenzyme level in the children with UC BA, was significantly higher compared to those with PC BA, C BA, C BA without CVS changes and the control group. In the children with PC BA, total serum CPK level was also significantly higher compared to C BA (P = 0.007), C BA without CVS (P = 0.0002) changes and the control group (P = 0.001).
Conclusion. Thus, the study demonstrated significant decrease of potassium level in blood serum and erythrocytes, twofold increase of total creatine phosphokinase and lactic dehydrogenase-1 isoenzyme levels, threefold increase in creatine phosphokinase-MB isoenzyme level, and one and a half time increase of total lactic dehydrogenase in the children with uncontrolled course of bronchial asthma.


References

Schatz, M., & Rosenwasser, L. J. (2014) The allergic asthma phenotype. Allergy Clin Immunol Pract., 2(6), 645–8. doi: 10.1016/j.jaip.2014.09.004.

Farzan, S. (2013) The asthma phenotype in the obese: distinct or otherwise? J Allergy (Cairo), 2013. doi: 10.1155/2013/602908.

Rowan, S. C, Keane, M. P., Gaine S., & McLoughlin P. (2016) Hypoxic pulmonary hypertension in chronic lung diseases: novel vasoconstrictor pathways. Lancet Respir Med., 4(3), 225-36. doi: 10.1016/S2213-2600(15)00517-2.

Paulin, R., & Michelakis, E. D. (2014) The metabolic theory of pulmonary arterial hypertension. Circ Res., 115(1), 148–164. doi: 10.1161/CIRCRESAHA.115.301130.

Umalakshmi, V. & Bhargavi, K. (2015). Serum creatine kinase, lactate dehydrogenase and lipid profile in patients with asthma. Journal of Pharmacy and Biological Sciences, 10(3), 53–56. doi: 10.9790/3008-10335356.

Faruqi, R., Wilmot, C., Wright, A. H., & Morice, A. H. (2012) Serum LDH in chronic cough: a potential marker of airway inflammationcrj. The Clinical Respiratory Journal, 6(2), 81–87. doi: 10.1111/j.1752-699X.2011.00250.x.

Sahan, M., Yılmaz, M., Gokel, Y., Erden, E.S., & Karakus, A. (2013) Nebulized salbutamol for asthma: effects on serum potassium and phosphate levels at the 60 min. Rev. Port Pneumol, 19(5), 200–203. doi: 10.1016/j.rppneu.2012.12.003.

Ravikumar, P., Priyadarshini Bai, G., & Suryanarayana, H .V. (2013) Study of electro-lyte disturbances in acute asthma. Int J Biol Med Res., 4(3), 3479–3482.

Arunachalam, V., Venkatasubramanian, R., Heber, A., & Padmanabhan, R. (2016). Effect of salbutamol nebulization in serum potassium level in pediatric acute bronchial asthma. Іnternational journal of scientific research, 5(9), 198–204.

Mohammad, H. A., Abdulfttah, M. T., Abdulazez, A. O., Mahmoud, A. M., & Rasha, M. A. (2014). Study of electrolyte disturbances in patients with chronic stable asthma and with asthma attacks. Egyptian Journal of Chest Diseases and Tuberculosis,63(3), 529–534. doi: https://doi.org/10.1016/j.ejcdt.2014.03.010.

Lorensia, A., Ikawati, Z., Andayani, T., Maranatha, D., & Wahjudi, M. (2016) Comparison of Electrolyte Disturbance of Using Intravenous Aminophylline Versus Nebulization Salbutamol for Exacerbation Asthma in Surabaya, Indonesia. International Journal of Pharmaceutical and Clinical Research, 8(4), 221–228.

Andrzejowski, P., & Carroll, W. (2016) Salbutamol in paediatrics: pharmacology, prescribing and controversies. Arch Dis Child Educ Pract Ed., 101(4), 194–7. doi: 10.1136/archdischild-2014-307285.

Karmali, S. N., Sciusco, A., May, S. M., & Ackland, L. G. (2017) Heart rate variability in critical care medicine: a systematic review. Intensive Care Med Exp., 5(1), 33. doi: 10.1186/s40635-017-0146-1.

Shaikh, N., Reddy, Br., Gokani, R., & Patel, Bh. (2015). Prevalence of electrolyte disturbances in acute exacerbation of bronchial asthma. EJPMR., 2(5), 562–568.

Rachaiah, J., & Rachaiah, N. (2013) Unusual cause of hypokalemia and paralysis in an elderly patient with Bronchial Asthma. International Journal of Medical Science and Public Health., 2(4), 1114–1116. doi: 10.5455/ijmsph.2013.030720132.

Edgell, H., Moore, L.E.., Chung, C, Byers, B. W., & Stickland M. K. (2016). Short-term cardiovascular and autonomic effects of inhaled salbutamol. Respir Physiol Neurobiol., 231, 14–20. doi: 10.1016/j.resp.2016.05.014.

Lutfi, M. F. (2013) Electrolytes levels in asthmatic patients. Asian Journal of Biomedical and Pharmaceutical Sciences, 3(19), 1–4.

Oliveira, N. S., Silva, V. R., Castelo, J. S., Elias-Neto, J., Pereira, F.E., & Carvalho, W. B.. (2008) Serum level of cardiac troponin I in pediatric patients with sepsis or septic shock. Pediatr. Crit. Care. Med., 9(4), 414–417. doi: 10.1097/PCC.0b013e31817e2b33.

Healy, F., Hanna, B. D., & Zinman, R. (2010) Clinical practice. The impact of lung disease on the heart and cardiac disease on the lungs. Eur. J. Pediatr., 169(1), 1–6. doi: 10.1007/s00431-009-1027-8.

Umalakshmi, V., & Bhargavi, K. (2015) Serum creatine kinase, lactate dehydrogenase and lipid profile in patients with asthma. Journal of Pharmacy and Biological Sciences, 10(3), 53–56. doi: 10.9790/3008-10335356.

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1.
Herasymova OV, Protsiuk TL, Protsiuk LO, Dudarenko OB, Kuleshov OV. Metabolic myocardial disorders in children with bronchial asthma. Pathologia [Internet]. 2018Dec.19 [cited 2024Nov.23];(3). Available from: http://pat.zsmu.edu.ua/article/view/151707

Issue

No. 3 (2018)

Section

Original research

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