Clinic morphological features of Goodpasture’s syndrome manifested with respiratory disorders

Authors

  • Yu. M. Mostovoy National Pirogov Memorial Medical University, Vinnytsia, Ukraine,
  • A. V. Demchuk National Pirogov Memorial Medical University, Vinnytsia, Ukraine,
  • T. V. Konstantynovych National Pirogov Memorial Medical University, Vinnytsia, Ukraine,
  • N. O. Pentiuk National Pirogov Memorial Medical University, Vinnytsia, Ukraine,
  • L. V. Blazhevska Vinnytsia City Clinical Hospital #1, Ukraine,

DOI:

https://doi.org/10.14739/2310-1237.2018.3.151882

Keywords:

Goodpasture’s syndrome, respiratory failure, hemoptysis

Abstract

Goodpasture’s syndrome is one of rare pathological conditions. It stipulates problem of timely diagnostics and prescription of early pathogenic therapy for cessation of progressive autoimmune inflmmation and safe of patient’s life. Presented clinical case demonstrates diffilties of recognizing Goodpasture’s syndrome in case of its debut with dominating symptoms and
signs of bacterial affction of the lungs and severe respiratory failure.
Case presentation. We described case of Goodpasture’s syndrome in the middle-aged woman (54 years old) which began from symptoms of community-acquired pneumonia, hemoptysis and fiished tragically with developing severe respiratory and renal failures.
Conclusions. Management of community-acquired pneumonia patient, who has recurrent hemoptysis, minimal changes of the urinary system, who does not give adequate answer to the antibiotic treatment, must include additional investigation for revealing immunological systemic genesis of pulmonary tissue injury. It improves prognosis by virtue of early use adequate
pathogenic therapy.

References

Lahmer, T., & Heemann, U. (2012) Anti-glomerular basement membrane antibody disease: a rare autoimmune disorder affecting the kidney and the lung. Autoimmun Rev, 12(2), 169–173. doi: 10.1016/j.autrev.2012.04.002.

Kathuria, P., Sanghera, P., Stevenson F. T., & Sharma S. (2017) Goodpasture Syndrome. Medscape Reference: WebMD. Retrieved from https://emedicine.medscape.com/article/240556-overview.

Stanton, M. C., & Tange, J. D. (1958) Goodpasture’s syndrome (pulmonary haemorrhage associated with glomerulonephritis). Australas Ann Med, 7(2), 132–144.

Mostovoj, Y. M., & Demchuk, A. V. (2008) Sindrom Gudpaschera [Goodpasture Syndrome]. Zdorovia Ukrainy, 3/1, 56–57. Retrieved from http://health-ua.com/article/16926-sindrom-gudpaschera. [in Russian].

Pedchenko, V., Bondar, O., Fogo, A. B., Vanacore, R., Voziyan, P., Kitching, A. R., et al. (2010) Molecular architecture of the Goodpasture autoantigen in anti-GBM nephritis. N Engl J Med, 363(4), 343–354. doi: 10.1056/NEJMoa0910500.

Scollo, V., Zanoli, L., Russo, E., Distefano, G., & Rapisarda, F. A (2017) Case of Rare Diffuse Alveolar Hemorrhage and Review of Literature Clin Med Insights Case Rep, 10, 1179547617726077. doi: 10.1177/1179547617726077.

Yang, R., Cui, Z., Zhao, J., & Zhao, M. H. (2009) The role of HLA-DRB1 alleles on susceptibility of Chinese patients with anti-GBM disease. Clin Immunol, 133(2), 245–250. doi: 10.1016/j.clim.2009.07.005.

Kitagawa, W., Imai, H., Komatsuda, A., Maki, N., Wakui, H., Hiki, Y., & Sugiyama, S. (2008) The HLA-DRB1*1501 allele is prevalent among Japanese patients with anti-glomerular basement membrane antibody-mediated disease. Nephrol Dial Transplant, 23(10), 3126–3129. doi: 10.1093/ndt/gfn179.

Fisher, M., Pusey, C. D., Vaughan, R. W., & Rees, A. J. (1997) Susceptibility to anti-glomerular basement membrane disease is strongly associated with HLA-DRB1 genes. Kidney Int, 51(1), 222–229. doi: https://doi.org/10.1038/ki.1997.27.

Dammacco, F., Battaglia, S., Gesualdo, L., & Rakanelli, V. (2013) Goodpasture’s disease: a report of ten cases and a review of the literature. Autoimmune Rev, 12(11), 1101–1108. doi: 10.1016/j.autorev.2013.06.014.

Greco, A., Rizzo, M. I., De Virgiio, A., Gallo, A., Fusconi, M., Pagliuca, G., et al. (2015) Goodpasture’s syndrome: a clinical update. Autoimmune Rev, 14(3), 246–253. doi: 10.1016/j.autrev.2014.11.006.

Stojkovikj, J., Zejnel, S., Gerasimovska, B., Gerasimovska, V., Stojkovic, D., Trajkovski, M., et al. (2016) Goodpasture syndrome diagnosed one year and a half after the appearance of the first symptoms (case report). Open Access Maced J Med Sci, 4(4), 683–687. doi: 10.3889/oamjms.2016.127.

Huart, A., Josse, A. G., Chauveau, D., Korach, J. M., Heshmati, F., Bauvin, E., et al. (2016) Outcomes of patients with Goodpasture syndrome: a nationwide cohort-based study from the French Society of Hemapheresis. J. Autoimmun., 73, 24–29. doi: 10.1016/j.jaut.2016.05.015.

Van Daalen, E. E., Jennette, J. C., McAdoo, S. P., Pusey, C. D., Alba, M. A., Poulton, C. J., et al. (2018) Predicting outcome in patients with anti-GBM glomerulonephritis. Clin J Am Soc Nephrol, 13(1), 63–72. doi: 10.2215/CJN.04290417.

Iaremenko, O. B., Golovach, I. Yu., Stelmashchuk, V. P., Myasnyi, I. S., Mikhalchenko, E. M., Matijko, V. N., & Petrenko, L. V. (2018) Blagopriyatnyj iskhod gemorragicheskogo al'veolita, obuslovlennogo bolezn'yu antitel k bazal'noj membrane pochechnykh klubochkov, pri lechenii rituksimabom [A favorable outcome of hemorrhagic alveolitis caused by antibodies to glomerular basement membrane, in the treatment with rituximab]. Ukrainskyi pulmonolohichnyi zhyrnal, 2, 39–46. [in Russian]. doi: 10.31215/2306-4927-2018-100-2-39-46.

Downloads

How to Cite

1.
Mostovoy YM, Demchuk AV, Konstantynovych TV, Pentiuk NO, Blazhevska LV. Clinic morphological features of Goodpasture’s syndrome manifested with respiratory disorders. Pathologia [Internet]. 2018Dec.19 [cited 2024Apr.25];(3). Available from: http://pat.zsmu.edu.ua/article/view/151882

Issue

Section

Case Reports