Comparative morphometry of pial vessels in dyscirculatory-ischemic and diabetic encephalopathy
DOI:
https://doi.org/10.14739/2310-1237.2019.1.166331Keywords:
encephalopathy, brain ischemia, morphometry, pial vesselsAbstract
Aim – to determine the features of the morphometric parameters of the pial vessels of the brain in dyscirculatory-ischemic and diabetic encephalopathy.
Materials and methods. A histopathological and morphometric study of pial vessels of 30 sectional observations was carried out. The first group consisted of 10 deaths with dyscirculatory encephalopathy, the second group – 10 cases of diabetic encephalopathy with cognitive impairment in the anamnesis of type 2 diabetes mellitus. The third group (control) selected 10 cases without diabetes mellitus and without signs of cerebral vascular pathology.
Results. Compared with the control observations in diabetic and dyscirculatory-ischemic encephalopathy the thickness of the walls of vessels increases. In diabetic encephalopathy, the outer diameter increases, and the inner diameter decreases, the indices of the internal and external shape factors decrease, and the Vogenworth index and the Kernogan index increase significantly. In case of dyscirculatory-ischemic encephalopathy, the inner diameter decreases, the indices of the internal form factors decrease, the Vogenworth index and the Kernogan index increase. Thickening of the walls of microvessels compared with the norm is much more pronounced in diabetic encephalopathy than in dyscirculatory-ischemic one (by 43.55 % and 34.82 %, respectively), the difference is 8.73 %. Thickening of the vascular walls is accompanied by a decrease in the diameter of the microvessel lumen compared with the norm: by 1.87% for diabetic and by 8.74 % for dyscirculatory-ischemic. At the same time, the internal diameter of the vessels with dyscirculatory-ischemic encephalopathy decreases to a greater extent than with diabetic encephalopathy. The decrease in external and internal vascular wall shape factor is insignificant compared to the norm, and its degree does not depend on the nature of encephalopathy. An increase in the Wogenworth and Kernogan indices compared with the norm is characteristic for both encephalopathies, but more pronounced in diabetic one, which indicates a more severe impairment of blood circulation.
Conclusions: The data indicate that both in dyscirculatory-ischemic and diabetic encephalopathy a number of signs, that characterize significant pathological changes in the pial circulation, more pronounced in diabetic encephalopathy than in dyscirculatory-ischemic encephalopathy, regularly appear in the pial vessels of the brain,.
References
Kasatkina, S. G., & Kasatkin, S. N. (2011). Znachenie disfunkcii e'ndoteliya u bol'nykh sakharnym diabetom 2 tipa [The value of endothelial dysfunction in patients with type 2 diabetes mellitus]. Fundamental'nye issledovaniya, 7, 248–252. [in Russian].
Madonna, R., Pieragostino, D., Balistreri, C. R., Rossi, C., Geng, Y. J., Del Boccio, P., & De Caterina, R. (2018). Diabetic macroangiopathy: Pathogenetic insights and novel therapeutic approaches with focus on high glucose-mediated vascular damage. Vascular Pharmacology. doi: 10.1016/j.vph.2018.01.009
Madonna, R., Balistreri, C. R., Geng, Y. J., & De Caterina, R. (2017). Diabetic microangiopathy: Pathogenetic insights and novel therapeutic approaches. Vascular Pharmacology, 90, 1–7. doi: 10.1016/j.vph.2017.01.004
Tumansky, V. A., & Avramenko, Yu. N. (2013). Nekotorye aspekty morfogeneza diabeticheskoj e'ncefalopatii [Some aspects of morphogenesis of diabetic encephalopathy]. Zaporozhye medical journal, 4(79), 39–42. [in Russian]. doi: https://doi.org/10.14739/2310-1210.2013.4.16835
De Jong, R. N. (1950). The nervous system complications of diabetes mellitus, with special reference to cerebrovascular changes. The Journal of Nervous and Mental Disease, 3(111), 181–206.
Morozova, O. H. (2011). Metabolicheskie aspekty patogeneticheskoj terapii cerebral'nykh oslozhnenij sakharnogo diabeta [Pathogenic Therapy of Cerebral Complications of Diabetes Mellitus: Metabolic Aspects]. Lіky Ukrainy. Dіabet і sertse, 2(6), 4–10. [in Ukrainian].
Usmanova, D. D, & Khajibakiev, Kh. Kh. (2016). Osobennosti patogeneza razvitiya diabeticheskoj e'ncefalopatii (obzor) [Features of the pathogenesis of the development of diabetic encephalopathy (review)]. Vestnik Kazahskogo Nacional'nogo medicinskogo universiteta, 2, 366–370. [in Russian].
Lazarenko, V. V. (2000) Morfologicheskaya kharakteristika pial'nogo sosudistogo rusla nekotorykh funkcional'nykh zon kory bol'shogo mozga cheloveka (Avtoref. dis…kand. med. nauk). [Morphological characteristics of the pial vascular bed of some functional zones of the human cerebral cortex]. (Extended abstract of candidate’s thesis). Ufa. [in Russian].
Marilyn, J. C. (2009). The Cerebral Circulation. Colloquium Series on Integrated Systems Physiology: From Molecule to Function. 1(1), 1–59. doi: 10.4199/c00005ed1v01y200912isp002
Avtandilov, G. G. (2002). Osnovy kolichestvennoj patologicheskoj anatomii [Fundamentals of quantitative pathological anatomy]. Moscow: Medicinа. [in Russian].
Shkrobot, L. V. (2013). Osoblyvosti remodeliuvannia ta morfometrychna kharakterystyka sudyn pechinky i nyrok za umov reperfuzii tonkoi kyshky pislia usunennia yii eksperymentalnoi neprokhidnosti [Peculiarities of remodeling and morphometric characteristics of liver and kidney vessels under conditions of reperfusion of the small intestine after eliminating its experimental obstruction]. Tavricheskij mediko-biologicheskij vestnik. 16(1), 232–237. [in Ukrainian].
Shulhay, A. H., & Kitsak, Y. M. (2013). Morfometricheskaya ocenka osobennostej remodelirovaniya sosudistogo rusla terminal'nogo otdela podvzdoshnoj kishki pri mekhanicheskoj zheltukhe [Morphometric assessment of the features of remodeling bloodstream of the terminal segment of ileum at mechanical jaundice]. Zhurnal Grodnenskogo gosudarstvennogo meditsinskogo universiteta. 2(42), 39–42. [in Russian].
Shavrin, V. A., & Avramenko, Yu. N. (2017). Sravnitel'naya morfometriya cerebral'nykh mikrososudov pri ateroskleroticheskoj i diabeticheskoj e'ncefalopatiyakh [Comparative morphometry of cerebral microvessels in atherosclerotic and diabetic encephalopathies]. Morpholohiia, 11(1), 58–61. [in Russian].
Sarukhanov, T. M. (2014). Osobennosti diabeticheskoj angiopatii arterii golovnogo mozga (Avtoref. dis…kand. med. nauk). [Features of diabetic angiopathy of cerebral arteries. (Extended abstract of candidate’s thesis). Saint Petersburg. [in Russian].
Yanishevskij, S. N. (2014). Porazhenie golovnogo mozga pri sakharnom diabete 2 tipa (Avtoref. dis…kand. med. nauk). [Brain affection in type 2 diabetes mellitus. (Extended abstract of candidate’s thesis). Saint Petersburg. [in Russian].
Downloads
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (SeeThe Effect of Open Access).
