Morphological and biochemical indices of necro-inflammatory and fibrotic changes in the liver and their relationship between viral load in patients with CVH

Authors

  • A. O. Gavrilyuk

DOI:

https://doi.org/10.14739/2310-1237.2012.2.16718

Keywords:

chronic viral hepatitis, viral load, histological activity index, fibrosis stage

Abstract

The study involved 255 patients with chronic viral hepatitis. It was found that histological activity index and fibrosis stage do not depend on the genotype of HCV in patients with СHC and do not depend on HBeAg status in patients with СHВ. In HBV/HCV coinfected patients histological activity index was higher if HBV replication is dominated. Viral load in patients with СHC and СHВ  significantly weakly correlates with HAI and does not correlate with fibrosis stage. In 40% of patients with CHC and 23% of patients with CHB and low viral load HAI was > 9 points, and in 26% and 41% of patients respectively fibrosis stage was  > 2 points.

References

Бабак О.Я. Фиброз печени: современные представления о механизмах, способах диагностики и лечения / О.Я. Бабак, Е.В. Колесникова, Н.А. Кравченко // Сучасна гастроентерологія. – 2009. – №2 (46). – С. 5–17.

Філіппов Ю.О. Захворюваність основними хворобами органів травлення в України: аналітичний огляд офіційних даних Центру статистики МОЗ України / Ю.О. Філіппов, І.Ю. Скирда, Л.М. Петречук // Гастроентерологія. Міжвідомчий збірник. – Дніпропетровськ: Журфонд, 2007. – С. 3–15.

Bedossa P. The METAVIR cooperative study group. An algorithm for the grading of activity in chronic hepatitis C / P. Bedossa., T. Poynard // Hepatol. –1996. – №24. – Р. 289–293.

Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis / R.G. Knodell, K.G. Ishak, W.C. Black [et al.] // Hepatol. – 1981. – №1. – Р. 431–435.

Hepatology: A Clinical Textbook / [S. Mauss, T. Berg, J. Rockstroh et al.]. – [Snd Edition]. – Flying Publisher, 2010. – 509 р.

Histological grading and staging of chronic hepatitis / K. Ishak, A. Baptista., L. Bianchi. [et al.] // J. Hepatol. – 1995. – № 22. – Р. 696–699.

Is there a meaningful serum hepatitis B virus DNA cuttof level for therapeutic decisions in hepatitis B e antigen-negative chronic hepatitis B virus infection? / G.V. Papatheodoridis, E.K. Manesis, S. Manolakopoulos [et al.] // Hepatology. – 2008. – №48. – Р. 1451–1459.

Parola M. Hepatic wound repair / M. Parola, M. Pinzani // Fibrogenesis Tissue Repair. – 2009. – V. 25, №2 (1). – P. 4–11.

Predicting cirrhosis risk based on the level of circulating hepatitis B viral load / U.H. Iloeje, H.I. Yang, J. Su [et al.] // Gastroenterology. – 2006. – №130. – Р. 678–686.

Pinzani M. Fibrosis in chronic liver diseases: diagnosis and management / M. Pinzani, K. Rombouts, S. Colagrande // J. Hepatol. – 2005. – №42. – P. S 22–S 36.

Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level / C.J. Chen, H.I. Yang, J. Su [et al.] // JAMA. – 2006. – №295. – Р. 65–73.

Ticehurst J.R. Factors affecting serum concentrations of hepatitis C virus (HCV) RNA in HCV genotype 1-infected patients with chronic hepatitis / J.R. Ticehurst, F.M. Hamzeh, D.L. Thomas // J. Clin. Microbiol. – 2007. – №45 (8). – Р. 2426–2433.

Viral and host factors related with histopathologyc activity in patients with chronic hepatitis B and moderate or intermittently elevated alanine aminotransferase levels / E. Molina-Pérez, J. F. Castroagudín, A. Aguilera-Guirao [et al.] // Rev. Esp. Enferm. Dig. (Madrid). – 2010. – Vol. 102, №9. – Р. 519–525.

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Published

2013-08-28

How to Cite

1.
Gavrilyuk AO. Morphological and biochemical indices of necro-inflammatory and fibrotic changes in the liver and their relationship between viral load in patients with CVH. Pathologia [Internet]. 2013Aug.28 [cited 2024Apr.19];(2). Available from: http://pat.zsmu.edu.ua/article/view/16718

Issue

No. 2 (2012)

Section

Original research

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