Possibility of medicinal correction of disorders in metabolic cycle of neurotoxic transmitter glutamate in retina with neurotropic drugs during experimental glaucoma

Authors

  • V. M. Serdyuk

DOI:

https://doi.org/10.14739/2310-1237.2012.2.16756

Keywords:

glaucoma, glutamate, glutamine, glutamine synthetase, glutamate oxidase, glutaminase, memantine, citicoline

Abstract

Adult rabbits with experimental glaucoma were used in this study. We studied glutamate and glutamine levels and glutamine synthetase, glutamate oxidase and glutaminase activity in the eye tissue during glaucoma process. Results suggest increase of both glutamate level and glutaminase activity, as well as decrease of both glutamine level and glutamine synthetase and glutamate oxidase activity compared to normal ranges over all period of observation. This influence was significally prevented using neuroprotective drugs.

References

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Published

2013-08-29

How to Cite

1.
Serdyuk VM. Possibility of medicinal correction of disorders in metabolic cycle of neurotoxic transmitter glutamate in retina with neurotropic drugs during experimental glaucoma. Pathologia [Internet]. 2013Aug.29 [cited 2024Mar.29];(2). Available from: http://pat.zsmu.edu.ua/article/view/16756

Issue

Section

Original research