Рerisinusoidal-centrolobular liver fibrosis: features of morphogenegis and parameters of progression
DOI:
https://doi.org/10.14739/2310-1237.2012.3.17012Keywords:
perisinusoidal-centrolobular liver fibrosis, portal hypertensionAbstract
The research of morphogenesis of liver fibrosis in 589 patients with chronic viral hepatitis, alcoholic and non-alcoholic steatohepatitis has shown that perisinusoidal-centrоlobular liver fibrosis can develop at chronic liver diseases. This type of liver fibrosis is characterized by collagen deposition and fibrosis in perisinusoidal space of Disse in 3rd-2nd zones of liver acinus and around centrolobular veins at minimal or absent portal fibrosis. Severe perisinusoidal-central-lobular liver fibrosis is manifested by symptoms of portal hypertention before cirrhosis development.References
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