Рerisinusoidal-centrolobular liver fibrosis: features of morphogenegis and parameters of progression

Authors

  • V.A. Tumanskiy
  • Yu.A. Shebeko

DOI:

https://doi.org/10.14739/2310-1237.2012.3.17012

Keywords:

perisinusoidal-centrolobular liver fibrosis, portal hypertension

Abstract

The research of morphogenesis of liver fibrosis in 589 patients with chronic viral hepatitis, alcoholic and non-alcoholic steatohepatitis has shown that perisinusoidal-centrоlobular liver fibrosis can develop at chronic liver diseases. This type of liver fibrosis is characterized by collagen deposition and fibrosis in perisinusoidal space of Disse in 3rd-2nd zones of liver acinus and around centrolobular veins at minimal or absent portal fibrosis. Severe perisinusoidal-central-lobular liver fibrosis is manifested by symptoms of portal hypertention before cirrhosis development.

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Published

2013-09-12

How to Cite

1.
Tumanskiy V, Shebeko Y. Рerisinusoidal-centrolobular liver fibrosis: features of morphogenegis and parameters of progression. Pathologia [Internet]. 2013Sep.12 [cited 2024Mar.29];(3). Available from: http://pat.zsmu.edu.ua/article/view/17012

Issue

Section

Original research