Mitotic activity and nucleic acids content in the cells’ nuclei of epithelial colon tumors

Authors

  • A.N. Grabovoy National Cancer Institute, m. Kyiv, Ukraine,
  • S.A. Antoniuk National Cancer Institute, m. Kyiv, Ukraine,
  • E.A. Vorobey National Cancer Institute, m. Kyiv, Ukraine,

DOI:

https://doi.org/10.14739/2310-1237.2013.2.17361

Keywords:

colon epithelial tumor, Ki-67, nucleic acids

Abstract

Colon epithelial tumor (CEТ) malignancy grade determination cannot fully rely on the tumor cells’ nuclei DNA content and mitotic index as independent factors. The opposite vectors of the cellular spectrum can distinguish CEТ. The first one is characterized by the decrease in mitotic activity, and the second, contrariwise, by its increase, with increased cells’ DNA content. CEТ can be divided into those in which there is an increase in the average cells’ nuclei DNA content due to high proliferative activity (a large proportion of cells in which DNA synthesis occurs), and those in which this component is increased due to an increase of the cells proportion in the polyploid cells’ spectrum.

References

Автандилов Г.Г. Диагностическая медицинская плоидометрия / Автандилов Г.Г. – М.: Медицина, 2006. – 192 c.

Лупа Х. Основы гистохимии / Лупа Х.; пер. с нем. – М.: Мир, 1980. – 344 с.

Ташке К. Введение в количественную цито-гистологическую морфологию. / Ташке К.; пер. с рум. – М.: Из. Акад. Соц. Респ. Румынии, 1980. – 192 с.

Allegra C.J. Prognostic value of thymidylate synthase, Ki-67, and p53 in patients with Dukes’ B and C colon cancer: a National Cancer Institute-National Surgical Adjuvant Breast and Bowel Project collaborative study / Allegra C.J., Paik S., Colangelo L.H. // J Clin Oncol. – 2003. – V. 21 (2). – P. 241–250.

Compton C.C. Prognostic Factors in Colorectal Cancer / Compton C. C., Fielding L. P., Burgart L., [et al.] // Arch Pathol Lab Med. – 2000. – V. 124. – P. 979–994.

Davoli T. The Causes and Consequences of Polyploidy in Normal Development and Cancer / Davoli T., de Lange T. // Annu. Rev. Cell Dev. Biol. – 2011. – V. 27. – P. 585–610.

Franco L. Expression of p53 and Ki-67 as prognostic factors for survival of men with colorectal cancer / Franco Lumachi, Rocco Orlando, Filippo Marino, Giordano B. Chiara, Stefano M.M. Basso // Anticancer Research. – 2012. – V. 32 (9). – P. 3965–3967.

Fluge O. Expression of EZH3 and Ki-67 in colorectal cancer and associations with treatment response and prognosis / Fluge O., Gravdal K., Carlsen E., et al. // Br J Cancer. – 2009. – V. 101 (8). – P. 1282–1289.

Gerdes J. Ki-67 and other proliferation markers useful for immunohistological diagnostic and prognostic evaluations in humanmalignancies / Gerdes J. // Semin. Cancer Biol. – 1990. – V. 1 (3). – P. 199–206.

Guziсska-Ustymowicz K. Correlation between proliferation markers: PCNA, Ki-67, MCM-2 and antiapoptotic protein Bcl-2 in colorectal cancer / Guziсska-Ustymowicz K., Pryczynicz A., Kemona A., [et al.] // Anticancer Res. – 2009. – V. 29 (8). – P. 3049–3052.

Hadjihannas M.V. Aberrant Wnt/β-catenin signaling can induce chromosomal instability in colon cancer / Hadjihannas M.V., Brøckner M., Jerchow B., [et al.] // PNAS. – 2006. – V. 103 (28). – P. 10747–10752.

Hixon C. Flow cytometry in colon cancer: does flow cytometric cell cycle analysis help predict for short-term recurrence in patients with colorectal carcinoma? / Hixon C., Furlong J., Silbergleit A. // J Natl Med Assoc. – 1995. – V. 87 (11). – P. 803–806.

Holland A.J. Losing balance: the origin and impact of aneuploidy in cancer. / Holland A.J., Cleveland D.W. // EMBO. – 2012. – V. 13 (6). – P. 501–514.

Huh J.W. Expression of p16, p53, and Ki-67 in colorectal adenocarcinoma: a study of 356 surgically resected cases / Huh J.W., Lee J.H., Kim H.R. // Hepatogastroenterology. – 2010. – V. 57 (101). – P. 734–740.

Jiang S.M. Correlation of VEGF and Ki67 expression with sensitivity to neoadjuvant chemoradiation in rectal adenocarcinoma / Jiang S.M., Wang R.B., Yu J.M., [et al.] // Zhonghua Zhong Liu Za Zhi. – 2008. – V. 30 (8). – P. 602–605.

Søreide K. Microsatellite instability and DNA ploidy in colorectal cancer / Søreide K., Slewa A., Stokkeland P.J., van Diermen B., Janssen E.A., Søreide J.A., Baak J.P., Kørner H. // Cancer. – 2009. – V. 115 (2). – P. 271–282.

Kubota Y. Ki-67-determined growth fraction versus standard staging and grading parameters in colorectal carcinoma. A multivariate analysis / Kubota Y., Petras R.E., Easley K.A., [et al.] // Cancer. – 1992. – V. 70 (11). – P. 2602–2609.

Lin M.X. Expression and significance of Bmi-1 and Ki67 in colorectal carcinoma tissues / Lin M.X., Wen Z.F., Feng Z.Y. // Ai Zheng. – 2008. – V. 27 (12). – P. 1321–1326.

Maksimovic S. Immunohistochemical markers (PCNA, KI-67 and P53) in patients with colon cancer / Maksimovic S., Jakovljevic B // Annals of Oncology. – 2007. – V. 18 (9). – P. 168–172.

Menezes H.L. Analysis of the immunohistochemical expressions of p53, bcl-2 and Ki-67 in colorectal adenocarcinoma and their correlations with the prognostic factors / Menezes H.L., Juc M.J., Gomes E.G., [et al.] // Arq. Gastroenterol. – 2010. – V. 47 (2). – P. 141–147.

Palmqvist R. Low tumour cell proliferation at the invasive mar- gin is associated with a poor prognosis in Duke’s stage B colorectal cancer / Palmqvist R, Sellberg P, Sellberg Е, Tavelin B, Rutegеrd J, Stenling R. // Br J Cancer. – 1999. – V. 79. – P. 577–581.

Park S.U. Effects of Chromosomal Polyploidy on Survival of Colon Cancer Cells / Park S.U., Choi E.S., Jang Y.S., [et al.] // Korean J Gastroenterol. – 2011. – V. 57 (3). – P. 150–157.

Salminen E. Increased proliferation activity measured by immunoreactive Ki67 is associated with survival improvement in rectal/recto sigmoid cancer / Salminen E., Palmu S., Vahlberg T., [et al.] // World J Gastroenterol. – 2005. – V. 11 (21). – P. 3245–3249.

Ueda Y. Biological predictors of survival in stage II colorectal cancer / Yoshitake Ueda, Kazuhiro Yasuda, [et al.] // Molecular and Clinical Oncology – 2013. – V. 1 (4) – P. 643–648.

Valera V.A. Prognostic groups in colorectal carcinoma patients based on tumor cell proliferation and classification and regression tree (CART) survival analysis / Valera V.A., Walter B.A., Yokoyama N., [et al.] // Ann Surg Oncol. – 2007. – V. 14 (1). – P. 34–40.

Weber J.C. Is a proliferation index of cancer cells a reliable prognostic factor after hepatectomy in patients with colorectal liver metastases? / Weber J.C., Nakano H., Bachellier P., [et al.] // Am J Surg. – 2001. – V. 182 (1). – P. 81–88.

Zlobec I. Combined histomorphologic and immunohistochemical phenotype to predict the presence of vascular invasion in colon cancer / Zlobec I., Höller S, [et al.] // Dis Colon Rectum. – 2009. – V. 52 (6). – P. 1114–1121.

How to Cite

1.
Grabovoy A, Antoniuk S, Vorobey E. Mitotic activity and nucleic acids content in the cells’ nuclei of epithelial colon tumors. Pathologia [Internet]. 2013Sep.30 [cited 2024Nov.23];(2). Available from: http://pat.zsmu.edu.ua/article/view/17361

Issue

Section

Original research