The content of apoptosis mediators in children with anemia of inflammation acquired on the background of acute bacterial diseases of respiratory organs
DOI:
https://doi.org/10.14739/2310-1237.2019.2.177112Keywords:
infants, respiratory tract diseases, caspase-7, caspase-9, anemia of inflammationAbstract
Aim. Determine the activity of apoptosis processes in young children with anemia of inflammation acquired on the background of acute bacterial diseases of respiratory organs.
Material and methods. The content of caspase-7 and caspase-9 was identified in blood serum of 87 kids by the method of immunoenzyme assay. Main group included 57 kids with acute bacterial diseases of the respiratory tract (38 patients had acute bacterial bronchitis, 19 - pneumonia). The main group was divided into two subgroups. The first subgroup included 27 children with developed anemia of inflammation acquired on the background of acute bacterial disease of the respiratory tract. Second subgroup - 30 children with acute bacterial diseases of the respiratory tract without anemia. Experimental group - 10 children with iron deficiency anemia without symptoms of inflammatory diseases of the respiratory system. The control group was represented by 20 conditionally healthy children.
Results. The presence of pneumonia in children was accompanied by the highest numbers of caspase-9 (14.8 ± 1.8 ng/ml), which was almost 3 times higher than the control group (5.82 ± 0.58 ng/ml). The levels of the studied enzyme were 1.6 times lower in patients with bacterial bronchitis (8.34 ± 0.90 ng/ml), which was significantly higher (P < 0.05) than in the control group. The content of caspase-7 in the experimental group and the 2nd subgroup of the main group did not differ from the control group (P > 0.05) (0.38 ± 0.03 ng/ml and 0.32 ± 0.02 ng/ml), and children of the 1st subgroup (0.27 ± 0.02 ng/ml) showed its significant decrease.
Conclusions. Anemia of inflammation in children with acute bacterial diseases of respiratory organs is accompanied by the activation of apoptosis, which, obviously, is inefficient due to the nature of the active necrotic processes acquired on the background of acute inflammation.
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