Comprehensive approach to the problem of the effect of residual monomer on the immune-metabolic profile of patients with orthopedic treatment of non-removable temporary constructions
DOI:
https://doi.org/10.14739/2310-1237.2019.2.177197Keywords:
crowns, residual methylmethacrylate, immunometabolic profile, secretory immunoglobulin A, glutathione, catalase, superoxide dismutase, urease, lysozymeAbstract
The purpose of this work was to study the clinical effectiveness of the application of an advanced method of manufacturing temporary structures and its combination with the applications of hyaluronic acid and the internal administration of quercetin.
Materials and methods. The subject of the study was the oral fluid, which was collected before preparation (stage I), 7 days after the establishment of the temporary structure (stage II), 14 days after the installation of permanent non-removable structure (stage III). In the oral fluid, the level of sIgA content and indicators of the state of oxidative homeostasis: reduced glutathione (RG), superoxide dismutase (SOD), catalase, urease and lysozyme were studied. The level of sIgA content was determined using the technique of immunoassay analysis using Vector-Best reagents. RG, SOD, catalase, urease and lysozyme have been investigated in biochemical spontaneous reactions, in accordance with the recommendations of existing methods. All patients were divided into 3 groups: I – control group, which used the standard methodology for the manufacture of temporary structures; ІІ – the main, for patients whose temporary structures were made according to an improved technique with evacuation; for the patients of the III (main) group temporary structures with the advanced technique and the parallel application of hyaluronic acid and quercetin were made.
Results. Significant increase in the level of sIgA content was registered at the second stage – 7 days after the establishment of a temporary orthopedic construction (P < 0.05). At the same time, the reliable difference between the values of the indicators of I and II, I and III groups at the third stage was recorded – P ˂ 0.001. Significant differences in the level of activity of SOD in oral fluid were achieved between patients of groups I and III after the establishment of NOCs (respectively (1561.0 ± 36.0) с.u./min and (1442.0 ± 28.0) с.u./min, P < 0.05). At ІІ stage, the difference between the groups of comparison I and II by the level of catalase content was reliable at the level P < 0.05 – (6.54 ± 0.26) с.u./min and (5.3 ± 0.41) с.u./min, respectively, while the difference between I and III groups was reliable at P ˂ 0.01, the catalase index at the ІІ stage was(4.86 ± 0.48) с.u./min in the third group. At the third stage, in the It group, there was a further increase in the catalase to (8.64 ± 0.29) с.u./min, while the second and third group of patients had a significantly (P ˂ 0.001) better result – (5.33 ± 0.33) с.u./min and (4.48 ± 0.36) с.u./min, respectively. At the third stage of orthopedic treatment in the I group the lysozyme index is reduced to (39 ± 5) с.u./min, whereas in patients of group ІІ there is an increase in the result to (75 ± 6) с.u./min, and in ІІІ group it is completely stabilized, equaling (96 ± 4) c.u./min, P ˂ 0.01.
Conclusions. Thus, by combining the use of the advanced prosthetic technique and the preparations of hyaluronic acid and quercetin, we have proved the effectiveness of this method and on the basis of the experimental and clinical results, we can safely assert that it is a complex approach to the problem of the effect of residual monomer on the immune-metabolic profile of patients with orthopedic treatment of non-removable temporary constructions to be the most effective.
References
Bida, V. I. (2018) Kliniko-tekhnologicheskie osobennosti vosstanovleniya defektov zubnykh ryadov mostovidnymi zubnymi protezami (chast' 2) [Clinical and technological features of the restoration of defects of the dentition bridges dentures (part 2)]. Stomatolog, 9, 50−57. [in Russian].
Holik, V. P., Yanishen, I. V., & Yarova, A. V. (2014) Otsіnka vplyvu na іmunolohіchnyi profіl patsіentіv na etapakh ortopedychnoho lіkuvannia neznіmnymy zubnymy protezamy [Evaluation of the influence on the immunological profile of patients in the stages of orthopedic treatment with non-removable dentures]. Ukrainskyi medychnyі almanakh, 17(2), 22–25. [in Ukrainian].
Holik, V. P., Yarova, A. V., & Pohorila, A. V. (2014) Otsіnka vplyvu ortopedychnoho lіkuvannia neznіmnymy protezamy z zastosuvanniam tymchasovykh koronok na іmunometabolіchnyi profіl patsіentіv [Estimation of the influence of orthopedic treatment with non-removable dentures with the use of temporary crowns on the immune metabolic profile of patients]. Stomatolohinfo, 3, 34–37. [in Ukrainian].
Zhmurov, V. O., Mal'tsev, V. I., Yefimtseva, T. K., & Kovtun, L. I. (2014) Obrobka danykh ta analіz rezultatіv klіnіchnykh vyprobuvan lіkarskykh zasobіv [Data processing and analysis of the results of clinical trials of drugs]. Ukrainskyі medychnyі chasopys, 6, 34–38. [in Ukrainian].
Zgonnik, O. S. (2014) Sravnitel'naya ocenka fiziko-mekhanicheskikh svojstv nekotorykh stomatolohicheskikh plastmass [Comparative evaluation of the physico-mechanical properties of some dental plastics]. Ukrainskyi stomatolohichnyі almanakh, 1, 4–6. [in Russian].
Kyslova, O. V., Sapatyі, A. L., & Kupnovytska, I. G. (2017) Korektsіia endotelіalnoi dysfunktsii, vyklykanoi vplivom γ-opromіnennia, za dopomohoiu rozchinnoho ta lіposomalnoho kvertsetynu [Correction of endothelial dysfunction caused by γ-irradiation by soluble and liposomal quercetin]. Fiziolohichnyі zhurnal, 53(3), 78–81. [in Ukrainian].
Lapach, S. N., Gubenko, A. V., & Babich, P. N. (2014) Statisticheskie metody v mediko-biologicheskikh issledovaniyakh s vnedreniem EXCEL [Statistical methods in biomedical research with the introduction EXCEL]. Moscow: Morion. [in Russian].
Lishhuk, V. A. (2014) Informatizaciya klinicheskoj mediciny [Informatization in clinical medicine]. Klіnicheskaya іnformatika і telemedicina, 1(1), 17−27. [in Russian].
Yarova, S. P., Butuk, D. V., Vakhіd Khadzhi Safar (2014) Rezul'taty primeneniya enterosgelya pri lechenii vospalitel'nykh zabolevanij parodonta [The results of using Enterosgel in the treatment of inflammatory periodontal diseases]. Sovremennaya stomatologіya, 3, 54–55. [in Russian].
Yanishen, I. V., Golik, V. P., Yarova, A. V., Pogorila, A. V. (2014) Otsinka vplyvu ortopedychnoho likuvannia neznimnymy zubnymy protezamy z zastosuvanniam tymchasovykh koronok na imunolohichnii profil patsientiv [Evaluation of the influence of orthopedic treatment with non-removable dentures with the use of temporary crowns on the immune-metabolic profile of patients]. Stomatologinfo, 11, 34–37. [in Ukrainian].
Yanishen, I. V., Golik, V. P., Yarova, A. V., & Yaryna, I. M. (2015) Orthopedychne likuvannia neznimnymy zubnymy prothezamy z zastosuvanniam tymchasovykh koronok ta otsinka vplyvu na imunolohichnii profil patsientiv [Orthopedic treatment of non-removable dentures with the use of temporary crowns and an assessment of the impact on the immune-metabolic profile of patients]. Voprosy e'ksperimental'noj i klinicheskoj stomatologii Proceedings of the Scientific and Practical Conference with International the participation, (P. 11–16). Kharkiv. [in Ukrainian].
Yanishen, I. V., Holik, V. P., & Yarova, A. V. (2015) Kliniko-orientovani tekhnologii yakosti orthopedychnogo likuvannia neznimnymy konstruktsiiamy: tymchasovi koronky [Clinical-oriented technologies of quality of orthopedic treatment with non-removable structures: temporary crowns]. Kharkiv: Styl-izdat. [in Ukrainian].
Yarina, I. M. (2018) Doslidzhennia vplyvu neznimnykh orthopedichnykh konstruktsii na imunolohichnyi profil patsientiv [Investigation of the effect of non-removable orthopedic structures on the patient’s immune-met-abolic profile]. Visnyk problem biolohii i medytsyny, 4(2), 368–372. [in Ukrainian]. doi: 10.29254/2077-4214-2018-4-2-147-368-372
Altintas, S. H., Yondem, I., Tak, O., & Usumez, A. (2008) Temperature rise during polymerization of three different provisional materials. Clin. Oral. Investig, 12(3), 283–286. [in Ukrainian]. doi: 10.1007/s00784-007-0163-7
Yanishen, I. V., Krychka, N. V., Diudina, I. L., Biriukova, M. M., & Kuznetsov, R. V. (2017) Employment of functional tests in multivariable modeling of plastic dentures in patients with complete absence of teeth. Medical Education,12(2), 51. 1494–1498.
Yanishen, I., Diudina, I., Krychka, N., Diieva, T., Kuznetsov, R. (2019) Experimental justification of a method-of-choice to protect the receptor apparatus of the teeth, supporting a non-removable design denture. Georgian Medical News, 286, 36–39.
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