DOI: https://doi.org/10.14739/2310-1237.2020.1.203859

Сучасний погляд на роль Toll-подібних рецепторів у функціонуванні імунної системи та імунопатогенезі хронічного гепатиту С (огляд літератури)

L. M. Syzova, T. I. Koval, V. I. Ilchenko, I. M. Zviaholska, О. M. Iziumska

Анотація


 

Незважаючи на великі досягнення у вивченні імунопатогенезу хронічного гепатиту С, залишається багато невирішених питань щодо діагностики, прогнозування перебігу та ефективності лікування. У контексті вивчення цієї інфекції викликають інтерес рецептори вродженої імунної системи – Toll-подібних рецепторів.

Мета роботи – проаналізувати відомості сучасної фахової літератури щодо ролі окремих Toll-подібні рецептори в імунопатогенезі хронічного гепатиту С.

Матеріали та методи. Методами оглядового, системного та контент-аналізу опрацювали доступні наукові джерела, що присвячені вивченню Toll-подібних рецепторів. Наведені дані світової фахової літератури та проаналізовані результати сучасних досліджень.

Висновки. Вроджена імунна система відіграє визначальну роль у первинному захисті організму від патогенів, розпізнавання яких залежить від родини Toll-подібних рецепторів, а генетичний аналіз – перспективний метод превентивної та персоналізованої медицини. Перевага генетичних маркерів полягає в тому, що вони незалежно від віку та інших факторів містять інформацію про схильність до мультифакторіальних хвороб, що можна використати під час створення «генетичного паспорта» людини. Уявлення щодо впливу поліморфізму Asp299Gly гена Toll-подібного рецептора 4 і Gln11Leu гена Toll-подібного рецептора 7 на імунопатогенез хронічного гепатиту С неоднозначні та потребують продовження вивчення. Це дасть змогу оптимізувати лікувально-діагностичну тактику при цьому захворюванні на основі комплексного оцінювання особливостей імунного реагування, що зумовлені наявністю названих поліморфізмів.


Ключові слова


Toll-подібні рецептори; поліморфізм; хронічний гепатит С

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