Heart pathomorphological changes in the long-term alcohol consumption

Authors

DOI:

https://doi.org/10.14739/2310-1237.2020.2.212734

Keywords:

alcoholism, heart, pathology

Abstract

 

Alcohol is one of the leading causes of death worldwide, annually taking 3 million lives. Alcohol abuse to a greater degree negatively affects the functioning of the cardiovascular system.

Aim. Studying the severity of pathomorphological changes in the heart of deceased patients with alcoholism.

Materials and methods. The heart sections of 35 deceased alcoholic patients (38–60 years old) were taken for histo-morphometric analysis. As a comparison group, the material of deceased patients (n = 15), suffering from ischemic heart disease (IHD) and hypertension disease (HD) was studied.

Results. In conditions of alcoholism in 100 % of cases myocardium showed marked microcirculatory disorders, increased vascular permeability. In all cases sclerotic changes similar in topography to the comparison group were noted, however, sclerosis of large arterioles was 1.9 times less pronounced than in IHD group. In the myocardium of alcoholics, edema, atrophy of cardiomyocytes bundles and areas of fatty stroma are common. In 20 % of cases, there were mosaic necrosis of individual cardiomyocytes and small focal necrosis of small groups of cells, fibrinoid necrosis of small branches of coronary arteries. Compared with IHD group the number of fatty degenerated cardiomyocytes increased by 1.23 times, fuchsinophilic cardiomyocytes – by 1.38 times with simultaneous reducing severity of sclerotic changes in vessels by 1.9 times. Sclerotic changes in stroma are significantly higher in relation to IHD and HD groups (by 1.88 and 6.94 times, respectively).

Conclusions. The morphogenesis of heart damage during alcoholism consists of combination of dystrophic, necrotic, atrophic and sclerotic changes – morphological substrate of alcoholic cardiomyopathy. These signs, based on quantitative analysis, are important criteria necessary for the thanatogenetic analysis in cases of death on the background of alcoholism.

References

Witkiewitz, K., Litten, R. Z., & Leggio, L. (2019). Advances in the science and treatment of alcohol use disorder. Science advances, 5(9), eaax4043. https://doi.org/10.1126/sciadv.aax4043

Pan, X. Q., Zhang, Y. H., Liu, Y. Y., & Tong, W. J. (2010). Interaction between the C(-344)T polymorphism of CYP11B2 and alcohol consumption on the risk of essential hypertension in a Chinese Mongolian population. European journal of epidemiology, 25(11), 813-821. https://doi.org/10.1007/s10654-010-9504-y

Piano, M. R. (2017). Alcohol's Effects on the Cardiovascular System. Alcohol Research-Current Reviews, 38(2), 219-242.

Maisch, B. (2016). Alcoholic cardiomyopathy : The result of dosage and individual predisposition. Alkoholische Kardiomyopathie : Eine Folge der Dosis und der individuellen Prädisposition. Herz, 41(6), 484-493. https://doi.org/10.1007/s00059-016-4469-6

Tolstrup, J. S., Wium-Andersen, M. K., Ørsted, D. D., & Nordestgaard, B. G. (2016). Alcohol consumption and risk of atrial fibrillation: Observational and genetic estimates of association. European journal of preventive cardiology, 23(14), 1514-1523. https://doi.org/10.1177/2047487316641804

Gillis, A. M. (2020). A Sober Reality? Alcohol, Abstinence, and Atrial Fibrillation. The New England journal of medicine, 382(1), 83-84. https://doi.org/10.1056/NEJMe1914981

Larsson, S. C., Wallin, A., Wolk, A., & Markus, H. S. (2016). Differing association of alcohol consumption with different stroke types: a systematic review and meta-analysis. BMC medicine, 14(1), 178. https://doi.org/10.1186/s12916-016-0721-4

Paloczi, J., Matyas, C., Cinar, R., Varga, Z. V., Hasko, G., Schindler, T. H., Kunos, G., & Pacher, P. (2019). Alcohol Binge-Induced Cardiovascular Dysfunction Involves Endocannabinoid-CB1-R Signaling. JACC. Basic to translational science, 4(5), 625-637. https://doi.org/10.1016/j.jacbts.2019.05.007

Rehm, J., & Roerecke, M. (2017). Cardiovascular effects of alcohol consumption. Trends in cardiovascular medicine, 27(8), 534-538. https://doi.org/10.1016/j.tcm.2017.06.002

Ajani, U. A., Gaziano, J. M., Lotufo, P. A., Liu, S., Hennekens, C. H., Buring, J. E., & Manson, J. E. (2000). Alcohol consumption and risk of coronary heart disease by diabetes status. Circulation, 102(5), 500-505. https://doi.org/10.1161/01.cir.102.5.500

Steiner, J. L., & Lang, C. H. (2017). Etiology of alcoholic cardiomyopathy: Mitochondria, oxidative stress and apoptosis. The international journal of biochemistry & cell biology, 89, 125-135. https://doi.org/10.1016/j.biocel.2017.06.009

Fernández-Solà J. (2020). The Effects of Ethanol on the Heart: Alcoholic Cardiomyopathy. Nutrients, 12(2), 572. https://doi.org/10.3390/nu12020572

Li, X., Nie, Y., Lian, H., & Hu, S. (2018). Histopathologic features of alcoholic cardiomyopathy compared with idiopathic dilated cardiomyopathy. Medicine, 97(39), e12259. https://doi.org/10.1097/MD.0000000000012259

Husain, K., Ansari, R. A., & Ferder, L. (2014). Alcohol-induced hypertension: Mechanism and prevention. World journal of cardiology, 6(5), 245-252. https://doi.org/10.4330/wjc.v6.i5.245

Matsumoto, C., Miedema, M. D., Ofman, P., Gaziano, J. M., & Sesso, H. D. (2014). An expanding knowledge of the mechanisms and effects of alcohol consumption on cardiovascular disease. Journal of cardiopulmonary rehabilitation and prevention, 34(3), 159-171. https://doi.org/10.1097/HCR.0000000000000042

Fernández-Solà, J., & Planavila Porta, A. (2016). New Treatment Strategies for Alcohol-Induced Heart Damage. International journal of molecular sciences, 17(10), 1651. https://doi.org/10.3390/ijms17101651

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1.
Tertyshnyi SI, Shuliatnikova TV, Zubko MD. Heart pathomorphological changes in the long-term alcohol consumption. Pathologia [Internet]. 2020Sep.28 [cited 2024Mar.28];(2). Available from: http://pat.zsmu.edu.ua/article/view/212734

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Original research