Evaluation of functional state of muscular system in children with diabetes mellitus
DOI:
https://doi.org/10.14739/2310-1237.2020.2.212770Keywords:
type 1 diabetes, children, muscular strength, diabetic myopathyAbstract
Aim. To evaluate the functional condition of skeletal muscles in children with type 1 diabetes (T1D), according to the duration of disease based on studying static and dynamic physical endurance.
Materials and methods. 76 children with T1D from 11 to 17 years old were examined. The first group included 20 kids with the duration of diabetes less than 1 year. The second group – 27 patients with T1D from 1 to 5 years. The third group – 29 kids with T1D over 5 years. The group of control included 16 conventionally healthy children. Static muscular endurance with evaluation of total static muscular endurance (TSME) and dynamic muscular endurance with evaluation of wrist strength index (WSI) were evaluated. The index of muscle quality (IMQ) was evaluated too.
Results. The greater duration of T1D was accompanied by the redistribution of percentage ratio of body components. The TSME was decreasing alomg with increase of T1D duration. Reverse correlation between glycated hemoglobin and TSME (r = -0.50; P < 0.05) was shown. The dynamic endurance revealed the progressing decrease of WSI before and after the physical exertion in children with T1D in comparison with the control group. The revealed peculiarities of functional condition of muscles were connected with TSME (r = +0.43, P < 0.05) and IMQ (r = +0.52, P < 0.05).
Conclusions. Functional condition of skeletal muscles in children with T1D is characterized by decrease of static and dynamic muscular endurance. The first signs of changes are observed over the first year of disease and progress as the duration of a disease increases and leads to decrease of mucle mass and diabetic myopathy developing. The major factor contributing the worsening of functional condition of muscles is insufficient glycemic control.
References
Maratova, K., Soucek, O., Matyskova, Ja., Hlavka, Zd., Petruzelkova, L., Obermannova, B., Pruhova, St., Kolouskova, S., Sumnik, Zd. (2018). Muscle functions and bone strength are impaired in adolescents with type 1 diabetes. Bone, 106, 22-27. http://doi.org/10.1016/j.bone.2017.10.005
Dydyshko, Yu. V., & Shepel'kevich, A. P. (2015). Vozmozhnosti otsenki sostoyaniya myshechnogo komponenta v norme i pri sakharnom diabete 1-go tipa [Opportunities for assessing the state of the muscle component in normal conditions and in type 1 diabetes mellitus]. Meditsinskaya panorama, (5), 45-50. [in Russian].
Monaco, C. M. F., Perry, C. G. R., & Hawke, T. J. (2017). Diabetic Myopathy: current molecular understanding of this novel neuromuscular disorder. Current Opinion in Neurology, 30(5), 545-552. https://doi.org/10.1097/wco.0000000000000479
Hirata, Y., Nomura, K., Senga, Y., Okada, Y., Kobayashi, K., Okamoto, S., Minokoshi, Y., Imamura, M., Takeda, S., Hosooka, T., & Ogawa, W. (2019). Hyperglycemia induces skeletal muscle atrophy via a WWP1/KLF15 axis. Jci Insight, 4(4), Article e124952. https://doi.org/10.1172/jci.insight.124952
Nakamura, P. M., Mielke, G. I., Horta, B. L., Assungdo, M. C., Goncalves, H., Menezes, A. M. B., Barros, F. C., Ekelund, U., Brage, S., Wehrmeister, F. C., Oliveira, I. O., & Hallal, P. C. (2017). Physical Activity Throughout Adolescence and Hba1c in Early Adulthood: Birth Cohort Study. Journal of Physical Activity & Health, 14(5), 375-381. https://doi.org/10.1123/jpah.2016-0245
Peters, A. M., Snelling, H. L. R., Glass, D. M., & Bird, N. J. (2011). Estimation of lean body mass in children. British Journal of Anaesthesia, 106(5), 719-723. https://doi.org/10.1093/bja/aer057
Zanardo, M., Doniselli, F. M., Esseridou, A., Tritella, S., Mattiuz, C., Menicagli, L., Di Leo, G., & Sardanelli, F. (2018). Abdominal CT: a radiologist-driven adjustment of the dose of iodinated contrast agent approaches a calculation per lean body weight. European radiology experimental, 2(1), 41. https://doi.org/10.1186/s41747-018-0074-1
Kim, H. T., Kim, H. J., Ahn, H. Y., & Hong, Y. H. (2016). An analysis of age-related loss of skeletal muscle mass and its significance on osteoarthritis in a Korean population. Korean Journal of Internal Medicine, 31(3), 585-593. https://doi.org/10.3904/kjim.2015.156
Kupusinac, A., Stokic, E., & Doroslovacki, R. (2014). Predicting body fat percentage based on gender, age and BMI by using artificial neural networks. Computer Methods and Programs in Biomedicine, 113(2), 610-619. https://doi.org/10.1016/j.cmpb.2013.10.013
Proskurov, E. M. (2012). Funktsional'noe sostoyanie serdechno sosudistoi sistemy u mal'chikov 10-11 let posle staticheskikh uprazhnenii s sobstvennoi massoi tela [The functional state of cardiovascular system for boys 10 - 11 years old after static exercises with deadweight of body]. Pedagogika, psihologia ta mediko-biologicni problemi fizicnogo vihovanna i sportu, (11), 79-84. [in Russian]. https://doi.org/10.6084/m9.figshare.97367.v1
Vasil'eva, A. A., & Konovalova, T. G. (2019). Otsenka silovoi vynoslivosti myshts spiny i pressa kak sposob kontrolya profilaktiki skolioza studentov 3 kursa 2-oi funktsional'noi gruppy [Evaluation of strength endurance of the muscles of the back and the press as a way to control the prevention of scoliosis of 3rd year students of the 2nd functional group]. Studencheskii, (22). [in Russian]. https://sibac.info/journal/student/42/122149.
Truhacheva, N. V. (2017). Meditsinskaya statistika: uchebnoye posobiye [Medical statistics: training manual]. Rostov na Donu: Feniks. [in Russian].
Abdulkadirova, F. R., Ametov, A. S., Doskina, E. V., & Pokrovskaya, R. A. (2014). Rol' lipotoksichnosti v patogeneze sakharnogo diabeta 2 tipa i ozhirenii [The role of lipotoxicity in the pathogenesis of type 2 diabetes and obesity]. Ozhirenie i metabolizm, 11(2), 8-12. [in Russian]. https://doi.org/10.14341/omet201428-12
Carnagarin, R., Dharmarajan, A. M., & Dass, C. R. (2015). Molecular aspects of glucose homeostasis in skeletal muscle - A focus on the molecular mechanisms of insulin resistance. Molecular and Cellular Endocrinology, 417(C), 52-62. https://doi.org/10.1016/j.mce.2015.09.004
Umegaki, H. (2015). Sarcopenia and diabetes: Hyperglycemia is a risk factor for age-associated muscle mass and functional reduction. Journal of Diabetes Investigation, 6(6), 623-624. https://doi.org/10.1111/jdi.12365
Downloads
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (SeeThe Effect of Open Access).