Revival of the concept and development of donation after human circulatory death in the era of organ transplantation

Authors

  • V. O. Tumanskyi Zaporizhzhia State Medical University, Ukraine,
  • S. I. Vorotyntsev Zaporizhzhia State Medical University, Ukraine,
  • L. M. Tumanska Zaporizhzhia State Medical University, Ukraine,

DOI:

https://doi.org/10.14739/2310-1237.2020.2.212811

Keywords:

donors, circulatory death, organ transplantation

Abstract

 

Since the beginning of the twentieth century, in parallel with the standards of the whole brain death and the brain stem death of a donor used in transplantology, the concept of donation after human circulatory death has received a practical revival.

Aim: analysis of the revival of the concept of circulatory death of a person and donor protocols after its ascertaining.

The review analyzes retrospective data on the development of the concept of circulatory death of a person, widely used in modern transplantology. It has been established that the main criteria for human circulatory death, adopted in all countries with active organ transplantation programs, are the patient’s loss of blood circulation and breathing. The features of donor protocols after controlled and uncontrolled circulatory death, donation after euthanasia, modern technologies of explantation and preservation of donor organs, as well as moral and ethical problems associated with controlled donation after circulatory death are defined.

Conclusion. The widespread donation after the patient's circulatory death led to significant success in transplantation of kidneys, lungs, liver, pancreas and heart.

 

References

Machado C. (2007). The First Organ Transplant from a Brain-Dead Donor. In: Brain Death. Springer, New York, NY. https://doi.org/10.1007/978-0-387-38977-6_2

Beecher, H. K. (1968). A definition of irreversible coma: Report of the ad hoc committee of the Harvard medical school to examine the definition of brain death. JAMA: The Journal of the American Medical Association, 205(6), 337-340. doi:10.1001/jama.1968.03140320031009

Guidelines for the determination of death. Report of the medical consultants on the diagnosis of death to the President's Commission for the Study of Ethical Problems in Medicine and Biomedical and Behavioral Research. (1981). JAMA, 246(19), 2184-2186.

Tumanskyi, V. O., & Tumanska, L. M. (2020). Kliniko-patomorfologicheskie parametry smerti mozga: ot istokov kontseptsii do ee primeneniya pri transplantatsii organov [Clinical and pathomorphological parameters of brain death: from the origins of the concept to its use in organ transplantation]. Pathologia, 17(1), 102-113. https://doi.org/10.14739/2310-1237.2020.1.203850

World Health Organization. (‎1991)‎. International Digest of Health Legislation. World Health Organization - Vol. 42(3), 393-394.

World Health Organization. (‎1998)‎. Health legislation at the dawn of the 21st century. World Health Organization - Vol. 49(‎Special issue)‎. https://apps.who.int/iris/handle/10665/63933

Gautier, S. V., & Khomyakov, S. M. (2017). Donorstvo i transplantatsiya organov v Rossiiskoi Federatsii v 2016 godu IX soobshchenie registra Rossiiskogo transplantologicheskogo obshchestva [Organ donation and transplantation in the Russian Federation in 2016 9th report of the National Registry]. Russian Journal of Transplantology and Artificial Organs, 19(2), P. 6-26. [in Russian]. https://doi.org/10.15825/1995-1191-2017-2-6-26

U.S. Department of Health & Human Services (2018, January 8). Deceased organ donors in US exceeded 10 thousand for first time in 2017. Organ Procurement and Transplantation Network. https://optn.transplant.hrsa.gov/news/deceased-organ-donors-in-us-exceeded-10-thousand-for-first-time-in-2017/

Manyalich, M., Nelson, H., & Delmonico, F. L. (2018). The need and opportunity for donation after circulatory death worldwide. Current opinion in organ transplantation, 23(1), 136-141. https://doi.org/10.1097/MOT.0000000000000486

Greer, D. M., Wang, H. H., Robinson, J. D., Varelas, P. N., Henderson, G. V., & Wijdicks, E. F. (2016). Variability of Brain Death Policies in the United States. JAMA neurology, 73(2), 213-218. https://doi.org/10.1001/jamaneurol.2015.3943

John Paul, Pope. (2000, August 29). Address to the 18th International Congress of the Transplantation Society. http://w2.vatican.va/content/john-paul-ii/en/speeches/2000/jul-sep/documents/hf_jp-ii_spe_20000829_transplants.html

WHO, Transplantation Society (TTS), & Organizatión Nacional de Transplantes (ONT) (2011). Third WHO Global Consultation on Organ Donation and Transplantation: striving to achieve self-sufficiency, March 23-25, 2010, Madrid, Spain. Transplantation, 91 Suppl 11, S27-S28. https://doi.org/10.1097/TP.0b013e3182190b29

Thuong, M., Ruiz, A., Evrard, P., Kuiper, M., Boffa, C., Akhtar, M. Z., Neuberger, J., & Ploeg, R. (2016). New classification of donation after circulatory death donors definitions and terminology. Transplant international : official journal of the European Society for Organ Transplantation, 29(7), 749-759. https://doi.org/10.1111/tri.12776

Lewis, A., Adams, N., Varelas, P., Greer, D., & Caplan, A. (2016). Organ support after death by neurologic criteria: Results of a survey of US neurologists. Neurology, 87(8), 827-834. https://doi.org/10.1212/WNL.0000000000003008

Bernat J. L. (2018). Conceptual Issues in DCDD Donor Death Determination. The Hastings Center report, 48 Suppl 4, S26-S28. https://doi.org/10.1002/hast.948

Kootstra, G., Daemen, J. H., & Oomen, A. P. (1995). Categories of non-heart-beating donors. Transplantation proceedings, 27(5), 2893-2894.

Detry, O., Le Dinh, H., Noterdaeme, T., De Roover, A., Honoré, P., Squifflet, J. P., & Meurisse, M. (2012). Categories of donation after cardiocirculatory death. Transplantation proceedings, 44(5), 1189-1195. https://doi.org/10.1016/j.transproceed.2012.05.001

Gardiner, D., & McGee, A. (2017). Death, permanence and current practice in donation after circulatory death. QJM : An International Journal of Medicine, 110(4), 199-201. https://doi.org/10.1093/qjmed/hcw184

Hornby, K., Hornby, L., & Shemie, S. D. (2010). A systematic review of autoresuscitation after cardiac arrest. Critical care medicine, 38(5), 1246-1253. https://doi.org/10.1097/CCM.0b013e3181d8caaa

Ortega-Deballon, I., Hornby, L., & Shemie, S. D. (2015). Protocols for uncontrolled donation after circulatory death: a systematic review of international guidelines, practices and transplant outcomes. Critical care (London, England), 19(1), 268. https://doi.org/10.1186/s13054-015-0985-7

Sandroni, C., D'Arrigo, S., & Nolan, J. P. (2018). Prognostication after cardiac arrest. Critical care (London, England), 22(1), 150. https://doi.org/10.1186/s13054-018-2060-7

Nolan, J. P., Soar, J., Cariou, A., Cronberg, T., Moulaert, V. R., Deakin, C. D., Bottiger, B. W., Friberg, H., Sunde, K., & Sandroni, C. (2015). European Resuscitation Council and European Society of Intensive Care Medicine Guidelines for Post-resuscitation Care 2015: Section 5 of the European Resuscitation Council Guidelines for Resuscitation 2015. Resuscitation, 95, 202-222. https://doi.org/10.1016/j.resuscitation.2015.07.018

Sandoval, E., Fernández-Cisneros, A., & Boada, M. (2020). DCD lungs: is it all the same?. Annals of cardiothoracic surgery, 9(1), 54-55. https://doi.org/10.21037/acs.2019.11.07

Blackstock, M. J., & Ray, D. C. (2014). Organ donation after circulatory death: an update. European journal of emergency medicine : official journal of the European Society for Emergency Medicine, 21(5), 324-329. https://doi.org/10.1097/MEJ.0000000000000082

Guzik-Makaruk, E. M., Olesiuk-Okomska, M., Matuszkiewicz-Rowińska, J., & Małyszko, J. (2019). Selected Legal Aspects of Donation After Circulatory Death in Poland. Annals of transplantation, 24, 93-99. https://doi.org/10.12659/AOT.912567

Slipchenko, S., Shyshka, O., Buletsa, S., Sinegubov, O., & Hrynko, R. (2018). Sostoyanie mezhdunarodnogo pravovogo regulirovaniya posmertnogo donorstva: na puti k unifikatsii (obzor) [The state of international legal regulation of cadaveric donation: on the path to unification (review)]. Georgian Medical News, (10), 175-179.

Eurotransplant International Foundation. Eurotransplant region. Eurotransplant. https://www.eurotransplant.org/about-eurotransplant/region/

Antommaria, A. H. M., Fallat, M. E., Katz, A. L., Mercurio, M. R., Moon, M. R., Okun, A. L., Webb, S. A., & Weise, K. L. (2013). Policy Statement Ethical Controversies in Organ Donation After Circulatory Death. Pediatrics, 131(5), 1021-1026. https://doi.org/10.1542/peds.2013-0672

Reznik O. N., Skvortcov A. E., & Popova O. V. (2018). Ethical issues of organ donation after cardiac death. Russian Journal of Transplantology and Artificial Organs, 20(3), 116-125. [in Russian]. https://doi.org/10.15825/1995-1191-2018-3-116-125

Nair-Collins, M., Green, S. R., & Sutin, A. R. (2015). Abandoning the dead donor rule? A national survey of public views on death and organ donation. Journal of medical ethics, 41(4), 297-302. https://doi.org/10.1136/medethics-2014-102229

Bernat J. L. (2010). How the distinction between "irreversible" and "permanent" illuminates circulatory-respiratory death determination. The Journal of medicine and philosophy, 35(3), 242-255. https://doi.org/10.1093/jmp/jhq018

Shemie, S. D., Hornby, L., Baker, A., Teitelbaum, J., Torrance, S., Young, K., Capron, A. M., Bernat, J. L., Noel, L., & The International Guidelines for Determination of Death phase 1 participants, in collaboration with the World Health Organization (2014). International guideline development for the determination of death. Intensive care medicine, 40(6), 788-797. https://doi.org/10.1007/s00134-014-3242-7

McGee, A., & Gardiner, D. (2018). Donation After the Circulatory Determination of Death: Some Responses to Recent Criticisms. The Journal of medicine and philosophy, 43(2), 211-240. https://doi.org/10.1093/jmp/jhx037

Smith, M., Dominguez-Gil, B., Greer, D. M., Manara, A. R., & Souter, M. J. (2019). Organ donation after circulatory death: current status and future potential. Intensive care medicine, 45(3), 310-321. https://doi.org/10.1007/s00134-019-05533-0

Hessheimer, J. A., & Fondevila, C. (2019). Normothermic Regional Perfusion in Solid Organ Transplantation. In Advances in Extracorporeal Membrane Oxygenation - Volume 3. IntechOpen. https://doi.org/10.5772/intechopen.84771

Turgeon, A. F., Lauzier, F., Simard, J. F., Scales, D. C., Burns, K. E. A., Moore, L., … Fergusson, D. A. (2011). Mortality associated with withdrawal of life-sustaining therapy for patients with severe traumatic brain injury: A Canadian multicentre cohort study. CMAJ, 183(14), 1581-1588. https://doi.org/10.1503/cmaj.101786

Tibballs, J., & Bhatia, N. (2015). Transplantation of the heart after circulatory death of the donor: time for a change in law?. The Medical journal of Australia, 203(6), 268-70.e1. https://doi.org/10.5694/mja15.00295

Tchana-Sato, V., Ledoux, D., Detry, O., Hans, G., Ancion, A., D'Orio, V., Massion, P. B., Amabili, P., Bruls, S., Lavigne, J. P., Monard, J., Delbouille, M. H., Sakalihasan, N., & Defraigne, J. O. (2019). Successful clinical transplantation of hearts donated after circulatory death using normothermic regional perfusion. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 38(6), 593-598. https://doi.org/10.1016/j.healun.2019.02.015

Bollen, J., de Jongh, W., Hagenaars, J., van Dijk, G., Ten Hoopen, R., Ysebaert, D., Ijzermans, J., van Heurn, E., & van Mook, W. (2016). Organ Donation After Euthanasia: A Dutch Practical Manual. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 16(7), 1967-1972. https://doi.org/10.1111/ajt.13746

Bollen, J., Shaw, D., de Wert, G., Ten Hoopen, R., Ysebaert, D., van Heurn, E., & van Mook, W. (2019). Euthanasia through living organ donation: Ethical, legal, and medical challenges. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 38(2), 111-113. https://doi.org/10.1016/j.healun.2018.07.014

Evrard, P., & Belgian Working Group on DCD National Protocol (2014). Belgian modified classification of Maastricht for donors after circulatory death. Transplantation proceedings, 46(9), 3138-3142. https://doi.org/10.1016/j.transproceed.2014.09.169

Neyrinck, A., Van Raemdonck, D., & Monbaliu, D. (2013). Donation after circulatory death: current status. Current opinion in anaesthesiology, 26(3), 382-390. https://doi.org/10.1097/ACO.0b013e328360dc87

Summers, D. M., & Pettigrew, G. J. (2020). Kidney transplantation following uncontrolled donation after circulatory death. Current opinion in organ transplantation, 25(2), 144-150. https://doi.org/10.1097/MOT.0000000000000742

Dhital, K. K., Chew, H. C., & Macdonald, P. S. (2017). Donation after circulatory death heart transplantation. Current opinion in organ transplantation, 22(3), 189-197. https://doi.org/10.1097/MOT.0000000000000419

Sandoval, E., Fernández-Cisneros, A., & Boada, M. (2020). DCD lungs: is it all the same?. Annals of cardiothoracic surgery, 9(1), 54-55. https://doi.org/10.21037/acs.2019.11.07

Ceulemans, L. J., Inci, I., & Van Raemdonck, D. (2019). Lung donation after circulatory death. Current opinion in organ transplantation, 24(3), 288-296. https://doi.org/10.1097/MOT.0000000000000627

Ruiz, P., Gastaca, M., Bustamante, F. J., Ventoso, A., Palomares, I., Prieto, M., Fernández, J. R., Salvador, P., Pijoan, J. I., & Valdivieso, A. (2019). Favorable Outcomes After Liver Transplantation With Normothermic Regional Perfusion From Donors After Circulatory Death: A Single-center Experience. Transplantation, 103(5), 938-943. https://doi.org/10.1097/TP.0000000000002391

Miñambres, E., Rubio, J. J., Coll, E., & Domínguez-Gil, B. (2018). Donation after circulatory death and its expansion in Spain. Current opinion in organ transplantation, 23(1), 120-129. https://doi.org/10.1097/MOT.0000000000000480

Oderberg D. S. (2019). Death, unity, and the brain. Theoretical medicine and bioethics, 40(5), 359-379. https://doi.org/10.1007/s11017-019-09479-8

Rakhra, S. S., Opdam, H. I., Gladkis, L., Arcia, B., Fink, M. A., Kanellis, J., Macdonald, P. S., Snell, G. I., & Pilcher, D. V. (2017). Untapped potential in Australian hospitals for organ donation after circulatory death. The Medical journal of Australia, 207(7), 294-301. https://doi.org/10.5694/mja16.01405

How to Cite

1.
Tumanskyi VO, Vorotyntsev SI, Tumanska LM. Revival of the concept and development of donation after human circulatory death in the era of organ transplantation. Pathologia [Internet]. 2020Sep.28 [cited 2024Nov.2];(2). Available from: http://pat.zsmu.edu.ua/article/view/212811

Issue

Section

Review