Cytokine profile of patients with the measles infection of varying severity
DOI:
https://doi.org/10.14739/2310-1237.2021.1.215491Keywords:
measles, cytokines, interferonAbstract
Aim: to determine the nature of the cytokine response in patients with measles infection of varying severity, both with and without complications.
Materials and methods. 65 patients who were treated in the Kharkiv regional infectious hospital from 2017 to 2019 were included in the study. All patients were divided into 4 groups depending on the severity of the disease and the presence of complications.
All patients included in the study on the day of admission to the hospital and on the 10th day of hospital stay were examined for serum concentrations of pro- and anti-inflammatory cytokines as well as interferons alpha and gamma, which was carried out by solid-phase enzyme immunoassay using kits manufactured by “Vector-best” company (RF) according to the manufacturer’s instructions. Statistical processing of the obtained data was carried out using the IBM SPSS Statistics 22.0 software package.
Results. The study of the levels of pro- and anti-inflammatory cytokines in dynamics showed a decrease in their levels on the 10th day of hospital stay in patients who did not have complications, and their increase in patients whose illness was accompanied by the development of pneumonia. Levels of INFα and INFγ in dynamics increased in all groups of patients. Significant changes in relation to the control group in the ratio of pro- and anti-inflammatory cytokines in the dynamics were observed only in patients with a dissociative type of cytokine response. In patients of this group on the 1st and 10th days of hospital stay the ratio index of IL-6/IL-10 was shifted towards a significant predominance of proinflammatory cytokines.
Conclusions. The study demonstrates the presence of three possible types of cytokine response in patients with measles infection of varying severity: normoreactive, dissociative and hyporeactive. Each type was typical to a specific group of patients and influenced the clinical course of the disease and the development of complications, which is associated with the dynamics of increasing levels of pro- and anti-inflammatory cytokines and increasing levels of INFα and INFγ. The dynamics of increase in levels of these factors in severe disease is lower than in moderate disease. Taking into account the obtained data it can be assumed that in process of anti-infectious immunity formation in response to measles infection the prevalence of the Th-1 immune response over the Th-2 response becomes important.
References
Ministry of Health of Ukraine. (n.d.). Tsentr hromadskoho zdorovia MOZ Ukrainy [Public Health Center of the Ministry of Health of Ukraine]. https://phc.org.ua/search/content?keys=%D0%BA%D1%96%D1%80
Laksono, B. M., de Vries, R. D., McQuaid, S., Duprex, W. P., & de Swart, R. L. (2016). Measles Virus Host Invasion and Pathogenesis. Viruses, 8(8), 210. https://doi.org/10.3390/v8080210
Naim H. Y. (2015). Measles virus. Human vaccines & immunotherapeutics, 11(1), 21-26. https://doi.org/10.4161/hv.34298
Agafonov, A. P., Ignat'ev, G. M., P'yankov, S. A., & Losev, M. V. (2002). Kor'. Sovremennye predstavleniya o vozbuditele, klinika, diagnostika, profilaktika [Measles. Modern ideas about the pathogen, clinic, diagnostics, prevention]. Novosibirsk. [in Russian].
Griffin, D. E. (2016). The Immune Response in Measles: Virus Control, Clearance and Protective Immunity. Viruses, 8(10), 282. https://doi.org/10.3390/v8100282
Griffin, D. E. (2010). Measles virus-induced suppression of immune responses. Immunological reviews, 236, 176-189. https://doi.org/10.1111/j.1600-065X.2010.00925.x
Solovieva, S. A. (2015). Protivovirusnyi immunitet [Antiviral immunity]. Biulleten fiziologii i patologii dykhaniia, (56), 113-118. [in Russian].
Laksono, B. M., de Vries, R. D., Verburgh, R. J., Visser, E. G., de Jong, A., Fraaij, P., Ruijs, W., Nieuwenhuijse, D. F., van den Ham, H. J., Koopmans, M., van Zelm, M. C., Osterhaus, A., & de Swart, R. L. (2018). Studies into the mechanism of measles-associated immune suppression during a measles outbreak in the Netherlands. Nature communications, 9(1), 4944. https://doi.org/10.1038/s41467-018-07515-0
Markelova, E., Kostyushko, A., & Krasnikov, V. (2008). Patogeneticheskaya rol' narushenii v sisteme tsitokinov pri infektsionno-vospalitel'nykh zabolevaniyakh [Pathogenetic role of the in cytokine system changes at infectious and inflammatory diseases]. Pacific Medical Journal, (3), 24-29. [in Russian].
Fantetti, K. N., Gray, E. L., Ganesan, P., Kulkarni, A., & O'Donnell, L. A. (2016). Interferon gamma protects neonatal neural stem/progenitor cells during measles virus infection of the brain. Journal of neuroinflammation, 13(1), 107. https://doi.org/10.1186/s12974-016-0571-1
Downloads
Published
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (SeeThe Effect of Open Access).