The effect of hyperbilirubinemia on pain intesity in patients with pancreatobiliaric cancer during perioperative period

Authors

DOI:

https://doi.org/10.14739/2310-1237.2020.3.221820

Keywords:

hyperbilirubinhaemia, pain syndrome, pancreas, pancreatic cancer, resection

Abstract

 

The aim was to assess the effect of hyperbilirubinemia on the severity of pain syndrome in patients with pancreatobiliary cancer during perioperative period.

Materials and methods. The results of surgical treatment of 218 patients with pancreatobiliary cancer complicated by the development of mechanical jaundice syndrome, who underwent pancreatoduodenal resection, were analyzed. The severity of pain was assessed on a visual-analog scale, as well as subscales of questionnaires EORTC QLQ-C30 and SF-36.

Results. At the time of admission to the hospital the initial level of total bilirubin was 274.3 ± 5.9 μmol/L, direct - 211.2 ± 2.2 μmol/L, indirect – 63.4 ± 2.6 μmol/L. The intensity of pain syndrome on admission was 4.9 ± 0.4 points. In the early, late and late postoperative period the intensity of pain decreased, respectively, from 6.4 ± 0.3  to 2.8 ± 0.4 points.

Conclusions. A strong positive correlation between the intensity of pain syndrome and the level of cholemia was determined (r = 0.74).

 

References

Fillingim, R. B., Loeser, J. D., Baron, R., & Edwards, R. R. (2016). Assessment of Chronic Pain: Domains, Methods, and Mechanisms. The journal of pain, 17(9 Suppl), T10-T20. https://doi.org/10.1016/j.jpain.2015.08.010

Koulouris, A. I., Banim, P., & Hart, A. R. (2017). Pain in Patients with Pancreatic Cancer: Prevalence, Mechanisms, Management and Future Developments. Digestive diseases and sciences, 62(4), 861-870. https://doi.org/10.1007/s10620-017-4488-z

Ukrainian cancer registry statistics. (2020). Cancer in Ukraine, 2018-2019. Occupation, death, demonstration of oncological service. Bulletin of National Cancer Registry of Ukraine (Vol. 21, pp. 30-31). http://www.ncru.inf.ua/publications/BULL_21/PDF_E/30-31-podg.pdf

Hwang, I. C., Park, Y., Lee, Y. J., & Ahn, H. Y. (2017). Simple Biomarkers During the Last Month of Life of Terminal Cancer Patients: A Sequential Study. Journal of pain and symptom management, 53(1), e1-e3. https://doi.org/10.1016/j.jpainsymman.2016.08.021

Hashimoto, M., Aogaki, K., Numata, C., Moriwaki, K., Matsuda, Y., Ishii, R., Tanaka, I., & Okamoto, Y. (2020). Factors influencing the prescribed dose of opioid analgesics in cancer patients. Journal of opioid management, 16(4), 247-252. https://doi.org/10.5055/jom.2020.0578

How to Cite

1.
Muraviov PT, Zaporozhchenko BS, Borodaiev IY, Kirpichnikova KP, Shevchenko VH, Volkov VB, Makrem H. The effect of hyperbilirubinemia on pain intesity in patients with pancreatobiliaric cancer during perioperative period. Pathologia [Internet]. 2020Dec.29 [cited 2024Mar.29];(3). Available from: http://pat.zsmu.edu.ua/article/view/221820

Issue

Section

Original research