Prognostic value of serum S100B concentration in patients with acute spontaneous supratentorial intracerebral hemorrhage
DOI:
https://doi.org/10.14739/2310-1237.2021.1.228850Keywords:
cerebral hemorrhage, S100B protein, prognosisAbstract
Aim of the work – to evaluate the informativeness of serum protein S100B levels in detection of short-term prognosis in patients with acute period of spontaneous supratentorial intracerebral hemorrhage (SSICH) on the background of concervative therapy.
Materials and methods. Prospective cohort study of 90 patients with acute SSICH on the background of conservative therapy was done. Level of neurological deficit was evaluated using Full Outline of Unresponsiveness Scale, Glasgow Coma Scale and National Institute of Health Stroke Scale. Computed tomography was done to detect the intracerebral hemorrhage volume (ICHV), secondary intraventricular hemorrhage volume (SIVHV) and total volume of intracranial hemorrhage (TVICH). Laboratory blood samples were taken within 24 hours of hospitalization. Levels of S100B protein in serum were measured using immunoassay analysis. Unfavorable variants of course (early neurological deterioration (END) during 48 hours from hospitalization) and disease acute period outcome of ICH (modified Rankin score 4–6 on the 21st day of the disease) were considered as endpoints. Statistical processing of the obtained results included correlation analysis, logistic regression analysis and ROC-analysis.
Results. Neurological deterioration during 48 hours after hospitalization was detected in 18 (20.0 %) patients, unfavorable SSICH acute period outcome was revealed in 49 (54.4 %) patients. It was detected that serum S100B protein correlates with ICHV (R = 0.34, P ˂ 0.01), SIVHV (R = 0.39, P ˂ 0.01) and TVICH (R = 0.45, P ˂ 0.01). Thus, the patients with unfavorable SSICH acute period course and outcome are characterized with the higher S100B protein levels (P ˂ 0.0001). High sensitive multipredicive logistic regression model that integrates prognostic value of serum of S100B protein concentration with informativeness of clinical, neurological parameters (National Institute of Health Stroke Scale score, SIVHV) was elaborated. It helps to detect the individual risk of unfavorable acute SSICH period outcome on the ground of conservative therapy with the accuracy 90.0 % (AUC ± SE (95 % CІ) = 0.95 ± 0.02 (0.89–0.99), P ˂ 0.0001).
Conclusions. Serum S100B protein levels in patients with SSICH on the 1st day after hospitalization is the informative additional parameter in verification of short-term prognosis on the background of conservative therapy.
References
Pinho, J., Costa, A. S., Araújo, J. M., Amorim, J. M., & Ferreira, C. (2019). Intracerebral hemorrhage outcome: A comprehensive update. Journal of the neurological sciences, 398, 54-66. https://doi.org/10.1016/j.jns.2019.01.013
An, S. J., Kim, T. J., & Yoon, B. W. (2017). Epidemiology, Risk Factors, and Clinical Features of Intracerebral Hemorrhage: An Update. Journal of stroke, 19(1), 3-10. https://doi.org/10.5853/jos.2016.00864
Akpinar, E., Gürbüz, M. S., & Berkman, M. Z. (2019). Factors Affecting Prognosis in Patients With Spontaneous Supratentorial Intracerebral Hemorrhage Under Medical and Surgical Treatment. The Journal of craniofacial surgery, 30(7), e667-e671. https://doi.org/10.1097/SCS.0000000000005733
Zhou, S., Bao, J., Wang, Y., & Pan, S. (2016). S100β as a biomarker for differential diagnosis of intracerebral hemorrhage and ischemic stroke. Neurological research, 38(4), 327-332. https://doi.org/10.1080/01616412.2016.1152675
Yuan, X. S., & Bian, X. X. (2008). S100B protein and its clinical effect on craniocerebral injury. Chinese journal of traumatology = Zhonghua chuang shang za zhi, 11(1), 54-57. https://doi.org/10.1016/s1008-1275(08)60012-7
Glushakova, O. Y., Glushakov, A. V., Miller, E. R., Valadka, A. B., & Hayes, R. L. (2016). Biomarkers for acute diagnosis and management of stroke in neurointensive care units. Brain circulation, 2(1), 28-47. https://doi.org/10.4103/2394-8108.178546
Wang, K. K., Yang, Z., Zhu, T., Shi, Y., Rubenstein, R., Tyndall, J. A., & Manley, G. T. (2018). An update on diagnostic and prognostic biomarkers for traumatic brain injury. Expert review of molecular diagnostics, 18(2), 165-180. https://doi.org/10.1080/14737159.2018.1428089
Dadas, A., Washington, J., Diaz-Arrastia, R., & Janigro, D. (2018). Biomarkers in traumatic brain injury (TBI): a review. Neuropsychiatric disease and treatment, 14, 2989-3000. https://doi.org/10.2147/NDT.S125620
Zhou, S., Bao, J., Wang, Y., & Pan, S. (2016). S100β as a biomarker for differential diagnosis of intracerebral hemorrhage and ischemic stroke. Neurological research, 38(4), 327-332. https://doi.org/10.1080/01616412.2016.1152675
Kuznietsov A. A. (2018). Comparative analysis of predictive significance of neuroimaging parameters in patients with spontaneous supratentorial intracerebral hemorrhage. Zaporozhye Medical Journal, 20(4), 543-547. https://doi.org/10.14739/2310-1210.2018.4.137097
Ferrete-Araujo, A. M., Rodríguez-Rodríguez, A., Egea-Guerrero, J. J., Vilches-Arenas, Á., Godoy, D. A., & Murillo-Cabezas, F. (2019). Brain Injury Biomarker Behavior in Spontaneous Intracerebral Hemorrhage. World neurosurgery, 132, e496-e505. https://doi.org/10.1016/j.wneu.2019.08.090
Zhou, S., Bao, J., Wang, Y., & Pan, S. (2016). S100β as a biomarker for differential diagnosis of intracerebral hemorrhage and ischemic stroke. Neurological research, 38(4), 327-332. https://doi.org/10.1080/01616412.2016.1152675
Alatas, Ö. D., Gürger, M., Ateşçelik, M., Yildiz, M., Demir, C. F., Ekingen, E., Kalayci, M., Ilhan, N., & Acar, E. (2015). Neuron-Specific Enolase, S100 Calcium-Binding Protein B, and Heat Shock Protein 70 Levels in Patients With Intracranial Hemorrhage. Medicine, 94(45), e2007. https://doi.org/10.1097/MD.0000000000002007
Dilek, A., Alacam, H., Ulger, F., Bedir, A., Ulus, A., Murat, N., Okuyucu, A., & Polat, F. (2013). Comparison of predictive powers of S100B and cell-free plasma DNA values in intensive care unit patients with intracranial hemorrhage. Journal of critical care, 28(5), 883.e1-883.e8837. https://doi.org/10.1016/j.jcrc.2013.03.005
Eldawoody, H., Mattar, M., Mesbah, A., Zaher, A., & Elsherif, M. (2020). Can brain natriuretic peptide, S100b, and interleukin-6 prognosticate the neurological consequences in Egyptian patients presented with supratentorial intracerebral hemorrhage?. Surgical neurology international, 11, 460. https://doi.org/10.25259/SNI_784_2020
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