The features of the composition of the gut microbiota in patients with hypertension and abdominal obesity

Authors

DOI:

https://doi.org/10.14739/2310-1237.2021.3.236979

Keywords:

gut microbiota, arterial hypertension, abdominal obesity

Abstract

The aim of this work was to study the features of the composition of the gut microbiota (GM) in patients with arterial hypertension (AH), which occurs against the background of abdominal obesity (AO).

Materials and methods. The paper presents the data on examination of 70 patients with AH of 2–3 degrees (46 patients with AO and 24 patients without obesity – with normal body weight (NBW)). The control group included 20 apparently healthy individuals with NBW. The patients underwent detailed standard clinical, laboratory and instrumental examination. Determination of the quantitative composition of GM was carried out by the method of polymerase chain reaction with hybridization-fluorescence detection of results in real time using the test system “COLONOFLOR-16 (biocenosis)” (“ALFA-LAB”). In this work, a statistical analysis of the obtained data was carried out using standard methods and Microsoft Excel 17.0.

Results. A significant change in the composition of GM were found in patients with AH, which proceeds against the background of AO, in comparison with apparently healthy individuals and with patients with AH without obesity (with NBW). In the group of AH patients with the presence of AO, significant decrease in the number of Lactobacillus spp., Bifidobacterium spp., Faecalibacterium prausnitzii and Аkkermansia muciniphila was found in comparison with apparently healthy individuals. The number of Faecalibacterium prausnitzii and Аkkermansia muciniphila in these patients was also significantly lower than in hypertensive patients with NBW. At the same time, the ratio of Bacteroides fragilis/Faecalibacterium prausnitzii was significantly higher than in the control group and the group of hypertensive patients without obesity – with NBW.

Conclusions. The results of the study indicate a possible role for the deficiency of such representatives of GM as Lactobacillus spp., Bifidobacterium spp., Faecalibacterium prausnitzii and Аkkermansia muciniphila and an increase in the ratio of Bacteroides fragilis/Faecalibacterium prausnitzii in the pathogenesis of AH, which occurs against the background of AO.

Author Biographies

S. M. Koval, GI “L. T. Malaya Therapy National Institute of the NAMS of Ukraine”, Kharkiv

MD, PhD, DSc, Professor, Head of the Department of Arterial Hypertension and Prevention of Its Complications

I. O. Snihurska, GI “L. T. Malaya Therapy National Institute of the NAMS of Ukraine”, Kharkiv

MD, PhD, Senior Researcher of the Department of Arterial Hypertension and Prevention of Its Complications

K. O. Yushko, GI “L. T. Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine”, Kharkiv

MD, PhD, Researcher of the Department of Arterial Hypertension and Prevention of Its Complications

O. V. Mysnychenko, GI “L. T. Malaya Therapy National Institute of the NAMS of Ukraine», Kharkiv

MD, PhD, Researcher of the Department of Hypertension and Prevention of Its Complications

V. Yu. Halchynska, GI “L. T. Malaya Therapy National Institute of the NAMS of Ukraine”, Kharkiv

PhD in Biology, Head of Laboratory of Immuno-Biochemical and Molecular Genetic Research

References

GBD 2015 Obesity Collaborators, Afshin, A., Forouzanfar, M. H., Reitsma, M. B., Sur, P., Estep, K., Lee, A., Marczak, L., Mokdad, A. H., Moradi-Lakeh, M., Naghavi, M., Salama, J. S., Vos, T., Abate, K. H., Abbafati, C., Ahmed, M. B., Al-Aly, Z., Alkerwi, A., Al-Raddadi, R., Amare, A. T., … Murray, C. (2017). Health Effects of Overweight and Obesity in 195 Countries over 25 Years. The New England journal of medicine, 377(1), 13-27. https://doi.org/10.1056/NEJMoa1614362

Williams, B., Mancia, G., Spiering, W., Agabiti Rosei, E., Azizi, M., Burnier, M., Clement, D. L., Coca, A., de Simone, G., Dominiczak, A., Kahan, T., Mahfoud, F., Redon, J., Ruilope, L., Zanchetti, A., Kerins, M., Kjeldsen, S. E., Kreutz, R., Laurent, S., Lip, G., … ESC Scientific Document Group (2018). 2018 ESC/ESH Guidelines for the management of arterial hypertension. European heart journal, 39(33), 3021-3104. https://doi.org/10.1093/eurheartj/ehy339

Shariq, O. A., & McKenzie, T. J. (2020). Obesity-related hypertension: a review of pathophysiology, management, and the role of metabolic surgery. Gland surgery, 9(1), 80-93. https://doi.org/10.21037/gs.2019.12.03

Mustafayeva, A. G. (2019). Mekhanizmy razvitiya arterial'noi gipertenzii u lits molodogo vozrasta s izbytochnym vesom [Mechanisms for the development of arterial hypertension in overweight adolescents and young adults]. Problems of Endocrinology, 65(3), 191-196. [in Russian]. https://doi.org/10.14341/probl9651

Ramalingam, L., Menikdiwela, K., LeMieux, M., Dufour, J. M., Kaur, G., Kalupahana, N., & Moustaid-Moussa, N. (2017). The renin angiotensin system, oxidative stress and mitochondrial function in obesity and insulin resistance. Biochimica et biophysica acta. Molecular basis of disease, 1863(5), 1106-1114. https://doi.org/10.1016/j.bbadis.2016.07.019

Koval, S. M., Miloslavsky, D. К., Snegurska, I. A., Mysnychenko, O. V., Penkova, M. Yu., & Schenyavska, Е. N. (2020). The association of T344C single nucleotide polymorphism of aldosterone synthase gene CYP11B2 (RS1799998) with clinical, hemodynamic and metabolic features of patients with arterial hypertension and abdominal obesity. Problemy endokrynnoi patologіi, (2), 44-50. https://doi.org/10.21856/j-PEP.2020.2.05

Koval, S. M., Snihurska, I. O., Vysotska, O., Strashnenko, H. M., Wójcik, W., & Dassibekov, K. (2019). Prognosis of essential hypertension progression in patients with abdominal obesity. In W. Wójcik, S. Pavlov, M. Kalimoldayev (Eds.) Information Technology in Medical Diagnostics II. Taylor & Francis Group. https://doi.org/10.1201/9780429057618-32

Lyzohub, V. H., Kramarova, V. N., & Melnychuk, I. O. (2019). Rol zmin mikrobioty kyshkivnyka v patohenezi sertsevo-sudynnykh zakhvoriuvan (ohliad literatury) [Role of intestinal microbiota changes in cardiovascular diseases pathogenesis]. Zaporozhye medical journal, 21(5), 672-678. [in Ukrainian]. https://doi.org/10.14739/2310-1210.2019.5.179462

Drapkina, O. M., & Shirobokikh, O. E. (2018). Rol' kishechnoi mikrobioty v patogeneze serdechno-sosudistykh zabolevanii i metabolicheskogo sindroma [Role of Gut Microbiota in the Pathogenesis of Cardiovascular Diseases and Metabolic Syndrome]. Ratsional'naya Farmakoterapiya v Kardiologii, 14(4), 567-574. [in Russian]. https://doi.org/10.20996/1819-6446-2018-14-4-567-574

Koval, S. M., Snihurska, I. O., & Yushko, K. O. (2020). Filotypy mikrobioty kyshechnyka u khvorykh na arterialnu hipertenziiu z abdominalnym ozhyrinniam [Philotypes of intestinal microbiotes in patients with arterial hypertension and abdominal obesity]. Pathologia, 17(3), 313-318. [in Ukrainian]. https://doi.org/10.14739/2310-1237.2020.3.221771

Sun, S., Lulla, A., Sioda, M., Winglee, K., Wu, M. C., Jacobs, D. R., Jr, Shikany, J. M., Lloyd-Jones, D. M., Launer, L. J., Fodor, A. A., & Meyer, K. A. (2019). Gut Microbiota Composition and Blood Pressure. Hypertension, 73(5), 998-1006. https://doi.org/10.1161/HYPERTENSIONAHA.118.12109

Koval, S. M., Yushko, K. O., & Snihurska, I. O. (2020). Kyshkova mikrobiota ta arterialna hipertenziia (ohliad literatury) [Gut microbiota and hypertension (a literature review]. Zaporozhye medical journal, 22(4), 561-567. [in Ukrainian]. https://doi.org/10.14739/2310-1210.2020.4.208409

Huart, J., Leenders, J., Taminiau, B., Descy, J., Saint-Remy, A., Daube, G., Krzesinski, J. M., Melin, P., de Tullio, P., & Jouret, F. (2019). Gut Microbiota and Fecal Levels of Short-Chain Fatty Acids Differ Upon 24-Hour Blood Pressure Levels in Men. Hypertension, 74(4), 1005-1013. https://doi.org/10.1161/HYPERTENSIONAHA.118.12588

Pluznick J. L. (2017). Microbial Short-Chain Fatty Acids and Blood Pressure Regulation. Current hypertension reports, 19(4), 25. https://doi.org/10.1007/s11906-017-0722-5

Pokrovskaya, E. V., Shamhalova, M. S., & Shestakova, M. V. (2019). Novye vzglyady na sostoyanie kishechnoi mikrobioty pri ozhirenii i sakharnom diabete 2 tipa [The new views on the state of the gut microbiota in obesity and diabetes mellitus type 2]. Sakharni Diabet, 22(3), 253-262. [in Russian]. https://doi.org/10.14341/DM10194

Obesity: preventing and managing the global epidemic. Report of a WHO consultation. (2000). World Health Organization technical report series, 894, i-253.

Heeney, D. D., Gareau, M. G., & Marco, M. L. (2018). Intestinal Lactobacillus in health and disease, a driver or just along for the ride?. Current opinion in biotechnology, 49, 140-147. https://doi.org/10.1016/j.copbio.2017.08.004

Ling, X., Linglong, P., Weixia, D., & Hong, W. (2016). Protective Effects of Bifidobacterium on Intestinal Barrier Function in LPS-Induced Enterocyte Barrier Injury of Caco-2 Monolayers and in a Rat NEC Model. PloS one, 11(8), e0161635. https://doi.org/10.1371/journal.pone.0161635

Liu, J., Zhang, D., Guo, Y., Cai, H., Liu, K., He, Y., Liu, Y., & Guo, L. (2020). The Effect of Lactobacillus Consumption on Human Blood Pressure: a Systematic Review and Meta-Analysis of Randomized Controlled Trials. Complementary therapies in medicine, 54, 102547. https://doi.org/10.1016/j.ctim.2020.102547

Ferreira-Halder, C. V., Faria, A., & Andrade, S. S. (2017). Action and function of Faecalibacterium prausnitzii in health and disease. Best practice & research. Clinical gastroenterology, 31(6), 643-648. https://doi.org/10.1016/j.bpg.2017.09.011

Liu, H., Wang, J., He, T., Becker, S., Zhang, G., Li, D., & Ma, X. (2018). Butyrate: A Double-Edged Sword for Health?. Advances in nutrition, 9(1), 21-29. https://doi.org/10.1093/advances/nmx009

Yang, T., Magee, K. L., Colon-Perez, L. M., Larkin, R., Liao, Y. S., Balazic, E., Cowart, J. R., Arocha, R., Redler, T., Febo, M., Vickroy, T., Martyniuk, C. J., Reznikov, L. R., & Zubcevic, J. (2019). Impaired butyrate absorption in the proximal colon, low serum butyrate and diminished central effects of butyrate on blood pressure in spontaneously hypertensive rats. Acta physiologica, 226(2), e13256. https://doi.org/10.1111/apha.13256

Gomez-Arango, L. F., Barrett, H. L., McIntyre, H. D., Callaway, L. K., Morrison, M., Dekker Nitert, M., & SPRING Trial Group (2016). Increased Systolic and Diastolic Blood Pressure Is Associated With Altered Gut Microbiota Composition and Butyrate Production in Early Pregnancy. Hypertension, 68(4), 974-981. https://doi.org/10.1161/HYPERTENSIONAHA.116.07910

Fadieienko, G. D., & Gridnyev, O. Y. (2020). Akkermansia muciniphila - rol u porushennі metabolіzmu [Akkermansia mucinifila and the part that it plays in metabolic disturbance]. Ukrainskyi terapevtychnyi zhurnal, (4), 55-62. [in Ukrainian]. https://doi.org/10.30978/UTJ2020-4-55

Fu, J., Bonder, M. J., Cenit, M. C., Tigchelaar, E. F., Maatman, A., Dekens, J. A., Brandsma, E., Marczynska, J., Imhann, F., Weersma, R. K., Franke, L., Poon, T. W., Xavier, R. J., Gevers, D., Hofker, M. H., Wijmenga, C., & Zhernakova, A. (2015). The Gut Microbiome Contributes to a Substantial Proportion of the Variation in Blood Lipids. Circulation research, 117(9), 817-824. https://doi.org/10.1161/CIRCRESAHA.115.306807

Geerlings, S. Y., Kostopoulos, I., de Vos, W. M., & Belzer, C. (2018). Akkermansia muciniphila in the Human Gastrointestinal Tract: When, Where, and How?. Microorganisms, 6(3), 75. https://doi.org/10.3390/microorganisms6030075

Yang, M., Bose, S., Lim, S., Seo, J., Shin, J., Lee, D., Chung, W. H., Song, E. J., Nam, Y. D., & Kim, H. (2020). Beneficial Effects of Newly Isolated Akkermansia muciniphila Strains from the Human Gut on Obesity and Metabolic Dysregulation. Microorganisms, 8(9), 1413. https://doi.org/10.3390/microorganisms8091413

Sitkin, S. I., Vakhitov, T. Ya., & Demyanova, E. V. Microbiome, gut dysbiosis and inflammatory bowel disease: That moment when the function is more important than taxonomy. Almanac of Clinical Medicine. 2018, 46(5), 396-425. [in Russian]. https://doi.org/10.18786/2072-0505-2018-46-5-396-425

Downloads

Published

2021-12-01

How to Cite

1.
Koval SM, Snihurska IO, Yushko KO, Mysnychenko OV, Halchynska VY. The features of the composition of the gut microbiota in patients with hypertension and abdominal obesity. Pathologia [Internet]. 2021Dec.1 [cited 2024Nov.9];18(3):303-10. Available from: http://pat.zsmu.edu.ua/article/view/236979

Issue

Vol. 18 No. 3 (2021): Pathologia

Section

Original research

License

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
Лицензия Creative Commons
    1. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

  1. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (SeeThe Effect of Open Access).