The features of the composition of the gut microbiota in patients with hypertension and abdominal obesity

Authors

DOI:

https://doi.org/10.14739/2310-1237.2021.3.236979

Keywords:

gut microbiota, arterial hypertension, abdominal obesity

Abstract

The aim of this work was to study the features of the composition of the gut microbiota (GM) in patients with arterial hypertension (AH), which occurs against the background of abdominal obesity (AO).

Materials and methods. The paper presents the data on examination of 70 patients with AH of 2–3 degrees (46 patients with AO and 24 patients without obesity – with normal body weight (NBW)). The control group included 20 apparently healthy individuals with NBW. The patients underwent detailed standard clinical, laboratory and instrumental examination. Determination of the quantitative composition of GM was carried out by the method of polymerase chain reaction with hybridization-fluorescence detection of results in real time using the test system “COLONOFLOR-16 (biocenosis)” (“ALFA-LAB”). In this work, a statistical analysis of the obtained data was carried out using standard methods and Microsoft Excel 17.0.

Results. A significant change in the composition of GM were found in patients with AH, which proceeds against the background of AO, in comparison with apparently healthy individuals and with patients with AH without obesity (with NBW). In the group of AH patients with the presence of AO, significant decrease in the number of Lactobacillus spp., Bifidobacterium spp., Faecalibacterium prausnitzii and Аkkermansia muciniphila was found in comparison with apparently healthy individuals. The number of Faecalibacterium prausnitzii and Аkkermansia muciniphila in these patients was also significantly lower than in hypertensive patients with NBW. At the same time, the ratio of Bacteroides fragilis/Faecalibacterium prausnitzii was significantly higher than in the control group and the group of hypertensive patients without obesity – with NBW.

Conclusions. The results of the study indicate a possible role for the deficiency of such representatives of GM as Lactobacillus spp., Bifidobacterium spp., Faecalibacterium prausnitzii and Аkkermansia muciniphila and an increase in the ratio of Bacteroides fragilis/Faecalibacterium prausnitzii in the pathogenesis of AH, which occurs against the background of AO.

Author Biographies

S. M. Koval, GI “L. T. Malaya Therapy National Institute of the NAMS of Ukraine”, Kharkiv

MD, PhD, DSc, Professor, Head of the Department of Arterial Hypertension and Prevention of Its Complications

I. O. Snihurska, GI “L. T. Malaya Therapy National Institute of the NAMS of Ukraine”, Kharkiv

MD, PhD, Senior Researcher of the Department of Arterial Hypertension and Prevention of Its Complications

K. O. Yushko, GI “L. T. Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine”, Kharkiv

MD, PhD, Researcher of the Department of Arterial Hypertension and Prevention of Its Complications

O. V. Mysnychenko, GI “L. T. Malaya Therapy National Institute of the NAMS of Ukraine», Kharkiv

MD, PhD, Researcher of the Department of Hypertension and Prevention of Its Complications

V. Yu. Halchynska, GI “L. T. Malaya Therapy National Institute of the NAMS of Ukraine”, Kharkiv

PhD in Biology, Head of Laboratory of Immuno-Biochemical and Molecular Genetic Research

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Published

2021-12-01

How to Cite

1.
Koval SM, Snihurska IO, Yushko KO, Mysnychenko OV, Halchynska VY. The features of the composition of the gut microbiota in patients with hypertension and abdominal obesity. Pathologia [Internet]. 2021Dec.1 [cited 2024Apr.26];18(3):303-10. Available from: http://pat.zsmu.edu.ua/article/view/236979

Issue

Vol. 18 No. 3 (2021): Pathologia

Section

Original research

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