Evaluation of Tru-Cut biopsy in differential diagnosis and challenges in breast adenoid cystic carcinoma on a case basis
DOI:
https://doi.org/10.14739/2310-1237.2022.2.245804Keywords:
breast carcinoma, tru cut biopsy, adenoid cystic carcinomaAbstract
Adenoid cystic carcinoma (AdCC) is a very rare low-grade invasive carcinoma primarily in the breast. The fact that similar patterns can be observed in invasive breast carcinomas (IВC) such as AdCC and breast ductal carcinoma in situ (DCIS) in Tru-Cut biopsies creates difficulties in the differential diagnosis.
Case presentation. A 70-year-old female patient was admitted to our outpatient clinic with the complaint of a palpable mass in the left breast subareolar region. In the light microscopy examination of 3 tissue samples with a size of 3 measurements, IBC-like tubular structures, some of which were formed by tiny uniform cells with narrow cytoplasm, and some with eosinophilic material, and solid nest structures suggesting DCIS in focal areas were observed.
Immunohistochemical examination showed continuity of myoepithelial cells with p63 and calponin, and epithelial cells, staining with Cd117 and CK7. No staining was observed with progesterone, estrogen, and Cerbb2. The staining rate of Ki-67 was determined as 2 percent. A diagnosis of AdCC was made with these findings.
Conclusions. It is important to search for different patterns in addition to double cell population and pay attention to the material in the lumens in breast Tru-Cut biopsies that contain AdCC patterns that may cause the diagnosis of IBC and DCIS in error.
References
WHO Classification of Tumours Editorial Board. (2019, December 3). Breast Tumours: WHO Classification of Tumours (Medicine) (5th ed.). World Health Organization.
Ghabach, B., Anderson, W. F., Curtis, R. E., Huycke, M. M., Lavigne, J. A., & Dores, G. M. (2010). Adenoid cystic carcinoma of the breast in the United States (1977 to 2006): a population-based cohort study. Breast cancer research : BCR, 12(4), R54. https://doi.org/10.1186/bcr2613
Miyai, K., Schwartz, M. R., Divatia, M. K., Anton, R. C., Park, Y. W., Ayala, A. G., & Ro, J. Y. (2014). Adenoid cystic carcinoma of breast: Recent advances. World journal of clinical cases, 2(12), 732-741. https://doi.org/10.12998/wjcc.v2.i12.732
Treitl, D., Radkani, P., Rizer, M., El Hussein, S., Paramo, J. C., & Mesko, T. W. (2018). Adenoid cystic carcinoma of the breast, 20 years of experience in a single center with review of literature. Breast cancer, 25(1), 28-33. https://doi.org/10.1007/s12282-017-0780-1
Yang, C., Zhang, L., & Sanati, S. (2019). SOX10 Is a Sensitive Marker for Breast and Salivary Gland Adenoid Cystic Carcinoma: Immunohistochemical Characterization of Adenoid Cystic Carcinomas. Breast cancer : basic and clinical research, 13, 1178223419842185. https://doi.org/10.1177/1178223419842185
Defaud-Hénon, F., Tunon-de-Lara, C., Fournier, M., Marty, M., Velasco, V., de Mascarel, I., & MacGrogan, G. (2010). Le carcinome adénoïde kystique du sein: étude clinique, histologique, immunohistochimique et revue de la littérature [Adenoid cystic carcinoma of the breast: clinical, histological and immunohistochemical characterization]. Annales de pathologie, 30(1), 7-16. https://doi.org/10.1016/j.annpat.2010.01.003
Poling, J. S., Yonescu, R., Subhawong, A. P., Sharma, R., Argani, P., Ning, Y., & Cimino-Mathews, A. (2017). MYB Labeling by Immunohistochemistry Is More Sensitive and Specific for Breast Adenoid Cystic Carcinoma than MYB Labeling by FISH. The American journal of surgical pathology, 41(7), 973-979. https://doi.org/10.1097/PAS.0000000000000878
Downloads
Published
How to Cite
Issue
Section
License
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.