Vegetative and electrical disorders in women with chronic coronary syndrome depending on the state of bone mineral density
DOI:
https://doi.org/10.14739/2310-1237.2022.2.254816Keywords:
chronic coronary syndrome, osteopenia, osteoporosis, disorders of the autonomic nervous system, arrhythmiaAbstract
Aim: to determine the features of heart rate variability and electrical changes in the myocardium in women with chronic coronary syndrome, depending on the state of the bone mineral density (BMD).
Materials and methods. 121 women with chronic coronary syndrome (CCS): stable exertional angina of II–III functional class (FC) (mean age 68.0 (60.0; 75.0) years) were examined and divided into 3 groups: group 1 − 30 women with ССS and normal BMD; group 2 – 33 women with CCS and osteopenia (OPе); group 3 – 58 women with CCS and osteoporosis (OP). All patients underwent daily ECG monitoring and ultrasound osteodensitometry.
Results. In women with CCS and OP, increase in the frequency (by 2.9 times; P < 0.05) and duration (by 2.3 times; P < 0.05) of tachycardia episodes, the frequency of registration of ventricular and supraventricular extrasystole episodes (by 8.1 time and 1.2 times, respectively; P < 0.05) if compared to patients without BMD disorders was found. In women with СCS and OPе there was a tendency to increase in these indicators, which did not reach the level of statistical significance. The presence of BMD disorders in patients with CCS was accompanied with decrease in total HRV activity (RMSSD and HRVT), the development of the predominance of ANS sympathetic domain activity, as evidenced by an increase in LF by 44.3 % at the daytime and 44.0 % at night, decrease in HF 2.3 times during the day and 2.1 times at night in patients with OPe and OP, respectively. According to the correlation analysis data, the presence of correlations between the state of BMD and indicators of electrical and autonomic activity of the myocardium was established.
Conclusions. In postmenopausal women with CCS, the severity of autonomic and electrical disorders is associated with the degree of bone disorders and is maximal in osteoporosis.
References
Timmis, A., Townsend, N., Gale, C. P., Torbica, A., Lettino, M., Petersen, S. E., Mossialos, E. A., Maggioni, A. P., Kazakiewicz, D., May, H. T., De Smedt, D., Flather, M., Zuhlke, L., Beltrame, J. F., Huculeci, R., Tavazzi, L., Hindricks, G., Bax, J., Casadei, B., Achenbach, S., … European Society of Cardiology (2020). European Society of Cardiology: Cardiovascular Disease Statistics 2019. European heart journal, 41(1), 12-85. https://doi.org/10.1093/eurheartj/ehz859
Lyakhotska, A. V. (2017). Porivnyalna kharakterystyka zmin trombotsytarnoho hemostazu khvorykh na stabilni formy ishemichnoi khvoroby sertsia v zalezhnosti vid indyvidualnoyi chutlyvosti do antytrombotsytarnoho likuvannia [Comparative characteristics of changes in platelet hemostasis in patients with stable forms of coronary heart disease depending on individual sensitivity to antiplatelet therapy]. ScienceRise: Medical Sciense, (11), 31-36. [in Ukrainian]. https://doi.org/10.15587/2519-4798.2017.116580
Chystyk, T. V. (2020). Sympatychnyi overdraiv yak hlobalna problema sertsevo-sudynnykh zakhvoriuvan [Sympathetic overdrive as a global problem of cardiovascular disease]. Arterialna hipertenziia, 13(6), 47-51. [in Ukrainian].
Cherpita, V. O. (2021). Kliniko-anamnestychna kharakterystyka ta osoblyvosti metabolizmu homotsysteinu u zhinok iz tsukrovym diabetom 2-ho typu ta osteoartrozom v pre- ta postmenopauzi [Clinical and anamnestic characteristics and peculiarities of homocysteine metabolism in women with type 2 diabetes mellitus and osteoarthritis in the pre- and post-menopause periods]. Ukrayinskyi revmatolohichniy zhurnal, (4), 27-31. [in Ukrainian]. https://doi.org/10.32471/rheumatology.2707-6970.86.16470
Serin, Y., & Acar Tek, N. (2019). Effect of Circadian Rhythm on Metabolic Processes and the Regulation of Energy Balance. Annals of nutrition & metabolism, 74(4), 322-330. https://doi.org/10.1159/000500071
Khyts, A. (2020). Postmenopauzalnyi osteoporoz: farmakolohichne likuvannia [Postmenopausal osteoporosis: pharmacological treatment]. Ukrayinskyi medychnyi chasopys, 2(3), 55-56. [in Ukrainian].
Mykhailovska, N. S., & Miniailenko, L. Ye. (2017). The state of vascular endothelium, clinical and metabolic features of patients with coronary heart disease combined with nonalcoholic fatty liver disease. Pathologia, 14(1), 62-67 https://doi.org/10.14739/2310-1237.2017.1.97505
Dimitri, P., & Rosen, C. (2017). The Central Nervous System and Bone Metabolism: An Evolving Story. Calcified tissue international, 100(5), 476-485. https://doi.org/10.1007/s00223-016-0179-6
Athimulam, S., & Bancos, I. (2019). Evaluation of bone health in patients with adrenal tumors. Current opinion in endocrinology, diabetes, and obesity, 26(3), 125-132. https://doi.org/10.1097/MED.0000000000000478
Hofbauer, L. C., & Henneicke, H. (2018). β-Blockers and bone health. The Journal of clinical investigation, 128(11), 4745-4747. https://doi.org/10.1172/JCI122992
Hamajima, K., Hamamura, K., Chen, A., Yokota, H., Mori, H., Yo, S., Kondo, H., Tanaka, K., Ishizuka, K., Kodama, D., Hirai, T., Miyazawa, K., Goto, S., & Togari, A. (2018). Suppression of osteoclastogenesis via α2-adrenergic receptors. Biomedical reports, 8(5), 407-416. https://doi.org/10.3892/br.2018.1075
Guzon-Illescas, O., Perez Fernandez, E., Crespí Villarias, N., Quirós Donate, F. J., Peña, M., Alonso-Blas, C., García-Vadillo, A., & Mazzucchelli, R. (2019). Mortality after osteoporotic hip fracture: incidence, trends, and associated factors. Journal of orthopaedic surgery and research, 14(1), 203. https://doi.org/10.1186/s13018-019-1226-6
Mykhailovska, N. S., & Stetsiuk, І. О. (2019) The interrelationship between the cardiovascular remodeling indicators and the state of bone mineral density in women with coronary artery disease. Pathologia, 16(1), 53-59. https://doi.org/10.14739/2310-1237.2019.1.166296
Mykhailovska, N. S., Stetsiuk, I. O., Kulynych, T. O. & Fedoniuk, L. Y. (2020). The diagnostic and prognostic value of biomarkers in women with coronary artery disease and osteoporosis. Archives of the Balkan Medical Union, 55(1), 31-39. https://doi.org/10.31688/ABMU.2020.55.1.03
Mykhailovska, N. S., Stetsiuk, I. O., Kulynych, T. O., Gorbachova, S. V., & Zhulkevych, I. V. (2020). The interrelationship of the bone and cardiovascular remodeling biomarkers and clinical peculiarities of coronary artery disease in postmenopausal women. Reumatologia, 58(3), 142-149. https://doi.org/10.5114/reum.2020.96687
Lisun, Y. B., & Uhlev Y. I. (2020). Variabelnist sertsevoho rytmu, vykorystannia ta metody analizu [Heart rate variability, applying and methods of analysis]. Pain, Anaesthesia & Intensive Care, (4), 83-89. [in Ukrainian]. https://doi.org/10.25284/2519-2078.4(93).2020.220693
Zharikova Yu. V. (2021). Endokrynni aspekty rozladiv snu ta nespannia [Endocrine aspects of sleep and wakefulness disorders]. Ukrainskyi medychnyi chasopys. [in Ukrainian]. https://www.umj.com.ua/article/212145/endokrinni-aspekti-rozladiv-snu-ta-nespannya
Zaremba, E. H., Karplyak, V. M., Virna, M. M., Zaremba-Fedchyshyn, O. V., & Zaremba, O. V. (2018). Patohenetychne obgruntuvannia zastosuvannia metabolichnoi terapii u patsiientiv z khronichnoiu ishemichnoiu khvoroboiu sertsia [Pathogenetic substantiation of metabolic theatment for patients with ischemic heart disease]. Liky Ukrainy, (7), 46-50. [in Ukrainian]. https://doi.org/10.37987/1997-9894.2018.7(223).199778
Stein, P. K., Buzkova, P., Fink, H. A., Robbins, J. A., Mukamal, K. J., Cauley, J. A., Carbone, L., Elam, R., McMillan, D. W., Valderrabano, R., & Barzilay, J. I. (2021). Cardiovascular autonomic nervous system function and hip fracture risk: the Cardiovascular Health Study. Archives of osteoporosis, 16(1), 163. https://doi.org/10.1007/s11657-021-01028-y
Kiselev, A. R., & Karavaev, A. S. (2020). The intensity of oscillations of the photoplethysmographic waveform variability at frequencies 0.04-0.4 Hz is effective marker of hypertension and coronary artery disease in males. Blood pressure, 29(1), 55-62. https://doi.org/10.1080/08037051.2019.1645586
Abdelnaby, M. H. (2018). Effect of percutaneous coronary intervention on heart rate variability in coronary artery disease patients. European Cardiology Review , 13(1), 60-61. https://doi.org/10.15420/ecr.2018.13.2
Elefteriou, F. (2018). Impact of the Autonomic Nervous System on the Skeleton. Physiological reviews, 98(3), 1083-1112. https://doi.org/10.1152/physrev.00014.2017
Kim, B. J., Kwak, M. K., Kim, J. S., Lee, S. H., & Koh, J. M. (2018). Higher sympathetic activity as a risk factor for skeletal deterioration in pheochromocytoma. Bone, 116, 1-7. https://doi.org/10.1016/j.bone.2018.06.023
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