Nutrition and cancer: modern aspects of a healthy lifestyle (literature review)

Authors

DOI:

https://doi.org/10.14739/2310-1237.2022.2.258362

Keywords:

food, diet, cancer, ketogenic diet, Mediterranean diet, fasting

Abstract

Despite significant improvements in screening, diagnosis and targeted therapy, cancer remains the second leading cause of death in the world. It is becoming increasingly clear that diet and lifestyle play a significant role in the development and progression of cancer. Thus, various dietary combinations can be proposed to reduce the risk of cancer and to improve the impact of basic therapy. Nutrition is closely linked to cancer. Food carcinogens, macronutrients, micronutrients such as vitamins A, C and D, dietary fiber, modulation of metabolism by diet, dietary supplements and anticancer agents in food affect the development of cancer. This article discusses research on the relationship between nutrition and cancer, as well as current dietary guidelines for reducing the risk of cancer.

The aim of the study is to analyze information from the professional literature on the influence of various nutritional regimes in cancer patients.

Conclusions. Proper nutrition can prevent the risk of cancer and improve the impact of treatment on the disease. Ketogenic diet is useful in combination with standard therapy on the basis of its ability to enhance the antitumor effects of classical chemotherapy and radiation therapy, its overall good safety and tolerability, as well as improving the quality of life. Mediterranean diet is a protective factor against cancer, due to the antioxidant and anti-inflammatory properties of the ingredients. Fasting is also a potentially effective strategy for inducing the differential stress resistance of cancer and normal cells as an adjunct to standard treatment. Promising benefits of vitamins in the prevention and treatment of cancer can be achieved through the use of new potent analogues, as well as combinations of vitamins in the early stages of cancer.

 

Author Biographies

O. P. Kolesnik, Zaporizhzhia State Medical University, Ukraine

MD, PhD, DSc, Professor, Head of the Department of Oncology and Surgical Oncology; Oncologist, Oncosurgeon, Oncolife LLC, Zaporizhzhia, Ukraine

O. M. Levyk, Zaporizhzhia State Medical University, Ukraine

MD, PhD, Associate Professor of the Department of Oncology and Surgical Oncology; Oncologist, Oncolife LLC, Zaporizhzhia, Ukrain

D. Ye. Cherniavskyi, Zaporizhzhia State Medical University, Ukraine

MD, PhD student, Department of Oncology and Surgical Oncology; Oncologist, Oncolife LLC, Zaporizhzhia, Ukraine

V. O. Kuzmenko, Zaporizhzhia State Medical University, Ukraine

MD, Assistant of the Department of Oncology and Surgical Oncology; Oncologist, Oncolife LLC, Zaporizhzhia, Ukraine

L. S. Lytvynenko, Zaporizhzhia State Medical University, Ukraine

MD

References

Stenger, M. (2022, January 13). Global Burden of Cancer From 2010 to 2019. The ASCO post. https://ascopost.com/news/january-2022/global-burden-of-cancer-from-2010-to-2019/

Fedorenko, Z. P., Mikhailovich, Y. Y., Gulak, L. O., Horokh, Ye. L., Ryzhov, A. Yu., Sumkina, O. V., & Kutsenko, L. B. (2021). Rak v Ukraini, 2019-2020. Zakhvoriuvanist, smertnist, pokaznyky diialnosti onkolohichnoi sluzhby [Cancer in Ukraine, 2019-2020. Morbidity, mortality, indicators of oncology service]. Bulletin of the National Cancer Registry of Ukraine, 22. [in Ukrainian]. http://www.ncru.inf.ua/publications/BULL_22/index.htm

Aprile, G., Basile, D., Giaretta, R., Schiavo, G., La Verde, N., Corradi, E., Monge, T., Agustoni, F., & Stragliotto, S. (2021). The Clinical Value of Nutritional Care before and during Active Cancer Treatment. Nutrients, 13(4), 1196. https://doi.org/10.3390/nu13041196

World Health Organization. (2022, February 3). Cancer. WHO. https://www.who.int/news-room/fact-sheets/detail/cancer

Weber, D. D., Aminzadeh-Gohari, S., Tulipan, J., Catalano, L., Feichtinger, R. G., & Kofler, B. (2020). Ketogenic diet in the treatment of cancer - Where do we stand?. Molecular metabolism, 33, 102-121. https://doi.org/10.1016/j.molmet.2019.06.026

Plotti, F., Terranova, C., Luvero, D., Bartolone, M., Messina, G., Feole, L., Cianci, S., Scaletta, G., Marchetti, C., Di Donato, V., Fagotti, A., Scambia, G., Benedetti Panici, P., & Angioli, R. (2020). Diet and Chemotherapy: The Effects of Fasting and Ketogenic Diet on Cancer Treatment. Chemotherapy, 65(3-4), 77-84. https://doi.org/10.1159/000510839

Oliveira, C., Mattingly, S., Schirrmacher, R., Sawyer, M. B., Fine, E. J., & Prado, C. M. (2018). A Nutritional Perspective of Ketogenic Diet in Cancer: A Narrative Review. Journal of the Academy of Nutrition and Dietetics, 118(4), 668–688. https://doi.org/10.1016/j.jand.2017.02.003

Weber, D. D., Aminazdeh-Gohari, S., & Kofler, B. (2018). Ketogenic diet in cancer therapy. Aging, 10(2), 164-165. https://doi.org/10.18632/aging.101382

Cohen, C. W., Fontaine, K. R., Arend, R. C., Soleymani, T., & Gower, B. A. (2018). Favorable Effects of a Ketogenic Diet on Physical Function, Perceived Energy, and Food Cravings in Women with Ovarian or Endometrial Cancer: A Randomized, Controlled Trial. Nutrients, 10(9), 1187. https://doi.org/10.3390/nu10091187

Klement, R. J., Champ, C. E., Kämmerer, U., Koebrunner, P. S., Krage, K., Schäfer, G., Weigel, M., & Sweeney, R. A. (2020). Impact of a ketogenic diet intervention during radiotherapy on body composition: III-final results of the KETOCOMP study for breast cancer patients. Breast cancer research : BCR, 22(1), 94. https://doi.org/10.1186/s13058-020-01331-5

Talib, W. H., Mahmod, A. I., Kamal, A., Rashid, H. M., Alashqar, A., Khater, S., Jamal, D., & Waly, M. (2021). Ketogenic Diet in Cancer Prevention and Therapy: Molecular Targets and Therapeutic Opportunities. Current issues in molecular biology, 43(2), 558-589. https://doi.org/10.3390/cimb43020042

Mentella, M. C., Scaldaferri, F., Ricci, C., Gasbarrini, A., & Miggiano, G. (2019). Cancer and Mediterranean Diet: A Review. Nutrients, 11(9), 2059. https://doi.org/10.3390/nu11092059

Farinetti, A., Zurlo, V., Manenti, A., Coppi, F., & Mattioli, A. V. (2017). Mediterranean diet and colorectal cancer: A systematic review. Nutrition, 43-44, 83-88. https://doi.org/10.1016/j.nut.2017.06.008

Tosti, V., Bertozzi, B., & Fontana, L. (2018). Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms. The journals of gerontology. Series A, Biological sciences and medical sciences, 73(3), 318-326. https://doi.org/10.1093/gerona/glx227

Mirabelli, M., Chiefari, E., Arcidiacono, B., Corigliano, D. M., Brunetti, F. S., Maggisano, V., Russo, D., Foti, D. P., & Brunetti, A. (2020). Mediterranean Diet Nutrients to Turn the Tide against Insulin Resistance and Related Diseases. Nutrients, 12(4), 1066. https://doi.org/10.3390/nu12041066

Turati, F., Carioli, G., Bravi, F., Ferraroni, M., Serraino, D., Montella, M., Giacosa, A., Toffolutti, F., Negri, E., Levi, F., & La Vecchia, C. (2018). Mediterranean Diet and Breast Cancer Risk. Nutrients, 10(3), 326. https://doi.org/10.3390/nu10030326

Cho, A. R., Choi, W. J., Kwon, Y. J., Lee, H. S., Ahn, S. G., & Lee, J. W. (2020). Mediterranean Diet and Naltrexone/Bupropion Treatment for Weight Loss in Overweight and Obese Breast Cancer Survivors and Non-Cancer Participants: A Pilot Randomized Controlled Trial. Diabetes, metabolic syndrome and obesity : targets and therapy, 13, 3325-3335. https://doi.org/10.2147/DMSO.S269237

Nencioni, A., Caffa, I., Cortellino, S., & Longo, V. D. (2018). Fasting and cancer: molecular mechanisms and clinical application. Nature reviews. Cancer, 18(11), 707-719. https://doi.org/10.1038/s41568-018-0061-0

Sadeghian, M., Rahmani, S., Khalesi, S., & Hejazi, E. (2021). A review of fasting effects on the response of cancer to chemotherapy. Clinical nutrition, 40(4), 1669-1681. https://doi.org/10.1016/j.clnu.2020.10.037

Clifton, K. K., Ma, C. X., Fontana, L., & Peterson, L. L. (2021). Intermittent fasting in the prevention and treatment of cancer. CA: a cancer journal for clinicians, 71(6), 527-546. https://doi.org/10.3322/caac.21694

De Groot, S., Lugtenberg, R. T., Cohen, D., Welters, M., Ehsan, I., Vreeswijk, M., Smit, V., de Graaf, H., Heijns, J. B., Portielje, J., van de Wouw, A. J., Imholz, A., Kessels, L. W., Vrijaldenhoven, S., Baars, A., Kranenbarg, E. M., Carpentier, M. D., Putter, H., van der Hoeven, J., Nortier, J., … Dutch Breast Cancer Research Group (BOOG) (2020). Fasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trial. Nature communications, 11(1), 3083. https://doi.org/10.1038/s41467-020-16138-3

Zorn, S., Ehret, J., Schäuble, R., Rautenberg, B., Ihorst, G., Bertz, H., Urbain, P., & Raynor, A. (2020). Impact of modified short-term fasting and its combination with a fasting supportive diet during chemotherapy on the incidence and severity of chemotherapy-induced toxicities in cancer patients - a controlled cross-over pilot study. BMC cancer, 20(1), 578. https://doi.org/10.1186/s12885-020-07041-7

Clement, D. S., Tesselaar, M. E., van Leerdam, M. E., Srirajaskanthan, R., & Ramage, J. K. (2019). Nutritional and vitamin status in patients with neuroendocrine neoplasms. World journal of gastroenterology, 25(10), 1171-1184. https://doi.org/10.3748/wjg.v25.i10.1171

Glorieux, C., & Buc Calderon, P. (2021). Vitamin C (Ascorbate) and Redox Topics in Cancer. Antioxidants & redox signaling, 35(14), 1157-1175. https://doi.org/10.1089/ars.2020.8233

Böttger, F., Vallés-Martí, A., Cahn, L., & Jimenez, C. R. (2021). High-dose intravenous vitamin C, a promising multi-targeting agent in the treatment of cancer. Journal of experimental & clinical cancer research : CR, 40(1), 343. https://doi.org/10.1186/s13046-021-02134-y

Van Gorkom, G., Lookermans, E. L., van Elssen, C., & Bos, G. (2019). The Effect of Vitamin C (Ascorbic Acid) in the Treatment of Patients with Cancer: A Systematic Review. Nutrients, 11(5), 977. https://doi.org/10.3390/nu11050977

Bazzan, A. J., Zabrecky, G., Wintering, N., Newberg, A. B., & Monti, D. A. (2018). Retrospective Evaluation of Clinical Experience With Intravenous Ascorbic Acid in Patients With Cancer. Integrative cancer therapies, 17(3), 912-920. https://doi.org/10.1177/1534735418775809

Bahrami, A., & Sahebkar, A. (2020). Vitamin D as a Potential Therapeutic Option in Cancer Treatment: Is There a Role for Chemoprevention?. Anti-cancer agents in medicinal chemistry, 20(18), 2138-2149. https://doi.org/10.2174/1871520620999200729192728

Li, Z., Shi, J., Wang, Z., Chen, H., & Liu, Y. (2021). Nutrient Status of Vitamin D among Cancer Patients. Zhongguo fei ai za zhi = Chinese journal of lung cancer, 24(5), 345-350. https://doi.org/10.3779/j.issn.1009-3419.2021.101.10

Markowska, A., Antoszczak, M., Kojs, Z., Bednarek, W., Markowska, J., & Huczyński, A. (2020). Role of vitamin D3 in selected malignant neoplasms. Nutrition, 79-80, 110964. https://doi.org/10.1016/j.nut.2020.110964

McDonnell, S. L., Baggerly, C. A., French, C. B., Baggerly, L. L., Garland, C. F., Gorham, E. D., Hollis, B. W., Trump, D. L., & Lappe, J. M. (2018). Breast cancer risk markedly lower with serum 25-hydroxyvitamin D concentrations ≥60 vs <20 ng/ml (150 vs 50 nmol/L): Pooled analysis of two randomized trials and a prospective cohort. PloS one, 13(6), e0199265. https://doi.org/10.1371/journal.pone.0199265

Li, K., & Zhang, B. (2020). The association of dietary β-carotene and vitamin A intake on the risk of esophageal cancer: a meta-analysis. Revista espanola de enfermedades digestivas, 112(8), 620-626. https://doi.org/10.17235/reed.2020.6699/2019

Wang, Q., & He, C. (2020). Dietary vitamin A intake and the risk of ovarian cancer: a meta-analysis. Bioscience reports, 40(4), BSR20193979. https://doi.org/10.1042/BSR20193979

Tratnjek, L., Jeruc, J., Romih, R., & Zupančič, D. (2021). Vitamin A and Retinoids in Bladder Cancer Chemoprevention and Treatment: A Narrative Review of Current Evidence, Challenges and Future Prospects. International journal of molecular sciences, 22(7), 3510. https://doi.org/10.3390/ijms22073510

He, J., Gu, Y., & Zhang, S. (2018). Vitamin A and Breast Cancer Survival: A Systematic Review and Meta-analysis. Clinical breast cancer, 18(6), e1389-e1400. https://doi.org/10.1016/j.clbc.2018.07.025

Published

2022-08-22

How to Cite

1.
Kolesnik OP, Levyk OM, Cherniavskyi DY, Kuzmenko VO, Lytvynenko LS. Nutrition and cancer: modern aspects of a healthy lifestyle (literature review). Pathologia [Internet]. 2022Aug.22 [cited 2024Dec.26];19(2):135-41. Available from: http://pat.zsmu.edu.ua/article/view/258362

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Section

Review