Comparative evaluation of the impact of candesartan and ramipril therapy on the levels of GDF 15 and NTproBNP, structural and functional performance of the heart in patients with coronary artery disease with asymptomatic diastolic dysfunction after myocar
DOI:
https://doi.org/10.14739/2310-1237.2014.1.25956Keywords:
diastole, candesartan, ramipril, myocardial infarction, hypertensionAbstract
Aims. Diastolic dysfunction of the left ventricle in patients with coronary artery disease affects the prognosis and is associated with the frequency of hospitalization for first arisen heart failure.
Methods and results. In order to assess the relative impact of candesartan and ramipril initially and after 12 weeks of therapy in 31 patients with coronary artery disease with asymptomatic diastolic dysfunction (ejection fraction>45%), after myocardial infarction with concomitant arterial hypertension, structural and functional changes of the heart were studied using echocardiography and levels of GDF 15 and NTproBNP were studied using ELISA. We found that taking candesartan and ramipril contributed to improving diastolic function with decreasing index of left atrial volume and the ratio E/E ' and an increase in E'.
Conclusion. Appointment of candesartan and ramipril led to the significant reduction in GDF 15. This indicates the comparable positive effect of these drugs on the level of GDF 15 and structural and functional performance of the heart.
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