Results of patient survival after surgical interventions for complicated forms of colon cancer performed in general surgical hospitals

Authors

DOI:

https://doi.org/10.14739/2310-1237.2024.1.300184

Keywords:

colon cancer, complications, surgery, survival, mortality

Abstract

The aim of the study: to evaluate the 1- and 3-year survival of patients operated for complicated forms of colon cancer (СC) in general surgical hospital.

Materials and methods. The study group included 71 (100 %) patients with complicated forms of СС. Acute intestinal obstruction was detected in 49 (69.1 %) patients, tumor perforation – in 13 (18.3 %), acute colonic bleeding – in 3 (4.2 %) patients, a combination of acute intestinal obstruction with tumor perforation – in 4 (5.6 %) and intestinal obstruction with bleeding – in 2 (2.8 %) operated patients. Radical operations were performed in 48 (67.6 %) patients, palliative operations – in 18 (25.4 %), symptomatic operations – in 5 (7.0 %) patients. II stage of the disease was diagnosed in 15 (21.1 %), III stage – in 32 (45.1 %), IV stage – in 24 (33.8 %) operated patients. 19 (30.2 %) patients underwent specific chemotherapy after surgery.

Results. Among patients with the II stage of the oncological process 1-year survival was 76.9 ± 11.7 %, 3-year – 53.8 ± 13.8 %; with stage III, 1-year survival was 65.6 ± 8.4 %, 3-year – 50.0 ± 8.8 %; in persons with IV stage of СC – 29.2 ± 9.3 % and 8.3 ± 2.6 % respectively (χ2 = 21.8, p = 0.0001). Among male patients, 1-year survival was 51.4 ± 8.5 %, 3-year – 31.4 ± 7.9 %; women – 61.1 ± 8.1 % and 44.4 ± 8.3 %, respectively (χ2 = 2.3, p = 0.1302). Better indicators were found in the case of cancer of the left sections of the large intestine than the right sections – the 1-year survival rate was 60.4 ± 7.1 % and 43.5 ± 10.3 % respectively; 3-year – 39.6 ± 7.1 % and 30.4 ± 9.6 % (χ2 = 0.74, p = 0.3906).

Conclusions. The conducted analysis indicates a clear dependence of the survival results on the stage of the disease, gender and localization of the tumor process.

Author Biographies

M. A. Kubrak, Zaporizhzhia State Medical and Pharmaceutical University, Ukraine

MD, PhD, Associate Professor of the Department of General Surgery and Postgraduate Surgical Education, Educational and Scientific Institute of Postgraduate Education

S. M. Zavhorodnii, Zaporizhzhia State Medical and Pharmaceutical University, Ukraine

MD, PhD, DSc, Professor of the Department of General Surgery and Postgraduate Surgical Education, Educational and Scientific Institute of Postgraduate Education

M. B. Danyliuk, Zaporizhzhia State Medical and Pharmaceutical University, Ukraine

MD, PhD, Associate Professor of the Department of General Surgery and Postgraduate Surgical Education, Educational and Scientific Institute of Postgraduate Education

References

Yakovtsova II, Yakimenko АS, Ivakhno IV, Danyliuk SV, Dolgaya OV, Chertenko TM. [Analysis of mortality of patients with colorectal cancer in Kharkiv`s multidisciplinary hospitals]. Klinichna onkolohiia. 2020;10(3):1-4. Ukrainian. doi: https://doi.org/10.32471/clinicaloncology.2663-466X.39-3.27380

Ukrainian cancer registry statistics. [Cancer in Ukraine, 2020-2021. Occupation, death, demonstration of oncological service]. Bulletin of National Cancer Registry of Ukraine. 2022;23. Ukrainian. Available from: http://www.ncru.inf.ua/publications/BULL_23/PDF/BULL_23.pdf

Kolesnik AP, Kolesnіk IP, Kechedzhyiev VV. [Survival analysis of elderly and senile patients with colon cancer of II–III stages]. Modern Medical Technology. 2019;(1):60-5. Russian. doi: https://doi.org/10.34287/MMT.1(40).2019.10

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71(3):209-49. doi: https://doi.org/10.3322/caac.21660

Michailovich YI, Zvirych VV, Kolesnik OO. [Colorectal cancer screening as a consensus resolution to the problem of locally advancedcolon and rectal cancer in Ukraine. Controversies and questions]. Klinichna onkolohiia. 2017;(4):13-8. Ukrainian. Available from: https://www.clinicaloncology.com.ua/wp/wp-content/uploads/2017/12/642.pdf

Kubrak MA, Zavhorodnii SM, Danyliuk MB. [Problems of staging complicated forms of colon carcinoma in patients who were urgently operated in a general surgical hospital]. Pathologia 2023;20(1):45-9. Ukrainian. doi: https://doi.org/10.14739/2310-1237.2023.1.273868

Yang KM, Jeong MJ, Yoon KH, Jung YT, Kwak JY. Oncologic outcome of colon cancer with perforation and obstruction. BMC gastroenterol. 2022;22(1):247. doi: https://doi.org/10.1186/s12876-022-02319-5

Krogsgaard M, Kristensen HØ, Furnée EJ, Verkuijl SJ, Rama NJ, Domingos H, et al. Life with a stoma across five European countries-a cross-sectional study on long-term rectal cancer survivors. Support Care Cancer. 2022;30(11):8969-79. doi: https://doi.org/10.1007/s00520-022-07293-y

Xu Z, Becerra AZ, Aquina CT, Hensley BJ, Justiniano CF, Boodry C, et al. Emergent Colectomy Is Independently Associated with Decreased Long-Term Overall Survival in Colon Cancer Patients. J Gastrointest Surg. 2017;21(3):543-53. doi: https://doi.org/10.1007/s11605-017-3355-8

Antony P, Harnoss JC, Warschkow R, Schmied BM, Schneider M, Tarantino I, et al. Urgent surgery in colon cancer has no impact on survival. J Surg Oncol. 2019;119(8):1170-8. doi: https://doi.org/10.1002/jso.25469

Aguiar Junior S, Oliveira MM, Silva DR, Mello CA, Calsavara VF, Curado MP. Survival of patients with colorectal cancer in a cancer center. Arq Gastroenterol. 2020;57(2):172-7. doi: https://doi.org/10.1590/S0004-2803.202000000-32

Li N, Lu B, Luo C, Cai J, Lu M, Zhang Y, et al. Incidence, mortality, survival, risk factor and screening of colorectal cancer: A comparison among China, Europe, and northern America. Cancer Lett. 2021;522:255-68. doi: https://doi.org/10.1016/j.canlet.2021.09.034

Coughlin SS. Social determinants of colorectal cancer risk, stage, and survival: a systematic review. Int J Colorectal Dis. 2020;35(6):985-95. doi: https://doi.org/10.1007/s00384-020-03585-z

Baidoun F, Elshiwy K, Elkeraie Y, Merjaneh Z, Khoudari G, Sarmini MT, et al. Colorectal Cancer Epidemiology: Recent Trends and Impact on Outcomes. Curr Drug Targets. 2021;22(9):998-1009. doi: https://doi.org/10.2174/1389450121999201117115717

Trewin-Nybråten CB, Larsen IK, Møller B, Heikkilä R. Hospital surgical volume and colorectal cancer survival in Norway: A nationwide cohort study. Cancer epidemiol. 2023;85:102404. doi: https://doi.org/10.1016/j.canep.2023.102404

Published

2024-04-22

How to Cite

1.
Kubrak MA, Zavhorodnii SM, Danyliuk MB. Results of patient survival after surgical interventions for complicated forms of colon cancer performed in general surgical hospitals. Pathologia [Internet]. 2024Apr.22 [cited 2024Jul.18];21(1):61-5. Available from: http://pat.zsmu.edu.ua/article/view/300184

Issue

Section

Original research