Peculiarities of hemostasis changes under the influence of different regimens of antiplatelet therapy in patients with Q-wave myocardial infarction

Authors

DOI:

https://doi.org/10.14739/2310-1237.2014.3.36635

Keywords:

Myocardial Infarction, Protein C, von Willebrand Factor, Adhesion Molecules

Abstract

Aim. In order to study the influence of different regimens of antiplatelet therapy on the state of coagulation and aggregation hemostasis, intracardiac hemodynamics, incidence of post-infarction aneurysm and thrombus formation in the left ventricular cavity in patients with Q-wave myocardial infarction after thrombolysis, 123 people were examined.

Methods and results. All participants underwent echocardiography, the study of coagulation and aggregation hemostasis, levels of protein C, von Willebrand factor and adhesion molecules sVCAM-1 were determined.

Conclusion. Under the influence of the treatment reduction in aggregation and procoagulant activity of blood serum and activation of fibrinolytic processes were revealed, accompanied by improvement of left ventricular pumping and systolic function, diastolic dysfunction transformation from impaired relaxation into pseudonormal type.

References

Grinstein, Y. I., Savchenko, E. A., Filonenko, I. V., Grinstein, I. Yu., Savchenko, A. A. (2008). Zilt u pacientov s aterosklerozom koronarnykh arterij posle aortokoronarnogo shuntirovaniya. Predvaritelnye rezultaty otkrytogo, randomizirovannogo, sravnitelnogo issledovaniya ZEVS [Zyllt in coronary atherosclerosis patients after coronary artery bypass graft surgery. Preliminary results of an open, randomized, comparative ZEUS Study]. Kardiovaskulyarnaya terapiya i profilaktika, 7(6), 43–49. [in Russian].

Dzyak, G. V., Koval`, E. A., Ivanov, A. P., & Shevcova, A. I. (2007). Tip degradacii fibronektina kak novyj dopolnitelnyj faktor riska tromboticheskikh i gemorragicheskikkh oslozhnenij ostrogo infarkta miokarda s zubcom Q [Fibronectin degradation type as new additional risk factor of thrombotic and hemorrhagic complications of acute Q-wave myocardial infarction]. Sertse i sudyny, 1(17), 13–18. [in Ukrainian].

Kovalenko, V. M., & Kornatskyj, V. M. (Eds). (2013) Regionalni medyko-socialni problemy khvorob systemy krovoobihu. Dynamika ta analiz. Analityko-statystychnnyi posibnyk [Regional medical and social problems of cardiovascular system diseases. Dynamics and analysis. Analytic statistic textbook]. Kyiv. [in Ukrainian].

Syvolap, V. D., & Kyselov, S. M. (2014) Sostoyanie sistemy gemostaza i remodelirovanie serdca u bolnych Q-infarktom miokarda s ostroj anevrizmoj i pristenochnym trombom levogo zheludochka [Hemostatic system condition and heart remodeling in patients with Q-wave myocardial infarction with acute aneurysm and thrombus of left ventricle]. Zaporozhskij medicinskij zhurnal, 1(82), 48–51. [in Ukrainian].

(2013). ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction 2013. A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation, 127, e362-e425. doi: 10.1161/CIR.0b013e3182742cf6.

(2005). COMMIT collaborative group. Addition of clopidogrel to aspirin in 45852 patients with acute myocardial infarction: randomized placebo-controlled trial. Lancet, 366, 1607–1621. doi:10.1016/S0140-6736(05)67660-X.

Halvorsen, S., & Huber, K. (2010) The role of fibrinolysis in the era of primary percutaneous coronary intervention. Thromb. Haemost., 105, 390 – 395. doi: 10.1160/TH10-08-0513.

Sabatine, M. S., Cannon, C. P., Gibson, C. M., López-Sendón, J. L., Montalescot, G., Theroux, P., et al. (2005) Addition of clopidogrel to aspirin and fibrinolytic therapy for myocardial infarction with ST-segment elevation. N Engl J Med, 352, 1179–1189. doi: 10.1056/NEJMoa050522.

Scirica, B. M., Sabatine, M. S., Morrow, D. A., Gibson, C. M., Murphy, S., Wiviott, A. S. D., et al. (2006). The role of clopidogrel in early and sustained arterial patency after fibrinolysis for ST-segment elevation myocardial infarction. The ECG CLARITY-TIMI 28 study. J. Am. Coll. Cardiol., 48, 1, 37–42. doi:10.1016/j.jacc.2006.02.052.

How to Cite

1.
Kyselov SM. Peculiarities of hemostasis changes under the influence of different regimens of antiplatelet therapy in patients with Q-wave myocardial infarction. Pathologia [Internet]. 2014Dec.23 [cited 2024Dec.25];(3). Available from: http://pat.zsmu.edu.ua/article/view/36635

Issue

Section

Original research