Comparative characteristic of methods for determining the inflammation marker matrix metalloproteinase-9

Authors

  • E. V. Baranova
  • A. V. Abramov
  • V. I. Dariy

DOI:

https://doi.org/10.14739/2310-1237.2014.3.37048

Keywords:

Stroke, Matrix Metalloproteinase-9

Abstract

Aim. We examined 88 patients with stroke, for whom the determination of the concentration of matrix metalloproteinase-9 (MMP-9) in serum was carried out by standard methods declared in instructions supplied with the reagents kit, and by the modified methods.

Results.  It was determined that the modified methods of determining the MMP-9 can be used in predicting the occurrence of secondary hemorrhagic complications and to determine the feasibility and safety of thrombolytic therapy.

Conclusion. If the concentration of MMP-9 by the modified methods of determining is below 39,7 ng/ml, the percentage of secondary hemorrhagic complications is minimal.

References

Dziak, L. A., & Tsurkalenko, E. S. (2009). Insul't u molodykh pacientov [Stroke in young patients]. Zdorovia Ukrainy, 5/1, 12–15. [in Ukrainian].

Zozulia, Yu. P., Voloshyn, P. V., Mishchenko, T. S., & Dziak, L. A. (2005). Suchasni pryntsypy diagnostyky ta likuvannia khorykh iz hostrymy porushenniamy mozkovoho krovoobihu [Modern principles of diagnosis and treatment of patients with acute cerebrovascular circulation]. Kyiv. [in Ukrainian].

Suslina, Z. A., Varakin, Yu. A., & Vereshchahin, N. V. (2006). Sosudistye zabolevaniya golovnogo mozga [Vascular diseases of the brain]. E`pidemiologia. Osnovy profilaktiki. Moscow. [in Russian].

Khobzej, N. K., Golik, V. A., Gondulenko, N. A., Mishchenko, T. S. (2011). Osobennosti e`pidemiologii invalidnosti pri zabolevaniyakh nervnoj sistemy v Ukraine [Features of the epidemiology of disability in diseases of the nervous system in Ukraine]. Mizhnarodnyi nevrolohichnyi zhurnal, 5 (43), 13–16. [in Ukrainian].

Shamalov, N. A., Khasanova, D. R., Voznyuk, I. A., et al. (2007). Tromboliticheskaya terapiya pri ishemicheskom insul'te: opyt rossijskikh nevrologov. Po itogam II Rossijskogo mezhdunarodnogo kongressa «Cerebrovaskulyarnaya patologiya i insul't» [Thrombolytic therapy for ischemic stroke: the experience of Russian neurologists. According to the results of the II Russian international congress «Cerebrovascular pathology and stroke»] Zdorovia Ukrainy, 23/1, 10–13. [in Ukrainian].

Ahmed, N., Wahlgren, N., Grond, M., Hennerici, M., Lees, K. R., Mikulik, R., et al. (2010). Implementation and outcome of thrombolysis with alteplase 3–4,5 h after an acute stroke: an updated analysis from SITS-ISTR. Lancet. Neurology, 9, 866–874. doi: 10.1016/S1474-4422(10)70165-4.

Castellanos, M., Leira, R., Serena, J., Pumar, J. M., Lizasoain, I., Castillo, J., & Dávalos, A. (2003). Plasma metalloproteinase-9 concentration predicts hemorrhagic transformation in acute ischemic stroke. Stroke, 34, 40–46.

Hacke, W., Kaste, M., Bluhmki, E., Brozman, M., Dávalos, A., Guidetti, D., et al. (2008). Thrombolysis with Alteplase 3 to 4.5 hours after acute ischemic stroke. The New England Journal of Medicine, 359(13), 1317–1329. doi: 10.1056/NEJMoa0804656.

Jauch, E., Saver, J. L., Adams, H. P., Bruno, A., Connors, J. J., Demaerschalk, B. M., et al. (2013). Guidelines for the Early Management of Patients With Acute Ischemic Stroke A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke, 44, 870–947. doi: 10.1161/STR.0b013e318284056a.

Lloyd-Jones, D., Adams, R. J., Brown, T.M., Carnethon, M., Dai, S., De Simone, G., et al. (2010). Heart disease and stroke statistics – 2010 update: a report from the American Heart Association. Circulation, 121, e46–215. doi: 10.1161/CIRCULATIONAHA.109.19266.

Silva, G., & Furie, K. (2009). Biomarkers in neurology. Front. Neurol. Neurosci, 25, 55–61.

Thom, T., Haase, N., Rosamond, W., et al. (2006). Heart disease and stroke statistics – 2006 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation, 113, 85–151. doi: 10.1161/CIRCULATIONAHA.105.171600.

Downloads

How to Cite

1.
Baranova EV, Abramov AV, Dariy VI. Comparative characteristic of methods for determining the inflammation marker matrix metalloproteinase-9. Pathologia [Internet]. 2014Dec.23 [cited 2024Apr.25];(3). Available from: http://pat.zsmu.edu.ua/article/view/37048

Issue

No. 3 (2014)

Section

Original research

License

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
Лицензия Creative Commons
    1. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

  1. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (SeeThe Effect of Open Access).