Nuclear factor of activated T-cells (NFATC) as a possible diagnostic and prognostic marker in congenital valvular diseases and myocardial hypertrophy
DOI:
https://doi.org/10.14739/2310-1237.2015.1.42815Keywords:
Сongenital Heart Defects, Left Ventricular Hypertrophy, Genetic Polymorphism, NFATC Transcription FactorsAbstract
Aim. The nuclear factor of activated T-cells (NFATc 1-4) family gene expression against the background of cardiovascular disorders, accompanying both congenital heart diseases (mainly ones involving valvular defects) and arterial hypertension, is adaptive and stress-induced by the respective hemodynamic stress.
Results. In this regard, given the fact that these proteins play a critical role in both formation of the cardiac structures and, at the same time, development of pathological myocardial and vascular wall hypertrophy, they, along with the signaling activating factors, can be regarded as quite promising biological markers for early clinical prediction of development of the cardiovascular disorders in patients with certain congenital heart diseases (especially with valve anomalies) or hypertension.
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