Dynamics of pathological changes of myocardial structures of rats under administration of doxorubicin

Authors

  • А. G. Rodinskij
  • Ju. V. Kozlova
  • L. V. Guz'

DOI:

https://doi.org/10.14739/2310-1237.2015.1.42816

Keywords:

Doxorubicin, Myocardium, Rats

Abstract

Due to the high cardiotoxicity of doxorubicin it is used to study pathogenesis of heart failure.

Aim. In order to study the dynamics of pathological changes of the heart in the experiment, ECG, pathological and histopathological changes in the myocardium were investigated in 60 rats with doxorubicin cardiomyopathy and 60 rats in the control group.

Methods and results. We found that irreversible myocardial damage, established by us in the dynamics, namely destructive and degenerative changes of cardiomyocytes with the loss of their special characteristics, as a result of doxorubicin effect are not only local, but also diffuse, markers of which are the violation of the functional aspect of automaticity, conduction of the heart and rapidly progressive heart failure.

References

Chekman, I. S., Gorchakova, N. O., Nizhenkivs'ka, I. V., Nagorna, O. O., Mincer, V. O., Trofimova, T. S., & Vygivs'ka, O. A. (2003) Vplyv rubomitsynu hidrokhlorydu na pokaznyky hemodynamiky u kroliv [Effect of rubomicin hydrochloride on hemodynamic parameters in rabbits]. Medicine, 5–6, 88–89. [in Ukrainian].

Stefanov, A. V. (Ed) (2002) Doklinicheskie issledovaniya lekarstvennykh sredstv [Preclinical studies of drugs]. Kyiv: Avicenna. [in Ukrainian].

Kalinkina, N. V. (2000) Povrezhdeniya serdca antraciklinami: chastota i faktory riska [Damage to the heart anthracyclines: incidence and risk factors]. Ukrainskyi medychnyi chasopys, 16(2), 25–29. [in Ukrainian].

Korzhevskij, D. E`., & Gilyarov, A. V. (2010) Osnovy gistologicheskoj tekhniki [Fundamentals of histological techniques]. Saint Petersburg: SpecLit. [in Russian].

Matyash, M. G., Kravchuk, T. L., Vysotskaya, V. V., Chernov, V. I., Goldberg, V. E. (2008) Inducirovannaya antraciklinami kardiotoksichnost': mekhanizmy razvitiya i klinicheskie proyavleniya [Anthracycline-induced cardiotoxicity: mechanisms of development and clinical manifestations]. Sibirskij onkologicheskij zhurnal, 30(6), 66–75. [in Russian].

Lapach, S. N., Chubenko, A. V., Babich, P. N. (2001) Statisticheskie metody v mediko-biologicheskikh issledovaniyakh s ispol'zovaniem Excel [Statistical methods in biomedical research using Excel]. Kyiv: Morion. [in Ukrainian].

Rodynskyi, O. G., & Kozlova, Yu. V. (2014) Povedinkovi rozlady u shchuriv na foni eksperymentalnoi khronichnoi miokardialnoi dysfunktsii [Behavioral disorders in rats on a background of chronic experimental myocardial dysfunction]. Medychni perspektyvy, 19(3), 10–14. [in Ukrainian].

Semenova, A. I. (2009) Kardio- i nejrotoksichnost' protivoopukholevykh preparatov (patogenez, klinika, profilaktika, lechenie) [Cardio- and neurotoxicity of anticancer drugs (pathogenesis, clinical, prevention, treatment)]. Prakticheskaya onkologiya, 10(3), 168–176. [in Russian].

Cove-Smith, L., Woodhouse, N., Hargreaves, A., Kirk, J., Smith, S., Price, S. A., et al. (2014) An integrated characterization of serological, pathological, and functional events in doxorubicin-induced cardiotoxicity. Toxicol Sci., 140(1), 3–15. doi: 10.1093/toxsci/kfu057.

Kumar, S. N., Konorev, E. A., Aggarwal, D. & Kalyanaraman, B. (2011) Analysis of proteome changes in doxorubicin-treated adult rat cardiomyocyte. J. Proteomics, 74 (5), 683–697. doi: 10.1016/j.jprot.2011.02.013.

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How to Cite

1.
Rodinskij АG, Kozlova JV, Guz’ LV. Dynamics of pathological changes of myocardial structures of rats under administration of doxorubicin. Pathologia [Internet]. 2015May19 [cited 2024Dec.25];(1). Available from: http://pat.zsmu.edu.ua/article/view/42816

Issue

No. 1 (2015)

Section

Original research

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