Specific cell’s nuclei DNA content and cellular heterogeneity of colon adenocarcinoma
DOI:
https://doi.org/10.14739/2310-1237.2015.1.42878Keywords:
Large Intestine, Adenocarcinoma, DNA, Genetic HeterogeneityAbstract
Definition of properties and fine pathogenesis mechanisms is a direct condition for improving the effectiveness of the fight against cancer, including colon cancer.
Aim. In order to assess the cellular composition heterogeneity of colon adenocarcinoma (AC) on the specific DNA content in the cells’ nuclei 141 biopsies were studied using histological, histochemical, morphological, densitometric and mathematical methods.
Methods and results. It was established that in AC with grade increase (G) there is an increase in the relative proportion of cells with nuclei which are most appropriate for functional activity and vice versa.
Conclusion. This suggests that AC cellular heterogeneity is not linear, and the function approximates to the parabolic one.
References
Avtandilov, G. G. (2006). Diagnosticheskaya medicinskaya ploidometriya [Diagnostic medical ploidometry]. Moscow: Medicina. [in Russian].
Hrabovyi, O.M., Antoniuk, S. A, Vorobiei, Ye. A. (2013). Vmist nukleinovykh kyslot u yadrakh klityn epitelialnykh pukhlyn tovstoi kyshky [Nucleic acids contents in the colon epithelial tumor cells nuclei]. Ukrainskyi morfolohichnyi almanakh, 11(1), 73–76. [in Ukrainian].
Luppa, Kh. (1980) Osnovy khistokhimii [Basic histochemistry]. Moscow: Myr. [in Russian].
Tashke, K. (1980). Vvedenie v kolichestvennuyu cito-gistologicheskuyu morfologiyu. [Introduction to quantitative cyto-histological morphology]. Moscow. [in Russian].
Davoli, T., & de Lange, T. (2011). The Causes and Consequences of Polyploidy in Normal Development and Cancer. Ann. Rev. Cell Dev. Biol., 27, 585–610. doi: 10.1146/annurev-cellbio-092910-154234.
Greaves, M., & Maley, C. C. (2012) Clonal evolution in cancer. Nature, 481(7381), 306–313. doi: 10.1038/nature10762.
Holland, A., & Cleveland, D. (2012) Losing balance: the origin and impact of aneuploidy in cancer. EMBO, 13, 501–514. doi: 10.1038/embor.2012.55.
Melo, F. D. S. E., Vermeulen, L., Fessler, E., & Medema, J. P. (2013) Cancer heterogeneity – a multifaceted view. EMBO, 14(8), 686–695. doi: 10.1038/embor.2013.92.
Park, S., Choi, E., Jang, Y., Hong, S. H., Kim, I. H., & Chang, D. K. (2011). Effects of Chromosomal Polyploidy on Survival of Colon Cancer Cells. Korean J. Gastroenterol., 57(3), 150–157. doi: 10.4166/2011.57.3.150.
Visvader, J. E. (2011) Cells of origin in cancer. Nature, 469(7330), 314–322. doi: 10.1038/nature09781.
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