Manifestations of experimental hypothyroidism during the influence of moderate physical activity

Authors

  • M. R. Gerasymchuk

DOI:

https://doi.org/10.14739/2310-1237.2015.1.42933

Keywords:

Hypothyroidism, Exercise, Endotoxemia

Abstract

Hypothyroidism (HP) is accompanied by disturbances of hormonal homeostasis, decreased motor activity, increased body mass and, consequently, changes in the quality of life.

Aim. To study the effect of moderate physical activity (MPA) on experimental manifestations of HP.

Methods and results. 74 female Wistar rats were assessed for the changes in body weight (BW) and the state of endogenous intoxication (EI) by determining the average of middle molecular weight peptides (MMWP) and lactate (LT). It was found in animals with hypothyroidism, that BW increased by more than 25% (p<0,05), MMWP level in the blood increased by 19,44% (p<0,05), as well as in the major organs of detoxification  (liver and lungs) by 16,63% and 39,71% respectively, while LT – 6,8 times. In case of experimental HP combined with MPA, elevation of endotoxemia was slower and at a much lower level.

Conclusions. This indicates that in case of hypothyroidism, the state of EI is developed due to the intensification of the processes of formation of MMWP and LT. MPA proved to have a positive effect, resulting in the decrease of symptoms expressing HP.

References

Voronych-Semchenko, N. M. (2007) Biokhimichni pokaznyky syrovatky krovi shchuriv z hipotyreozom v umovakh korektsii preparatom yodyd-100 [Biochemical parameters of blood serum of rats with hypothyroidism in terms of correcting by Iodide-100 drug]. Fiziolohichnyy zhurnal, 53(6), 9–13. [in Ukrainian].

Katerenchuk, B. I. & Katerenchuk, I. P. (2012) Sertsevo-sudynna patolohiia, zumovlena hipotyreozom [Cardiovascular disease agreed hypothyroidism]. Endokrynolohiia, 17(1), 106–112. [in Ukrainian].

Petrulea, M. S., Duncea, I., Hazil, G., Dragotoiu, G., Decea, N., & Mureşan, A. (2010) Oxidative stress in experimental hypothyroidism: effect of vitamin E supplementation. Clujul Medical, LXXXIII (2), 245–249.

Popadynets, O. H., & Ersteniuk, A. M.( 2012) Vzaiemozviazok strukturnykh zmin u stintsi sechovoho mikhura pid vplyvom riznomanitnykh faktoriv iz biokhimichnymy protsesamy [Relationship structural changes in the bladder wall under the influence of various factors of biochemical processes]. Arkhiv klinichnoi medytsyny, 18, 72–77. [in Ukrainian].

Gerasymchuk, M. R., & Zaiats, L. M. (2012) Novi pogliady na otsinku hostroho lehenevoho ushkodzhennia na foni eksperymentalnoho perytonitu [New views on the assessment of acute lung injury in experimental peritonitis]. Tavricheskij mediko-biologicheskij vestnik, 15(3)/1(59), 63–68. [in Ukrainian].

Gerasymchuk, M. R., Kishchuk, B. M., Zayats, L. M., & Cherkasova, V. V. (2013) Role of endogenous intoxication in the lung injury development during experimental diabetes mellitus. Klinichna farmatsiia, 17(4), 48–51. [in Ukrainian].

Pobihun, N. H. (2014) Doslidzhennia zmin pokaznykiv kaltsiievoho metabolizmu v shchuriv zi znyzhenoiu funktsiieiu shchytopodibnoi zalozy pid vplyvom fizychnoho navantazhennia [The investigation of changes of indexes of calcium metabolism in rats with decreased function of thyroid gland under the influence of physical loading]. Bukovynskyi medychnyi visnyk, 18, 3(71) 119–123. [in Ukrainian].

Kvolik, S., Drenjančević-Perić, I., & Takač, I. (2009) Microcirculation impairment and blood pressure in sepsis. Medicinski Glasnik, 6(1), 32–41.

Chechet, O., Badger, A. L., & Kuzin, V. B. (2010) Effect on the peroxide oxidation of proteins of new derivates of the 3-hydroxypyridine. STM, 22–25.

How to Cite

1.
Gerasymchuk MR. Manifestations of experimental hypothyroidism during the influence of moderate physical activity. Pathologia [Internet]. 2015May19 [cited 2024Nov.2];(1). Available from: http://pat.zsmu.edu.ua/article/view/42933

Issue

Section

Original research