Analysis of methodological approaches for simulation of gestational antiphospholipid syndrome
DOI:
https://doi.org/10.14739/2310-1237.2015.2.48617Keywords:
antiphospholipid syndrome, experimental model, pregnancyAbstract
Experimental study of obstetric antiphospholipid syndrome may reduce morbidity and deaths of women and newborns.
Aim. The aim of the work is to examine relevant literature on modeling obstetric antiphospholipid syndrome, to choose the most appropriate model and to reproduce it in accordance with existing clinical criteria. The current views on the modeling of disease depending on the purposes, selection of laboratory animals, treatment and dosing medications, evaluation of the effectiveness of simulation and experimental treatment were comprehensively analyzed.
Results. According to the authors the most appropriate model is a model of active immunization of mice with the cardiolipin antigen, which was reproduced in the author's modification.
References
Kathy, D. (Ed.) (1991). Antitela. Metody [Antibodies. Methods]. Moskow: Mir. [in Russian].
Stefanov, O. V. (Ed.) (2001) Doklinichni doslidzhennia likarskykh zasobiv [Preclinical studies of drugs]. Kyiv: Avicena. [in Ukrainian].
Zapadnyuk, I. P., Zapadnyuk, V. I., Zakhariya, E. A. (1974) Laboratornye zhivotnye. Razvedenie soderzhanie i ispol'zovanie v e`ksperimente [Laboratory animals. Breeding content and use in the experiment]. Kyiv: Vyshcha shkola. [in Ukrainian].
Makacariya, A. D. (2001) Antifosfolipidnyj sindrom v akusherskoj praktike [Antiphospholipid syndrome in obstetric practice]. Moscow: Russo. [in Russian].
Medvedev, M. V. (2006) Prohnozuvannia ta profilaktyka platsentarnoi nedostatnosti u vahitnykh z antyfosfolipidnym syndromom, pov’iazanym z urohenitalnoiu infektsiieiu (Avtoref. dis…kand. med. nauk). [Prediction and prevention of placental insufficiency in pregnant women with antiphospholipid syndrome, associated with urogenital infections]. (Extended abstract of candidate’s thesis). Kyiv [in Ukrainian].
Nakaz Ministerstva okhorony zdorovia Ukrainy Pro zatverdzhennia klinichnykh protokoliv nadannia medychnoi dopomohy khvorym z imunnymy zakhvoriuvanniamy 8 zhontnia 2007 roku № 626 [Order of the Ministry of Health of Ukraine On approval of clinical protocols of care for patients with immune diseases from October 8 2007 №626] Retrieved from http://moz.gov.ua/ua/main/docs/?docID=8760. [in Ukrainian].
Nasonov, E. L. (2004) Antifosfolipidnyj sindrom [Antiphospholipid syndrome]. Moscow: Litterra. [in Russian].
Prokopiuk, V. Yu., Prokopiuk, O. S., Trifonov, V. Yu., et al. (patentee) (2011) Patent Ukrainy №62029. Ukraina. G09B. Sposib modeliuvannia akusherskoho antyfosfolipidnoho syndrome [Ukrainian. MPK G09V. Method simulation obstetric antiphospholipid syndrome]. Biuleten, 15. [in Ukrainian].
Prokopiuk, V. Yu. (2011) E`ksperimental'naya ocenka e`ffektivnosti pregravidarnoj podgotovki i lecheniya antifosfolipidnogo sindroma [Experimental evaluation of the effectiveness of training and pregravidal treatment of antiphospholipid syndrome]. Klіnіchna ta eksperymentalna patolohіia, 2(36), 79–82. [in Ukrainian].
Rybalov, Yu. R., & Rybalov, R. S. (1979) Dozirovanie veschestv dlya mlekopitayuschikh po kontrolyu biologicheskoj aktivnosti [Dosing substances for mammals to control biological activity]. ADANSSSR, 247(6), 1513–1516. [in Russian].
Trifonov, V. Yu., & Prokopiuk, V. Yu. (2010) Sovremennye predstavleniya ob akusherskom antifosfolipidnom sindrome [Current concepts of obstetric antiphospholipid syndrome]. Eksperymentalna i klіnіchna medytsyna, 2, 50–55. [in Ukrainian].
Trifonov, V. Yu., Prokopyuk, V. Yu., Prokopyuk, O. S., Lipina, O. V., Volina, V. V., Zub, L. I., et al. (2010) E`ksperimental'noe obosnovanie vozmozhnosti pregravidarnoj profilaktiki antifosfolipidnogo sindroma [Experimental study the possibility of preventing pregravidal antiphospholipid syndrome]. Tavricheskij mediko-biologicheskij vestnik, 4(52), 188–192. [in Ukrainian].
Backos, M., Rai, R., Baxter, N., Chilcott, I. T., Cohen, H., & Regan, L. (1999) Pregnancy complications in women with recurrent miscarriage associated with antiphospholipid antibodies treated with low dose aspirin and heparin. Br J Obstet Gynaecol, 106(2), 102–107.
Di Simone, N., Di Nicuolo, F., D'Ippolito, S., Castellan,i R., Tersigni, C., Caruso, A., et al. (2010) Antiphospholipid antibodies affect human endometrial angiogenesis. Biol Reprod, 83(2), 212–219. doi: 10.1095/biolreprod.110.083410.
Francis, J., Rai, R., Sebire, N. J. El-Gaddal, S., Fernandes, M. S., Jindal, P., et al. (2006) Impaired expression of endometrial differentiation markers and complement regulatory proteins in patients with recurrent pregnancy loss associated with antiphospholipid syndrome. Hum Reprod, 12(7), 435–442. doi: 10.1093/molehr/gal048.
Furukawa S., Kuroda Y., & Sugiyama A. A (2014) Comparison of the Histological Structure of the Placenta in Experimental Animals. J Toxicol Pathol, 27(1), 11–18. doi: 10.1293/tox.2013-0060.
Lim, W. (2013) Antiphospholipid syndrome. Hematology Am Soc Hematol Educ Program, 2013, 675–680.
Lockshin, M. D. (2013) Anticoagulation in management of antiphospholipid antibody syndrome in pregnancy. Clin Lab Med, 33(2), 367–376. doi: 10.1016/j.cll.2013.01.001.
Lockshin, M. D. (2013) Pregnancy and antiphospholipid syndrome. Am J Reprod Immunol, 69(6), 585–758.
Marchetti, T., Cohen, M., & de Moerloose, P. (2013) Obstetrical antiphospholipid syndrome: from the pathogenesis to the clinical and therapeutic implications. Clin Dev Immunol, 2013, 1–9. doi.org/10.1155/2013/159124.
Pierangeli, S. S., Chen, P. P., Raschi, E., Scurati, S., Grossi, C., Borghi, M.O., et al. (2008) Antiphospholipid antibodies and the antiphospholipid syndrome: pathogenic mechanisms. Semin Thromb Hemost, 34(3), 236–250. doi: 10.1055/s-0028-1082267.
Radway-Bright, E. L., Inanc, M., & Isenberg, D. A. (1999) Animal models of the antiphospholipid syndrome. Reumatology (Oxford), 38(7), 591–601.
Salmon, J. E., & Girardi, G. (2008) Antiphospholipid antibodies and pregnancy loss: a disorder of inflammation. J Reprod Immunol, 77(1), 51–56. doi:10.1016/j.jri.2007.02.007.
Shanmugan, V., Govindaraju, A., & Kumbalingam, B. (2007) Placental Thrombosis in Experimental Anticardiolipin Antibodies-Mediated Intrauterine Fetal Death. American Journal of Reproductive Immunology, 57(4), 270–276. doi: 10.1111/j.1600-0897.2007.00474.x
Shoenfeld, Y., & Ziporen, L. (1998) Lessons from experimental APS models. Lupus, 7, 158–161.
Tincani, A., Spalota, L., Cinquini, M. Meroni, P., Balestrieri, G., & Shoenfeld, Y. (1998) Animal models of antiphospholipid syndrome Rev. Rheum. Engl. Ed, 65(11), 614–618.
Tong, M., Viall, C. A., & Chamley, L. W. (2015) Antiphospholipid antibodies and the placenta: a systematic review of their in vitro effects and modulation by treatment Hum. Reprod. Update, 21(1), 97–118. doi: 10.1093/humupd/dmu049.
Vega-Ostertag, M. E., & Pierangeli, S. S. (2007) Mechanisms of aPL-mediated thrombosis: effects of aPL on endothelium and platelets Curr. Rheumatol. Rep., 9(3), 190–197.
Viall, C. A., & Chamley, L. W. (2015) Histopathology in the placentae of women with antiphospholipid antibodies: A systematic review of the literature. Autoimmun. Rev., [Epub ahead of print].
Downloads
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (SeeThe Effect of Open Access).
