The pathomorphology features of kidneys lesion in the metabolic syndrome (evidences of autopsy and experiment)
DOI:
https://doi.org/10.14739/2310-1237.2015.2.50872Keywords:
Kidney Disease, Metabolic DiseasesAbstract
The global increase in the number of people with chronic kidney disease requires new approaches to their prevention and treatment.
Aim: To investigate the pathomorphology features of kidneys lesion in the metabolic syndrome (evidences of autopsy and experiment)
Methods and results. The pathomorphology features of kidneys lesion on autopsy of kidneys of 124 deceased patients with the metabolic syndrome and in 40 experimental animals (rats) were identified by light and electron microscopy method. All the changes of kidney, which we observed, were typical for common conditions – diabetes mellitus type 2, hypertension, obesity and dyslipidemia. We established that the damage of kidney's components was characterized by heterogeneity and heterochronicity.
Conclusion. The pathomorphology features were characterized by dystrophy in smooth muscle cells of arterioles, thickening of the basement membrane, mesangium proliferation, hyalinosis and focal-segmental sclerosis.
References
Hall, M. E., do Carmo, J. M., da Silva, A.A., Juncos, L. A., Wang, Z., & Hall, J. E. (2014). Obesity, hypertension, and chronic kidney disease. Int. J. Nephrol. Renovasc. Dis., 7, 75–88. doi: 10.2147/IJNRD.S39739.
Foster, M. C., Hwang, S. J., Porter, S. A., Massaro, J. M,. Hoffmann, U., & Fox, C.S. (2011). Fatty kidney, hypertension, and chronic kidney disease: the Framingham Heart Study. Hypertension, 58(5), 784–790. doi: 10.1161/HYPERTENSIONAHA.111.175315.
Vallon, V., & Komers, R. (2011). Pathophysiology of the diabetic kidney. Compr. Physiol.,1(3), 1175–1232. doi: 10.1002/cphy.c100049.
Singh, A. K., & Kari, J. A. (2013). Metabolic syndrome and chronic kidney disease. Curr. Opin. Nephrol. Hypertens., 22(2), 198–203. doi: 10.1097/MNH.0b013e32835dda78.
Glubaa, A., Mikhailidisb, D. P., Lip, G. Y., Hannamd, S., Rysza, J., & Banache, M. (2013). Metabolic syndrome and renal disease. Int. J. Cardiol., 164, 141–150. doi:10.1016/j.ijcard.2012.01.013.
Tonolo, G., & Cherchi, S. (2014). Tubulointerstitial disease in diabetic nephropathy. Int. J. Nephrol. Renovasc. Dis., 7, 107–115. doi:http://dx.doi.org/10.2147/IJNRD.S37883.
Pan, S. Y., Chang, Y. T., & Lin, S. L. (2014). Microvascular pericytes in healthy and diseased kidneys. Int. J. Nephrol. Renovasc. Dis., 7, 39–48. doi: 10.2147/IJNRD.S37892.
Eddy, A. A., López-Guisa, J. M., Okamura, D. M. & Yamaguchi, I. (2012). Investigating mechanisms of chronic kidney disease in mouse models. Pediatr. Nephrol., 27(8), 1233–1247. doi: 10.1007/s00467-011-1938-2.
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