The ultrastructure of hepatic endothelial cells in the correction of steatosis with new biologically active compound Angiolin

Authors

  • K. V. Pivtorak Vinnytsya National Medical University,
  • I. A. Mazur Zaporizhzhia State Medical University,
  • M. A. Voloshyn Zaporizhzhia State Medical University,

DOI:

https://doi.org/10.14739/2310-1237.2015.3.55587

Keywords:

Liver Diseases, Hepatocytes, Electron Microscopy

Abstract

Aim. To characterize the ultrastructural organization of endothelial cells, hepatocytes in correction of experimental hepatic steatosis with Angiolin.

Methods and results. Experimental studies were carried out on 70 adult white male rats. The model of liver steatosis was created in 60 rats, some of the animals (30 rats) were treated with Angiolin administration (50 mg per kg of body weight). The animals of control and experimental groups were examined for ultrastructural changes in hepatocytes and endothelial cells of liver hemomicrocirculatory bed vessels. Studies of the ultrastructure of the liver of animals have found that the normalization of the structural components of the organ took place in the correction of steatosis with new biologically active compound Angiolin. Normalization of sinusoidal hemocapillars ultrastructure improves hemodynamics and transcapillary exchange. This fact prevents damage to the hepatocyte nuclei and organelles, facilitates intracellular regeneration.

Conclusion. Using new biologically active compound Angiolin prevents and reduces the damage of membrane organelles, nuclear and plasma membranes of endothelial cells and hepatocytes.

References

Denysiuk, V. I., & Khrebtii, H. I. (2011) Endotelialna dysfunktsiia ta insulinorezistentnist u patsiientiv z arterialnoiu hipertenziieiu – «dvi storony odniiei medali» [Endothelial dysfunction and insulin resistance in patients with hypertension – «two sides of the same coin»]. Consilium Medicum Ukraina, 5, 3–5. [in Ukrainian].

Kolesnyk, Yu. M., Chekman, I. S., Mazur, I. A., Belenichev, I. F., Horchakova, N. O., & Nahorna, O. O. (2014) Mekhanismy rozvytku endotelialnoi dysfunktsii ta poshuk endotelioprotektoriv [Mechanisms of development of endothelial dysfunction and search for endothelioprotectors]. Zhurnal NAMN Ukrainy, 20(3), 289–299. [in Ukrainian].

Kolesnikova, E. V. (2014) Sovremennyi pacient s zabolevaniem pecheni i patologiej serdechno-sosudistoj sistemy: kakoj vybor sdelat′? [The modern patient with liver disease and pathology of cardiovascular system: what choice to make?]. Suchasna hastroenterolohіia, 2(76), 85–94. [in Ukrainian].

Pivtorak, K. V. (2015) Elektronno-mikroskopichni zminy pechinky pry eksperymentalnomu steatozi [Submicroscopic changes in experimental hepatic steatosis]. Vіsnyk morfolohіi, 21(1), 69–72. [in Ukrainian].

Pivtorak, K. V. (2015) Submikroskopichnyi stan pechinky pry korektsii steatozu hepatoprotektorom aminokyslotnoho pokhodzhennia [Submicroscopic State of the Liver in the Correction of Steatosis Using the Hepatoprotector of Amino Acid Origin]. Vіsnyk problem bіologіi i medytsyny, 3, 2(123), 310–313. [in Ukrainian].

Kharchenko, N. V., Anokhina, H. A., Kharchenko, V. V., Opanasiuk, N.D., Lopukh, I. Ya., & Korulia, I. A. (2011) Osoblyvosti likuvannia nealkoholnoho steatohepatytu u khvorykh na tsukrovyi diabet [Peculiarities of the treatment of non-alcoholic steatohepatitis in patients with diabetes mellitus]. Suchasna hastroenterolohіia, 2(58), 60–64. [in Ukrainian].

Belenichev, I. F., Mazur, I. A., & Bukhtiyarova, N. V. (2013) The endothelium-protective effect of 3-methyl-1,2,4-triazolyl-5-thioacrtate(S)-2,6-diaminohoexanic acid (Lysinium: Effects on the expression of vascular endothelial growth factor (VEGF) and the characteristics of the endotheliocytes of the cerebral vessels of animals with cerebral ischemia. Neurochem. J., 7(4), 296–303.

Fargion, S., Porzio, M., & Fracanzani, A. L. (2014) Nonalcoholic fatty liver disease and vascular disease: State-of-the-art. World J. Gastroenterol, 20(37), 13306–13324. doi: 10.3748/wjg.v20.i37.13306.

Kucera, O., & Cervinkova, Z. (2014) Experimental models of non-alcoholic fatty liver disease in rats. World J. Gastroenterol, 20(26), 8364–8376. doi: 10.3748/wjg.v20.i26.8364.

Downloads

How to Cite

1.
Pivtorak KV, Mazur IA, Voloshyn MA. The ultrastructure of hepatic endothelial cells in the correction of steatosis with new biologically active compound Angiolin. Pathologia [Internet]. 2015Dec.18 [cited 2024Dec.25];(3). Available from: http://pat.zsmu.edu.ua/article/view/55587

Issue

No. 3 (2015)

Section

Original research

License

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
Лицензия Creative Commons
    1. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

  1. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (SeeThe Effect of Open Access).