Interdependence of neurohumoral regulation indicators and state of the autonomic nervous system in patients with psoriasis according to gender

Authors

  • Abboud Aymen Zaporizhzhia State Medical University,

DOI:

https://doi.org/10.14739/2310-1237.2016.1.72238

Keywords:

Psoriasis, Autonomic Nervous System, Sex Factors

Abstract

Data on the importance of neurohumoral regulation violations in the etiology and pathogenesis of psoriasis necessitate the study of the nervous and endocrine systems depending on the gender of the patient. In order to study neurohumoral regulation in 65 psoriasis patients, 37 women and 28 men, the state of the autonomic nervous system and hormone levels – ACTH, cortisol and TTH were studied.

The study found that levels of ACTH and cortisol in all the women with psoriasis – vagotonics, normotonics, sympathotonics were significantly higher than the corresponding figures in men patients with psoriasis. In vagotonics group reliability of prevailing indices on the levels of ACTH, cortisol and TTH was observed. In sympathotonics the data is valid only concerning cortisol, in normotonics group – only ACTH level. In vagotonics men and women with psoriasis and normo- and sympathotonics women indicators of cortisol were higher than physiological parameters. In normotonics female patients with psoriasis cortisol indicators were significantly lower than relative level of cortisol in vagotonics women. In sympathotonics women cortisol level was lower relative to vagotonics and higher than in normotonics, significant data. ACTH and TTH level was higher than physiological parameters only in groups of women vagotonics patients. Thus, compensatory effects of cortisol are leveled with the dominance of parasympathetic tone and female dominant.

This indicates that the tension of regulatory mechanisms is associated with parasympathetic tone of the autonomic nervous system. Parasympathetic tone of the autonomic nervous system is to a greater extent vulnerable than compensatory. It should be noted that in vagotonics women steroid homeostasis is shifted towards corticoid activity that is an unfavorable factor of the female organism functioning.

References

Baevski, R. M., Kirillov, O. I., & Kleckin, S. Z. (1984) Matematicheskij analiz serdechnogo ritma pri stresse [Mathematical analysis of heart rate during stress]. Moscow: Nauka. [in Russian].

Dobrozhanska, Ye. I. (2008) Vyznachennia zmin vmistu adaptyvnykh hormoniv i systemy imennoho zakhystu u khvorykh na psoriaz [Determination of content changes hormones and adaptive immune defense system in patients with psoriasis]. Ukrainskyi zhurnal dermatolohii, venerolohii, kosmetolohii, 1, 9–11. [in Ukrainian].

Zagrtdinova, R. M., Filimonov, M. A., Ivanova, M. A., & Orlov, S. A. (2006) Sostoyanie gipofizarno-tireoidnoj sistemy u bol'nykh psoriazom [The pituitary-thyroid system in patients with psoriasis]. Rossijskij zhurnal kozhnykh i venericheskikh boleznej, 2, 20–24. [in Russian].

Kashutin, S. L., & Prelovskaya, I. B. (2009) Soderzhanie gormonov v sisteme gipofiz-kora nadpochechnikov i gipofiz-shhitovidnaya zheleza u bol'nykh s psoriazom [The content of hormones in the pituitary-adrenal cortex and pituitary-thyroid systems in patients with psoriasis]. Rossijskij zhurnal kozhnykh i venericheskikh boleznej, 1, 24–25. [in Russian].

Kuts, L. V. (2012) Suchasni aspekty «neirohennoho» komponentu zapalennia pry psoriazi [Modern aspects "neurogenic" component of inflammation in psoriasis]. Visnyk problem biolohii i medytsyny, 4(2), 96–98. [in Ukrainian].

Krueger, J. G., & Bowcock, A. (2005) Psoriasis pathophysiology: current concepts of pathogenesis. Ann Rheu at Dis., 64, 1130–1136. doi: 10.1136/ard.2004.031120.

Schon, M., & Boehncke, W. (2005) Psoriasis. N. Engl. J. Med., 352, 1899–1904.

Schmitt, J., & Ford, D. (2010) Psoriasis is independently associated with psychiatric morbidity and adverse cardiovascular risk factors, but not with cardiovascular events in a population-based sample. J. Eur. Acad. Dermatol. Venereol, 24, 885–892. doi: 10.1111/j.1468-3083.2009.03537.x.

How to Cite

1.
Aymen A. Interdependence of neurohumoral regulation indicators and state of the autonomic nervous system in patients with psoriasis according to gender. Pathologia [Internet]. 2016Jun.23 [cited 2024Oct.8];(1). Available from: http://pat.zsmu.edu.ua/article/view/72238

Issue

Section

Original research