Current methods of the modeling of experimental diabetes mellitus type 2: a literature review

Authors

  • Yu. M. Kolesnyk Zaporizhzhya State Medical University,
  • T. V. Ivanenko Zaporizhzhya State Medical University,
  • A. V. Abramov Zaporizhzhya State Medical University,
  • N. V. Kuzo Zaporizhzhya State Medical University,

DOI:

https://doi.org/10.14739/2310-1237.2016.1.72365

Keywords:

Diabetes Mellitus Type 2, Experimentation Animal, Rats, Insulin Resistance

Abstract

Background. Diabetes mellitus (DM) became a major problem of the healthcare in Ukraine. The rapid increase in the incidence was noticed especially in recent decade. The treatment of diabetes and its complications become a difficult task. From this standpoint the experimental modeling of diabetes is rather essential. Using the experimental models gives the possibility to assess the significance of the activity of pharmacological substances or to find out new mechanism in the action of medicaments.

The aim of this review is to light up the most studied and common experimental models of diabetes mellitus type 2 (T2DM) in small rodents and find out their drawbacks. It is known the background of T2DM is the violation of the insulin homeostasis such as the resistance of peripheral tissues to insulin as well as the dysfunction of the pancreatic beta-cells, which both lead to appearance of such phenomena as the glucosetoxicity and the lipotoxicity. In the end they both could result in life threatening vascular complications. Considering the steady growth of T2DM patients, the development both of the drug and non-drug methods of its treatment with the high therapeutically efficiency and the perfect safety profile becomes essential. The most important stage of the search of new ways of influence on pathogenetic links of T2DM is the preclinical stage. From this standpoint the usage of experimental models of T2DM has a huge importance. There are a lot of models of T2DM developed by different scientists. These models could be spontaneous or be induced by different chemical diabetogenic substances, diet or surgical interventions or be a combination of methods listed above.

Conclusions. We should underline the adequate modeling of DM2T is the necessary basis for the pre-clinical study of drug-based and not-drug methods of correction of the hyperglycemic states. Using different models makes it possible for infer the obtained experimental results to the society, which suffers from DM2T.

References

(2016). Ofitsiinyi sait Vsesvitnoi orhanizatsii okhorony zdorovia [World Health Organization]. Retrieved from http://www.who.int.

Srinivasan, K. & Ramarao, P. (2007). Animal models in type 2 diabetes research: an overview. Indian J Med Res, 125(3), 451–72.

Risbud, M. & Bhonde, R. (2003). Models of pancreatic regeneration in diabetes. Diabetes Research And Clinical Practice, 58(3), 155–165. doi: 10.1016/S0168-8227(02)00103-1.

Prochazka, M., Leiter, E., & Shultz, L. (1987). Effect of immunodeficiency on diabetogenesis in getenocally diabetic (db/db) mice. J. Immunol., 138, 149–154.

Islam, M. & Loots, D. (2009). Experimental rodent models of type 2 diabetes: A review. Methods And Findings In Experimental And Clinical Pharmacology, 31(4), 249. doi: 10.1358/mf.2009.31.4.1362513.

Spasov, A. A., Voronkova, M. P., Snigur, G. L., Gheplyaeva, N. I., & Chepurnova, M. V. (2011). Experimentalnaya model sacharnogo diabeta tipa 2 [Experimental model of diabetes mellitus type 2]. Biomedicina, 3, 12–18. [in Russian]

Portha, B. & Kergoat, M. (1985). Dynamics of glucose-induced insulin release during the spontaneous remission of streptozocin diabetes induced in the newborn rat. Diabetes, 34(6), 574–579. http://dx.doi.org/10.2337/diabetes.34.6.574.

Bobkiewicz-Kozłowska, T., Dworacka, M., Kuczyński, S., Abramczyk, M., Kolanoś, R., Wysocka, W. et al. (2007). Hypoglycaemic effect of quinolizidine alkaloids — lupanine and 2-thionosparteine on non-diabetic and streptozotocin-induced diabetic rats. European Journal Of Pharmacology, 565(1-3), 240–244.

Bonnevie-Nielsen, V., Steffes, M., & Lernmark, A. (1981). A major loss in islet mass and B-cell function precedes hyperglycemia in mice given multiple low doses of streptozotocin. Diabetes, 30(5), 424–429. http://dx.doi.org/10.2337/diabetes.30.5.424.

Novelli, M., Barbera, M., & Fierabracci, V. (1996). Effect of the age and dexamethasone treatment on insulin secretion from isolated perfused rat pancreas. Diabetol, 1, A124.

Buren, J. & Eriksson, J. (1999). Dexamethasone decreases GLUT 1 and GLUT 4 content in primary cultured rat adipocytes. Diabetol, 42(1), A170.

Fabregat, M., Fernandez-Alvarez, J., & Franco, C. (1999). Dexamethasone-induced changes in FAD-glycerophosphate dehydrogenase expression in human pancreas islets. Diabetol, 42(1), A141.

Tanaka, S., Hayashi, T., Toyoda, T., Hamada, T., Shimizu, Y., & Hirata, M. et al. (2007). High-fat diet impairs the effects of a single bout of endurance exercise on glucose transport and insulin sensitivity in rat skeletal muscle. Metabolism, 56(12), 1719–1728. doi:10.1016/j.metabol.2007.07.017.

Zhao, S., Chu, Y., Zhang, C., Lin, Y., Xu, K., Yang, P., et al. (2007). Diet-induced central obesity and insulin resistance in rabbits. Journal of Animal Physiology and Animal Nutrition, 92(1), 105–111. doi: 10.1111/j.1439-0396.2007.00723.x.

Flanagan, A., Brown, J., Santiago, C., Aad, P., Spicer, L., & Spicer, M. (2008). High-fat diets promote insulin resistance through cytokine gene expression in growing female rats. The Journal Of Nutritional Biochemistry, 19(8), 505–513. http://dx.doi.org/10.1016/j.jnutbio.2007.06.005.

Reed, M., Meszaros, K., Entes, L., Claypool, M., Pinkett, J., Gadbois, T., & Reaven, G. (2000). A new rat model of type 2 diabetes: The fat-fed, streptozotocin-treated rat. Metabolism, 49(11), 1390–1394. doi: 10.1053/meta.2000.17721.•

Srinivasan, K., Viswanad, B., Asrat, L., Kaul, C., & Ramarao, P. (2005). Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: A model for type 2 diabetes and pharmacological screening. Pharmacological Research, 52(4), 313–320.

Sahin, K., Onderci, M., Tuzcu, M., Ustundag, B., Cikim, G., Ozercan, İ., et al. (2007). Effect of chromium on carbohydrate and lipid metabolism in a rat model of type 2 diabetes mellitus: the fat-fed, streptozotocin-treated rat. Metabolism, 56(9), 1233–1240. doi: http://dx.doi.org/10.1016/j.metabol.2007.04.021.

Zhang, M., Lv, X., Li, J., Xu, Z., & Chen, L. (2008). The Characterization of High-Fat Diet and Multiple Low-Dose Streptozotocin Induced Type 2 Diabetes Rat Model. Experimental Diabetes Research, 2008, 1–9. doi: 10.1155/2008/704045. •

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1.
Kolesnyk YM, Ivanenko TV, Abramov AV, Kuzo NV. Current methods of the modeling of experimental diabetes mellitus type 2: a literature review. Pathologia [Internet]. 2016Jun.23 [cited 2024Nov.24];(1). Available from: http://pat.zsmu.edu.ua/article/view/72365

Issue

No. 1 (2016)

Section

Review

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