Мукозо-асоційована (MALT) лімфома шлунку: особливості патоморфологічної діагностики

V. О. Tumanskiy; I. S. Kovalenko

doi:10.14739/2310-1237.2012.1.15292

Authors

V. О. Tumanskiy
I. S. Kovalenko

DOI:

https://doi.org/10.14739/2310-1237.2012.1.15292

Keywords:

MALT-lymphoma of the stomach, pathomorphological diagnostics

Abstract

On the base of our own observations and literature data it was determined that the distinctive pathologic features of MALT-lymphoma of the stomach is tight diffuse lymphocytic infiltrate in the lamina propria between the reactive lymph follicles and glands of the mucous membrane by centrocyte-like tumor cells of marginal zone, monocytoid B-lymphocytes, small lymphocytes, plasma cells and a single large centroblasts-like or immunoblasts-like cells, the presence of zones "lymphoepithelial lesions" of glands due to infiltration by tumor cell aggregates, and Dutcher bodies in plasma cells. The main immunophenotypic feature of the MALT-lymphoma is the presence of diffuse immun cell infiltration by CD20+, IgM+, IGD-B-cells outside the reactive follicles mantle zone. Immunophenotype of tumor MALT-lymphoma cells is identical to the immunophenotype of marginal zone B-cells, the reaction with antibodies against CD5, CD10 and CD23 is negative. It was described molecular and genetic disorders, histologic evidence of lymphoma varying degrees of malignancy, stages of stomach MALT-lymphoma to select the method of patient’s treatment.

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