Рівень аутоантитіл до антигенів щитоподібної залози  при метаболічному синдромі на тлі дефіциту естрогенів та гіпотиреозу

V. V. Kozak

doi:10.14739/2310-1237.2012.2.16759

Authors

V. V. Kozak

DOI:

https://doi.org/10.14739/2310-1237.2012.2.16759

Keywords:

deficiency of estrogens, metabolic syndrome, hypothyroidism, autoantibodies, 17β-estradiol

Abstract

It has been shown that the concentration of autoantibodies to thyroperoxidase was significantly increased in rats with estrogen-deficiency. The combination of hypoestrogenia and metabolic syndrome with hypothyroidism intensified destructive processes in the thyroid gland. 17β-estradiol had the protective effect to the damaged thyroid gland in ovarioectomized animals with metabolic syndrome and hypothyroidism that was confirmed by significant reduction of concentration of autoantibodies to thyroperoxidase.

References

Bizzaro N. The predictive significance of autoantibodies in organ-specific autoimmune diseases / Bizzaro N.// Clin. Rev. Allergy Immunol. – 2008. – Vol. 34, №3. – P. 326–331.
Cappola A.R. Hypothyroidism and atherosclerosis / Cappola A.R., Ladenson P.W. // J. Clin. Endocrinol. Metab. – 2003.– Vol. 88, №6. – P. 2438–2444.
Duntas L.H. Cardiovascular risk and subclinical hypo-thyroidism: focus on lipids and new emerging risk factors. What is the evidence? / Duntas L.H., Wartofsky L. // Thyroid. – 2007. – Vol. 17, №11. – P. 1075–1084.
Hak A.E. Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: the Rotterdam Study / Hak A.E., Pols H.A., Visser T.J. et al. // Ann. Intern. Med. – 2000. – Vol. 132, №4. – Р. 270–278.
Jing A. Development of Wistar rat model of insulin resistance / Jing A., Wang N., Yang M. et al. // World J. Gastroenterol. – 2005. – Vol. 11, №24. – P. 3675–3679.
Kim H.C. Multimarker prediction of coronary heart disease risk: the women’s health initiative / . Kim H.C., Greenland P., Rossouw J.E. et al. // J. Amer. Coll. Сardiol. – 2010. – Vol. 55, №19. – P. 2080–2091.
Plotz C. The Latex - Fixation Test. II. Results in Rheumatoid Artritis / Plotz C., Singer J. // Am. J. Med. – 1956. – V. 21, №8. – P. 893–897.
Rodondi N. Subclinical thyroid dysfunction, cardiac nction, and the risk of heart failure. The Cardiovascular Health study / Rodondi N., Bauer D. C. , Cappola A. R. et al. // J. Amer. Coll. Cardiol. – 2008. – Vol. 52, №14. – P. 1152–1159.
Trbojević B. Diagnosis of autoimmune thyroid disease / Trbojević B., Djurica S. // Srp. Arh. Celok. Lek. – 2005. – Vol. 133, Suppl. 1. – P. 25–33.
Türemen E.E. Endothelial dysfunction and low grade chronic inflammation in subclinical hypothyroidism due to autoimmune thyroiditis / Türemen E.E., Çetinarslan B., Şahin T. et al. // Endocr. J. – 2011. – Vol. 58, №5. – P. 349–354.