Рівень цистатину С та NT-pro-BNP у хворих на хронічну серцеву недостатність  залежно від внутрішньоміокардіального напруження лівого шлуночка

V.V. Syvolap; N.V. Tumanskaya; A.A. Popovych; L.M. Polyschuk

doi:10.14739/2310-1237.2012.3.17017

Authors

V.V. Syvolap
N.V. Tumanskaya
A.A. Popovych
L.M. Polyschuk

DOI:

https://doi.org/10.14739/2310-1237.2012.3.17017

Keywords:

Cystatin C, chronic heart failure, left ventricle, NT-pro-BNP, correlation connections

Abstract

This article demonstrates the changes of markers of Cystatin C and NT-pro-BNP content in serum of 111 patients with heart failure of ischemic genesis depending on the rate of intramyocardial tension of the left ventricle. It is shown significant increase Cystatin C and NT-pro-BNP levels blood serum taes place as intramyocardial tension of the left ventricle.

References

Панфилова Е.Ю. Новые биомаркеры сердечной недостаточности / Е.Ю. Панфилова, Е.Н. Данковцева, Д.А. Затейщиков // Фарматека. – 2008. – №12. – С. 14–19.

Association of Cystatin C With Left Ventricular Structure and Function: The Dallas Heart Study / Patel P.C., Ayers C.R., Murphy S.A. [et al.] // Circ. Heart Fail. – 2009. – Vol. 2. – P. 98–104.

Cystatin C and mortality risk in the elderly: the health, aging, and body composition study / Shlipak M.G., Wassel Fyr C.L., Chertow G.M. [et al.] // J. Am. Soc. Nephrol. – 2006. – Vol. 17. – P. 254–261.

Cystatin C concentration as a predictor of systolic and diastolic heart failure / Moran A., Katz R., Smith N. L. [et al.] // J. Card. Fail. – 2008. – Vol. 14, №1. – P. 19–26.

Cystatin C: a new marker of glomerular filtration rate in children independent of age and height / Bokenkamp A., Domanetzki M., Zinck R. [et al.] // Pediatrics. – 1998. – Vol. 101. – P. 875–881.

Cystatin-C and mortality in elderly persons with heart failure / Shlipak M. G., Katz R., Fried L. F. [et al.] // J. Am. Coll. Cardiol. – 2005. – Vol. 45. – P. 268–271.

Guidelines for the diagnosis and treatment of chronic heart failure / Task Force for the Diagnosis and Treatment of Chronic Heart Failure ESC // Eur. Heart J. – 2001. – Vol. 22. – P. 1527–1560.

Hall A. Structural basis for different inhibitory specificities of human cystatins C and D / Hall A., Ekiel I., Mason R. W. [et al.] // Biochemistry. – 1998. – Vol. 37. – P. 4071–4079.

Human evidence that the cystatin C gene is implicated in focal progression of coronary artery disease / Eriksson P., Deguchi H., Samnegard A. [et al.] // Arterioscler. Thromb. Vasc. Biol. – 2004. – Vol. 24. – P. 551e7.

Mussap M. Biochemistry and clinical role of human cystatin C / М. Mussap, М. Plebani // Crit. Rev. Clin. Lab. Sci. – 2004. – Vol. 41, №5–6. – P. 467–550.

Study group Prognostic value of cystatin C in acute heart failure in relation to other markers of renal function and NT-proBNP / Lassus J., Harjola V., Sund R. [et al.] // Europ. Heart J. – 2007. – Vol. 28. – P. 1841–1847.

Use of multiple biomarkers to improve the prediction of death from cardiovascular causes / Zethelius B., Berglund L., Sundström J. [et al.] // N. Engl. J. Med. – 2008. – Vol. 358, N 20. – P. 2107–2116.