Nutrition and cancer: modern aspects of a healthy lifestyle (literature review)
DOI:
https://doi.org/10.14739/2310-1237.2022.2.258362Keywords:
food, diet, cancer, ketogenic diet, Mediterranean diet, fastingAbstract
Despite significant improvements in screening, diagnosis and targeted therapy, cancer remains the second leading cause of death in the world. It is becoming increasingly clear that diet and lifestyle play a significant role in the development and progression of cancer. Thus, various dietary combinations can be proposed to reduce the risk of cancer and to improve the impact of basic therapy. Nutrition is closely linked to cancer. Food carcinogens, macronutrients, micronutrients such as vitamins A, C and D, dietary fiber, modulation of metabolism by diet, dietary supplements and anticancer agents in food affect the development of cancer. This article discusses research on the relationship between nutrition and cancer, as well as current dietary guidelines for reducing the risk of cancer.
The aim of the study is to analyze information from the professional literature on the influence of various nutritional regimes in cancer patients.
Conclusions. Proper nutrition can prevent the risk of cancer and improve the impact of treatment on the disease. Ketogenic diet is useful in combination with standard therapy on the basis of its ability to enhance the antitumor effects of classical chemotherapy and radiation therapy, its overall good safety and tolerability, as well as improving the quality of life. Mediterranean diet is a protective factor against cancer, due to the antioxidant and anti-inflammatory properties of the ingredients. Fasting is also a potentially effective strategy for inducing the differential stress resistance of cancer and normal cells as an adjunct to standard treatment. Promising benefits of vitamins in the prevention and treatment of cancer can be achieved through the use of new potent analogues, as well as combinations of vitamins in the early stages of cancer.
References
- Stenger, M. (2022, January 13). Global Burden of Cancer From 2010 to 2019. The ASCO post. https://ascopost.com/news/january-2022/global-burden-of-cancer-from-2010-to-2019/
- Fedorenko, Z. P., Mikhailovich, Y. Y., Gulak, L. O., Horokh, Ye. L., Ryzhov, A. Yu., Sumkina, O. V., & Kutsenko, L. B. (2021). Rak v Ukraini, 2019-2020. Zakhvoriuvanist, smertnist, pokaznyky diialnosti onkolohichnoi sluzhby [Cancer in Ukraine, 2019-2020. Morbidity, mortality, indicators of oncology service]. Bulletin of the National Cancer Registry of Ukraine, 22. [in Ukrainian]. http://www.ncru.inf.ua/publications/BULL_22/index.htm
- Aprile, G., Basile, D., Giaretta, R., Schiavo, G., La Verde, N., Corradi, E., Monge, T., Agustoni, F., & Stragliotto, S. (2021). The Clinical Value of Nutritional Care before and during Active Cancer Treatment. Nutrients, 13(4), 1196. https://doi.org/10.3390/nu13041196
- World Health Organization. (2022, February 3). Cancer. WHO. https://www.who.int/news-room/fact-sheets/detail/cancer
- Weber, D. D., Aminzadeh-Gohari, S., Tulipan, J., Catalano, L., Feichtinger, R. G., & Kofler, B. (2020). Ketogenic diet in the treatment of cancer - Where do we stand?. Molecular metabolism, 33, 102-121. https://doi.org/10.1016/j.molmet.2019.06.026
- Plotti, F., Terranova, C., Luvero, D., Bartolone, M., Messina, G., Feole, L., Cianci, S., Scaletta, G., Marchetti, C., Di Donato, V., Fagotti, A., Scambia, G., Benedetti Panici, P., & Angioli, R. (2020). Diet and Chemotherapy: The Effects of Fasting and Ketogenic Diet on Cancer Treatment. Chemotherapy, 65(3-4), 77-84. https://doi.org/10.1159/000510839
- Oliveira, C., Mattingly, S., Schirrmacher, R., Sawyer, M. B., Fine, E. J., & Prado, C. M. (2018). A Nutritional Perspective of Ketogenic Diet in Cancer: A Narrative Review. Journal of the Academy of Nutrition and Dietetics, 118(4), 668–688. https://doi.org/10.1016/j.jand.2017.02.003
- Weber, D. D., Aminazdeh-Gohari, S., & Kofler, B. (2018). Ketogenic diet in cancer therapy. Aging, 10(2), 164-165. https://doi.org/10.18632/aging.101382
- Cohen, C. W., Fontaine, K. R., Arend, R. C., Soleymani, T., & Gower, B. A. (2018). Favorable Effects of a Ketogenic Diet on Physical Function, Perceived Energy, and Food Cravings in Women with Ovarian or Endometrial Cancer: A Randomized, Controlled Trial. Nutrients, 10(9), 1187. https://doi.org/10.3390/nu10091187
- Klement, R. J., Champ, C. E., Kämmerer, U., Koebrunner, P. S., Krage, K., Schäfer, G., Weigel, M., & Sweeney, R. A. (2020). Impact of a ketogenic diet intervention during radiotherapy on body composition: III-final results of the KETOCOMP study for breast cancer patients. Breast cancer research : BCR, 22(1), 94. https://doi.org/10.1186/s13058-020-01331-5
- Talib, W. H., Mahmod, A. I., Kamal, A., Rashid, H. M., Alashqar, A., Khater, S., Jamal, D., & Waly, M. (2021). Ketogenic Diet in Cancer Prevention and Therapy: Molecular Targets and Therapeutic Opportunities. Current issues in molecular biology, 43(2), 558-589. https://doi.org/10.3390/cimb43020042
- Mentella, M. C., Scaldaferri, F., Ricci, C., Gasbarrini, A., & Miggiano, G. (2019). Cancer and Mediterranean Diet: A Review. Nutrients, 11(9), 2059. https://doi.org/10.3390/nu11092059
- Farinetti, A., Zurlo, V., Manenti, A., Coppi, F., & Mattioli, A. V. (2017). Mediterranean diet and colorectal cancer: A systematic review. Nutrition, 43-44, 83-88. https://doi.org/10.1016/j.nut.2017.06.008
- Tosti, V., Bertozzi, B., & Fontana, L. (2018). Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms. The journals of gerontology. Series A, Biological sciences and medical sciences, 73(3), 318-326. https://doi.org/10.1093/gerona/glx227
- Mirabelli, M., Chiefari, E., Arcidiacono, B., Corigliano, D. M., Brunetti, F. S., Maggisano, V., Russo, D., Foti, D. P., & Brunetti, A. (2020). Mediterranean Diet Nutrients to Turn the Tide against Insulin Resistance and Related Diseases. Nutrients, 12(4), 1066. https://doi.org/10.3390/nu12041066
- Turati, F., Carioli, G., Bravi, F., Ferraroni, M., Serraino, D., Montella, M., Giacosa, A., Toffolutti, F., Negri, E., Levi, F., & La Vecchia, C. (2018). Mediterranean Diet and Breast Cancer Risk. Nutrients, 10(3), 326. https://doi.org/10.3390/nu10030326
- Cho, A. R., Choi, W. J., Kwon, Y. J., Lee, H. S., Ahn, S. G., & Lee, J. W. (2020). Mediterranean Diet and Naltrexone/Bupropion Treatment for Weight Loss in Overweight and Obese Breast Cancer Survivors and Non-Cancer Participants: A Pilot Randomized Controlled Trial. Diabetes, metabolic syndrome and obesity : targets and therapy, 13, 3325-3335. https://doi.org/10.2147/DMSO.S269237
- Nencioni, A., Caffa, I., Cortellino, S., & Longo, V. D. (2018). Fasting and cancer: molecular mechanisms and clinical application. Nature reviews. Cancer, 18(11), 707-719. https://doi.org/10.1038/s41568-018-0061-0
- Sadeghian, M., Rahmani, S., Khalesi, S., & Hejazi, E. (2021). A review of fasting effects on the response of cancer to chemotherapy. Clinical nutrition, 40(4), 1669-1681. https://doi.org/10.1016/j.clnu.2020.10.037
- Clifton, K. K., Ma, C. X., Fontana, L., & Peterson, L. L. (2021). Intermittent fasting in the prevention and treatment of cancer. CA: a cancer journal for clinicians, 71(6), 527-546. https://doi.org/10.3322/caac.21694
- De Groot, S., Lugtenberg, R. T., Cohen, D., Welters, M., Ehsan, I., Vreeswijk, M., Smit, V., de Graaf, H., Heijns, J. B., Portielje, J., van de Wouw, A. J., Imholz, A., Kessels, L. W., Vrijaldenhoven, S., Baars, A., Kranenbarg, E. M., Carpentier, M. D., Putter, H., van der Hoeven, J., Nortier, J., … Dutch Breast Cancer Research Group (BOOG) (2020). Fasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trial. Nature communications, 11(1), 3083. https://doi.org/10.1038/s41467-020-16138-3
- Zorn, S., Ehret, J., Schäuble, R., Rautenberg, B., Ihorst, G., Bertz, H., Urbain, P., & Raynor, A. (2020). Impact of modified short-term fasting and its combination with a fasting supportive diet during chemotherapy on the incidence and severity of chemotherapy-induced toxicities in cancer patients - a controlled cross-over pilot study. BMC cancer, 20(1), 578. https://doi.org/10.1186/s12885-020-07041-7
- Clement, D. S., Tesselaar, M. E., van Leerdam, M. E., Srirajaskanthan, R., & Ramage, J. K. (2019). Nutritional and vitamin status in patients with neuroendocrine neoplasms. World journal of gastroenterology, 25(10), 1171-1184. https://doi.org/10.3748/wjg.v25.i10.1171
- Glorieux, C., & Buc Calderon, P. (2021). Vitamin C (Ascorbate) and Redox Topics in Cancer. Antioxidants & redox signaling, 35(14), 1157-1175. https://doi.org/10.1089/ars.2020.8233
- Böttger, F., Vallés-Martí, A., Cahn, L., & Jimenez, C. R. (2021). High-dose intravenous vitamin C, a promising multi-targeting agent in the treatment of cancer. Journal of experimental & clinical cancer research : CR, 40(1), 343. https://doi.org/10.1186/s13046-021-02134-y
- Van Gorkom, G., Lookermans, E. L., van Elssen, C., & Bos, G. (2019). The Effect of Vitamin C (Ascorbic Acid) in the Treatment of Patients with Cancer: A Systematic Review. Nutrients, 11(5), 977. https://doi.org/10.3390/nu11050977
- Bazzan, A. J., Zabrecky, G., Wintering, N., Newberg, A. B., & Monti, D. A. (2018). Retrospective Evaluation of Clinical Experience With Intravenous Ascorbic Acid in Patients With Cancer. Integrative cancer therapies, 17(3), 912-920. https://doi.org/10.1177/1534735418775809
- Bahrami, A., & Sahebkar, A. (2020). Vitamin D as a Potential Therapeutic Option in Cancer Treatment: Is There a Role for Chemoprevention?. Anti-cancer agents in medicinal chemistry, 20(18), 2138-2149. https://doi.org/10.2174/1871520620999200729192728
- Li, Z., Shi, J., Wang, Z., Chen, H., & Liu, Y. (2021). Nutrient Status of Vitamin D among Cancer Patients. Zhongguo fei ai za zhi = Chinese journal of lung cancer, 24(5), 345-350. https://doi.org/10.3779/j.issn.1009-3419.2021.101.10
- Markowska, A., Antoszczak, M., Kojs, Z., Bednarek, W., Markowska, J., & Huczyński, A. (2020). Role of vitamin D3 in selected malignant neoplasms. Nutrition, 79-80, 110964. https://doi.org/10.1016/j.nut.2020.110964
- McDonnell, S. L., Baggerly, C. A., French, C. B., Baggerly, L. L., Garland, C. F., Gorham, E. D., Hollis, B. W., Trump, D. L., & Lappe, J. M. (2018). Breast cancer risk markedly lower with serum 25-hydroxyvitamin D concentrations ≥60 vs <20 ng/ml (150 vs 50 nmol/L): Pooled analysis of two randomized trials and a prospective cohort. PloS one, 13(6), e0199265. https://doi.org/10.1371/journal.pone.0199265
- Li, K., & Zhang, B. (2020). The association of dietary β-carotene and vitamin A intake on the risk of esophageal cancer: a meta-analysis. Revista espanola de enfermedades digestivas, 112(8), 620-626. https://doi.org/10.17235/reed.2020.6699/2019
- Wang, Q., & He, C. (2020). Dietary vitamin A intake and the risk of ovarian cancer: a meta-analysis. Bioscience reports, 40(4), BSR20193979. https://doi.org/10.1042/BSR20193979
- Tratnjek, L., Jeruc, J., Romih, R., & Zupančič, D. (2021). Vitamin A and Retinoids in Bladder Cancer Chemoprevention and Treatment: A Narrative Review of Current Evidence, Challenges and Future Prospects. International journal of molecular sciences, 22(7), 3510. https://doi.org/10.3390/ijms22073510
- He, J., Gu, Y., & Zhang, S. (2018). Vitamin A and Breast Cancer Survival: A Systematic Review and Meta-analysis. Clinical breast cancer, 18(6), e1389-e1400. https://doi.org/10.1016/j.clbc.2018.07.025
Downloads
Published
How to Cite
Issue
Section
License
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.





