Aim: to analyse a clinical case of echinococcosis of rare localisation – in the soft tissues of the thigh, taking into account the diagnostic tactics used and an individualised approach to antiparasitic treatment.

Materials and methods. The medical records of patient S., 38 years old, who underwent hospital treatment and subsequent long-term outpatient observation for echinococcosis during 2022–2024 at the Medical Educational and Scientific Center “University Clinic” of Zaporizhzhia State Medical and Pharmaceutical University were analysed.

Results. The study demonstrates the clinical observation of an extremely rare variant of Echinococcus granulosus cyst localisation in the subcutaneous tissue of the thigh. An integrated approach to the diagnosis of echinococcosis using serological, pathomorphological, and various imaging methods made it possible to identify the presence of a combined lesion. Taking into account the multiple localisation of echinococcal cysts, the patient’s treatment approach included surgical removal of the cyst from the subcutaneous tissue of the right thigh and long-term conservative drug treatment with albendazole, considering the small size of the echinococcal cyst in the right lung. Based on the results of seronegativity and calcification of the cyst in the lung, albendazole therapy was discontinued.

Conclusions. This clinical example confirms the need for a comprehensive diagnostic approach to the verification of rare and multiple locations of Echinococcus granulosus cysts and individualised treatment.