Pathomorphosis of stage IIB cervical cancer in preoperative radiation therapy
DOI:
https://doi.org/10.14739/2310-1237.2013.2.17366Keywords:
cervical cancer, radial therapy, pathomorphosisAbstract
With the purpose of study of medical radiation pathomorphosis morphological research of 53 cases of stage IIB cervical cancer was conducted during the application of preoperative radiation therapy. The degree of expression of medical pathomorphosis of parenchymal-stromal components was assessed on the scale of G.A. Lavnikova (1976). The analysis of medical pathomorphosis has shown that I degree lesion was fixed in 2 cases (3,7%), II – in 20 (37,7%), III – in 11 (20,8%), IV – in 20 (37,7%). The index of damage is 56,7%. High frequency (96,2%) of radiation pathomorphosis development confirms the radiosensitivity of stage IIB cervical cancer. Application of preoperative radiation therapy determines the devitalisation of tumour parenchyma mainly in superficial areas and has the focal character. Development of pathomorphosis does not depend on the form of tumour growth, but histological variant of squamous cell carcinoma, namely non-keratinizing (77,4%) can be an indication for preoperative radiation therapy. The obtained results of radiation pathomorphosis assessment allow planning the subsequent tactics of management of patients with the application of additional methods of treatment.References
Абраменко И.В. Оценка параметров апоптоза в диагностике онкологических заболеваний, их прогнозе и оптимизации схем терапии / И.В. Абраменко, А.А. Фильченко // Вопр. онкол. – 2003. – Т. 49, №1. – С. 21–30.
Галил-Оглы Г.А. Терапевтический патоморфоз при различных видах предоперационной терапии рака шейки матки / Г.А. Галил-Оглы, Н.Л. Чазова, Л.А. Алипченко и др. // Весник РНЦРР Минздрава России. – 2003. – №3. – С. 62–63.
Лавникова Г.А. Некоторые закономерности лучевого патоморфоза опухолей человека и их практическое использование // Вестн. АМН СССР. – 1976. – №6. – С. 13–19.
Рак в Україні, 2009–2010 / З.П. Федоренко, А.В. Гайсенко, Л.О. Гулак та ін. // Бюлетень Національного канцер-реєстру. – 2011. – №12. – С. 57–58.
Семикоз Н.Г. Променевий патоморфоз органів і тканин малого тазу при лікуванні раку тіла та шийки матки / Н.Г. Семикоз, В.Г. Шлопов – Д.: УкрНТЕК, 2000. – 146 с.
Чазова Н.Л. Морфологическая характеристика леченного рака шейки матки (изучениет терапевтического патоморфоза) / Н.Л. Чазова, А.М. Берщанская // Весник РНЦРР Минздрава России. – 2006. – №6. – С. 41–50.
Hirakawa M. Predictive factor of distant recurrence in locally advanced squamous cell carcinoma of the cervix treated with concurrent chemoradiotherapy / Hirakawa M., Nagai Y., Inamine M. et al. // Gynecol. Oncol. – 2008. – Vol. 108 (1). – Р. 126–129.
Rose P.G. Concurrent chemoradiation for locally advanced carcinoma of the cervix: where are we in 2006? / Rose PG // Ann. Oncol. – 2006. – Vol. 17 (Suppl. 10). – Р. 224–229.
Sehouli J. A randomized phase III adjuvant study in high-risk cervical cancer: simultaneous radiochemotherapy with cisplatin (S-RC) versus systemic paclitaxel and carboplatin followed by percutaneous radiation (PC-R): a NOGGO-AGO Intergroup Study / Sehouli J, Runnebaum IB, Fotopoulou C. // Ann Oncol. – 2012. – Feb 21.
Vale C. Chemoradiotherapy for Cervical Cancer Meta-Analysis. Reducing uncertainties about the effects of chemoradiotherapy for cervical cancer: a systematic review and meta-analysis of individual patient data from 18 randomized trials / Vale C., Tierney J., Stewart L. et al. // J. Clin. Oncol. – 2008. – Vol. 26. – Р. 5802–5812.
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