Vimentin expression in the tumor cells of carcinomas of different organs and different histological types


  • I. V. Vasilenko
  • R. B. Kondratjuk
  • I. A. Kolesnikova
  • A. G. Kudrjashov



epithelial-mesenhymal transition, stomach neoplasms, lung neoplasms, kidney neoplasms


Aims. Epithelial- mesenсhymal transition endows tumors with such qualities as ability to invasion and metastasis development, prevents their apoptosis and ageing, promotes angiogenesis, immunosupression, resistance to chemo- and radiotherapy.

Methods and results. For the purpose of revealing complete epithelial-mesenchymal transition with expression of vimentin 24cases of gastric carcinoma, 46 cases of pulmonary carcinoma and 15 cases of renal cell carcinoma were studied immunohistochemicaly. Expression of vimentin was revealed more often in renal carcinomas (86,7%), adenocarcinomas of the lung (44,1%) and diffuse gastric carcinomas (80%). Authentically lower frequency expression of vimentin in intestinal gastric cancer (14,3%) and squamous cell and neuroendicrinal lung cancer (16.7%).

Conclusion. The expression of vementin may be connected with embrional histogenesis of organ, peculiarities of cancerogenesis and also with tumor progression.


Micalizzi, D. S., Farabaugh, S. M. & Ford, H. L. (2010) Epithelial-mesenchymal trnsition in cancer: parallels between normal development and tumor progresion. J. Mammary Gland Biol. Neoplasia, 15, 117–134. doi: 10.1007/s10911-010-9178-9.

Tun, H. W., Copland, J. A., Creighton, C., Anastasiadis, P. Z., Sinha, M., Luxon, B. A., et al. (2010). Pathway Signature and Cellular Differentiation in Clear Cell Renal Cell Carcinoma. PLoS ONE, 5(5), e10696. DOI: 10.1371/journal.pone.0010696.

Sato, M., Shames, D. S., & Hasegawa, Y. (2012). Emerging evidence of epithelial-to-mesenchymal transition in lung carcinogenesis. Respirology, 17(7), 1048–1059. doi: 10.1111/j.1440_1843.2012.02173.

Bermudez, O., Hennen, E., Koch, I., Lindner, M., Eickelberg, O., & Katoh, M. (2013). Gli1 Mediates Lung Cancer Cell Proliferation and Sonic Hedgehog-Dependent Mesenchymal Cell Activation. PLoS ONE, 8(5), e63226. doi: 10.1371/j.

Uhlenhaut, N. H., & Treier, M. (2008). Transcriptional regulators in kidney disease: gatekeepers of renal homeostasis. Trends in Genetics, 24(7), 361–371. doi: 10.1016/j.tig.2008.05.001.

Vasilenko, I. V., Sadchikov, V. D. & Galakhin, K. A. (2001) Predrak i rak zheludka: e`tiologoya, patogenez, morfologiya, lechebnyj patomorfoz [Precancer and cancer of stomach: etiology, pathogenesis, morphology, treatment pathomorphosis]. Kiev: Knigaplyus [in Ukrainian].

Kolesnik, A. P., Shevchenko, A. I., Tumanskij, V. A., Evseev, A. V. & Shishkin, M. A. (2013) Prognosticheskaya rol` e`kspressii receptorov k e`pidermal`nym faktoram rosta u bol`nykh s I–II stadiej nemelkokletochnogo raka legkogo [Prognostic role of expression receptor of epidermal growth factor in patients with I–II stage non-small cell lung carcinoma]. Pathologia, 2, 17–21.

Petrov, S. V. & Rajkhlin, N. T. (2012) Rukovodstvo po immunogistokhimicheskoj diagnostike opukholej cheloveka [Manual on immunohistochemical diagnostics of human tumours. 4-th edition]. Kazan [in Russian].

Prudkin, L., Moran, C., Bekele, B. N., Brown, K. C., Tang, X., Behrens, C., et al. (2009). Epithelial-to-mesenchymal transition in the development and progression of adenocarcinoma and squamous cell carcinoma of the lung.Modern Pathology, 22(5), 668–678.

Thierry, J. P., Acloque, H., Huang, R. Y. & Nieto, M. A. (2009) Epithelial-mesenchymal transition ns in development and disease. Cell., 139(5), 871–890.

König, K., Heukamp, L. C., Meder, L., Lawson, V., Buettner, R., Magin, T. M., et al. (2013). Loss of the Keratin Cytoskeleton Is Not Sufficient to Induce Epithelial Mesenchymal Transition in a Novel KRAS Driven Sporadic Lung Cancer Mouse Model. PLoS ONE, 8(3), e57996.

Dauphin, M., Barbe, C. & Lemaire, S. (2013) Vimentin expression predicts the occurence of metastases in non small cell lung cancinomas. Lung cancer, 8, 117–122.

How to Cite

Vasilenko IV, Kondratjuk RB, Kolesnikova IA, Kudrjashov AG. Vimentin expression in the tumor cells of carcinomas of different organs and different histological types. Pathologia [Internet]. 2014Jun.18 [cited 2024Mar.2];(1). Available from:



Original research