Dynamics of leukocyte inflammatory markers in patients with ST-elevation myocardial infarction depending on left ventricle ejection fraction

Authors

DOI:

https://doi.org/10.14739/2310-1237.2022.3.267268

Keywords:

leukocytes, markers of inflammation, ST segment elevation myocardial infarction

Abstract

Aim: to evaluate the dynamics of leukocyte inflammatory markers in patients with ST-elevation myocardial infarction (STEMI) after percutaneous coronary intervention (PCI) depending on ejection fraction of left ventricular (LV).

Material and methods. The study group consisted of 23 consecutive patients with STEMI admitted to the Regional Clinical Cardiology Center in Chernivtsi, who underwent successful reperfusion treatment by PCI. To evaluate inflammatory markers, a complete blood count (CBC) was assessed at admission, and on day 10 of hospital stay on the background of optimal drug therapy.

Results. It was found that patients with STEMI and reduced left ventricular ejection fraction (LVEF) (group 2) at admission had a significantly higher leukocyte count (P < 0.05) and an increase in the absolute neutrophils (P < 0.01) with significantly higher inflammatory markers: neutrophil-to-lymphocyte ratio (NLR) (P < 0.01), monocyte-to-lymphocyte ratio (MLR), systemic immune inflammation index (SII) (P < 0.01), systemic inflammation response index (SIRI) (P < 0.01), aggregate index of systemic inflammation (AISI) (P < 0.05), and integrated index of inflammation (III) (P < 0.05). On day 10 of treatment, the analysis of inflammatory markers showed that in patients of group 2, NLR (P < 0.01) and SII (P < 0.05) remained significantly higher than in STEMI patients with preserved LVEF (group 1). At the study of the changes in leukocyte-based inflammatory markers in STEMI patients under the influence of optimal drug therapy after PCI, a decrease (P < 0.05) in NLR, MLR, SII, SIRI, IIII, and an increase in (P < 0.05) LMR were observed.

Conclusions. CBC of inflammatory markers at admission identifies the risk of adverse cardiovascular events and determines measures to regulate the activity of the inflammatory process in STEMI.

Author Biographies

V. K. Tashchuk, Bukovinian State Medical University, Chernivtsi, Ukraine

MD, PhD, DSc, Professor, Head of the Department of Internal Medicine, Physical Rehabilitation and Sport Medicine

R. A. Bota, Bukovinian State Medical University, Chernivtsi, Ukraine

MD, Postgraduate student of the Department of Internal Medicine, Рhysical Rehabilitation and Sport Medicine

M. V. O. Al Salama, Bukovinian State Medical University, Chernivtsi, Ukraine

MD, PhD, Associate Professor of the Department of Internal Medicine, Physical Rehabilitation and Sport Medicine

References

Si, Y., Liu, J., Shan, W., Zhang, Y., Han, C., Wang, R., & Sun, L. (2020). Association of lymphocyte-to-monocyte ratio with total coronary plaque burden in patients with coronary artery disease. Coronary artery disease, 31(7), 650-655. https://doi.org/10.1097/MCA.0000000000000857

Dziedzic, E. A., Gąsior, J. S., Tuzimek, A., Dąbrowski, M., & Jankowski, P. (2022). Neutrophil-to-Lymphocyte Ratio Is Not Associated with Severity of Coronary Artery Disease and Is Not Correlated with Vitamin D Level in Patients with a History of an Acute Coronary Syndrome. Biology, 11(7), 1001. https://doi.org/10.3390/biology11071001

Yoon, G. S., Choi, S. H., Woo, S. I., Baek, Y. S., Park, S. D., Shin, S. H., Kim, D. H., Kwan, J., Lee, M. J., & Kwon, S. W. (2021). Neutrophil-to-Lymphocyte Ratio at Emergency Room Predicts Mechanical Complications of ST-segment Elevation Myocardial Infarction. Journal of Korean medical science, 36(19), e131. https://doi.org/10.3346/jkms.2021.36.e131

Fonseca, F. A., & Izar, M. C. (2022). Role of Inflammation in Cardiac Remodeling After Acute Myocardial Infarction. Frontiers in physiology, 13, 927163. https://doi.org/10.3389/fphys.2022.927163

Tavares, F., Moraes, P. I. M., Souza, J. M., Barbosa, A. H., Santos, E. M., Marcondes, J. A., Oliveira, M. D., Gonçalves, I., Jr, Espírito Santo, C. V. A., Bianco, H. T., Fonseca, F. A. H., Moisés, V., & Caixeta, A. (2022). Prognostic role of neutrophil-to-lymphocyte ratio in patients with ST-elevation myocardial infarction undergoing to pharmaco-invasive strategy. Cardiovascular revascularization medicine : including molecular interventions, 34, 99-103. https://doi.org/10.1016/j.carrev.2021.01.027

Anzai, A., Ko, S., & Fukuda, K. (2022). Immune and Inflammatory Networks in Myocardial Infarction: Current Research and Its Potential Implications for the Clinic. International journal of molecular sciences, 23(9), 5214. https://doi.org/10.3390/ijms23095214

Kovalenko, V., Dolzhenko, M., & Potashev, S. (2018). Nastanovy z klinichnoi ekhokardiohrafii [Guidelines for clinical echocardiography]. Kyiv: Naukova dumka. [in Ukrainian].

Li, Q., Ma, X., Shao, Q., Yang, Z., Wang, Y., Gao, F., Zhou, Y., Yang, L., & Wang, Z. (2022). Prognostic Impact of Multiple Lymphocyte-Based Inflammatory Indices in Acute Coronary Syndrome Patients. Frontiers in cardiovascular medicine, 9, 811790. https://doi.org/10.3389/fcvm.2022.811790

Dai, K., Li, Z., Luo, Y., Xiong, Q., Xiong, Y., Song, Z., & Xiong, W. (2022). The Predictive Value of the Monocyte-to-Lymphocyte Ratio and Monocyte-to-Haematocrit Ratio for Cardiac Rupture Patients with Acute Myocardial Infarction: A Propensity Score Matching Analysis. Risk management and healthcare policy, 15, 37-44. https://doi.org/10.2147/RMHP.S348894

Urbanowicz, T., Michalak, M., Olasińska-Wiśniewska, A., Rodzki, M., Witkowska, A., Gąsecka, A., Buczkowski, P., Perek, B., & Jemielity, M. (2022). Neutrophil Counts, Neutrophil-to-Lymphocyte Ratio, and Systemic Inflammatory Response Index (SIRI) Predict Mortality after Off-Pump Coronary Artery Bypass Surgery. Cells, 11(7), 1124. https://doi.org/10.3390/cells11071124

Han, K., Shi, D., Yang, L., Wang, Z., Li, Y., Gao, F., Liu, Y., Ma, X., & Zhou, Y. (2022). Prognostic value of systemic inflammatory response index in patients with acute coronary syndrome undergoing percutaneous coronary intervention. Annals of medicine, 54(1), 1667-1677. https://doi.org/10.1080/07853890.2022.2083671

Bao, K., Huang, H., Huang, G., Wang, J., Liao, Y., Pan, Y., Chen, W., Lu, J., Yang, Y., Huang, Z., Chen, S., Chen, K., & Chen, L. (2021). Platelet-to-hemoglobin ratio as a valuable predictor of long-term all-cause mortality in coronary artery disease patients with congestive heart failure. BMC cardiovascular disorders, 21(1), 618. https://doi.org/10.1186/s12872-021-02423-6

Libby P. (2021). Inflammation in Atherosclerosis-No Longer a Theory. Clinical chemistry, 67(1), 131-142. https://doi.org/10.1093/clinchem/hvaa275

Chan, Y. H., & Ramji, D. P. (2020). A perspective on targeting inflammation and cytokine actions in atherosclerosis. Future medicinal chemistry, 12(7), 613-626. https://doi.org/10.4155/fmc-2019-0301

King, A. H., Kwan, S., Schmaier, A. H., Kumins, N. H., Harth, K. C., Colvard, B. D., Wong, V. L., Kashyap, V. S., & Cho, J. S. (2021). Elevated neutrophil to lymphocyte ratio is associated with decreased amputation-free survival after femoropopliteal percutaneous revascularization. International angiology, 40(5), 442-449. https://doi.org/10.23736/S0392-9590.21.04699-X

Zhang, S., Diao, J., Qi, C., Jin, J., Li, L., Gao, X., Gong, L., & Wu, W. (2018). Predictive value of neutrophil to lymphocyte ratio in patients with acute ST segment elevation myocardial infarction after percutaneous coronary intervention: a meta-analysis. BMC cardiovascular disorders, 18(1), 75. https://doi.org/10.1186/s12872-018-0812-6

Published

2023-01-27

How to Cite

1.
Tashchuk VK, Bota RA, Al Salama MVO. Dynamics of leukocyte inflammatory markers in patients with ST-elevation myocardial infarction depending on left ventricle ejection fraction. Pathologia [Internet]. 2023Jan.27 [cited 2024Oct.8];19(3):195-200. Available from: http://pat.zsmu.edu.ua/article/view/267268

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Section

Original research