Determination of muscle differentiation markers SMA and MSA in CD117-positive and CD117-negative gastrointestinal stromal tumors of different malignant potential

Authors

  • I. S. Shpon’ka
  • V. R. Yakovenko

DOI:

https://doi.org/10.14739/2310-1237.2014.2.28561

Keywords:

Gastrointestinal Stromal Tumors, MSA, SMA, Neoplasms

Abstract

Aim. To determinate the muscle differentiation markers SMA and MSA in CD117-positive and CD117-negative gastrointestinal stromal tumors of different malignant potential.

Mеthods and results. Gastrointestinal stromal tumors (GIST) require a thorough differential diagnosis with smooth muscle tumors (benign and malignant) of the gastrointestinal tract. In order to determine the relationships between the clinical (age, localization of the primary tumor) and morphological (histological type of structure, expression of markers of histogenesis - CD117 and proliferative activity - Ki-67) characteristics of GIST and expression of markers of muscle differentiation we studied character of coloring SMA, MSA in the 47 cases (immunohistochemical method).

Сonclusion. It was established, that MSA-positive GIST were found in 6.4%. Distribution of SMA-positive cases in groups with different clinical and morphological characteristics is similar. In our study, we found no prognostic value of the marker SMA, although samples with high levels of expression of marker Ki-67 are more common among SMA-positive cases (p> 0.05).

References

Miettinen, M., & Lasota, J. (2011). Histopathology of gastrointestinal stromal tumor. Journal of surgical oncology, 104(8), 865–873. doi: 10.1002/jso.21945.

Selcukbiricik, F., Yalçın, S., Tural, D., Erdamar, S., Demir, G., Doğusoy, G., & Mandel, N. M. (2012). Gastrointestinal stromal tumors in Turkey: experiences from

Hamilton, S.R., Aaltonen, L.A. (2000). World Health Organisation classificatoin of tumors. Pathology and genetics of tumors of the digestive system. Lyon: IARC Press.

Demetri, G. D., Benjamin, R. S., Blanke, C. D., Blay, J. Y., Casali, P., Choi, H. & Zalcberg, J. (2007). NCCN Task Force report: management of patients with gastrointestinal stromal tumor (GIST)-update of the NCCN clinical practice guidelines. Journal of the National Comprehensive Cancer Network: JNCCN, 5, 1–29.

Joensuu, H., Hohenberger, P., & Corless, C. L. (2013). Gastrointestinal stromal tumour. The Lancet, 382(9896), 973–983. doi: 10.1016/S0140-6736(13)60106-3.

Odze, R. D., Goldblum, J. R., & Crawford, J. M. (2004). Surgical pathology of GI tract, liver, biliary tract, and pancreas. New York.

Belev, B., Brčić, I., Prejac, J., Golubić, Z. A., Vrbanec, D., Božikov, J., & Razumović, J. J. (2013). Role of Ki-67 as a prognostic factor in gastrointestinal stromal tumors. World journal of gastroenterology: WJG, 19(4), 523. doi: 10.3748/wjg.v19.i4.523.

Fletcher, C. D., Berman, J. J., Corless, C., Gorstein, F., Lasota, J., Longley, B. J. & Weiss, S. W. (2002). Diagnosis of gastrointestinal stromal tumors: a consensus approach. International Journal of Surgical Pathology, 10(2), 81–89. doi: 10.1177/106689690201000201.

Kornilova, A. G., Kogoniya, L. M., Mazurin, V. S., Bordanov, S. V. & Okseniuk, O. S. (2014). Gastrointestinal'nye stromal'nye opukholi: sovremennaya klassifikaciya, differencial'naya diagnostika i faktory prognoza. E`ffectyvna farmakoterapiya, 14(1), 20–23. [in Russian].

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How to Cite

1.
Shpon’ka IS, Yakovenko VR. Determination of muscle differentiation markers SMA and MSA in CD117-positive and CD117-negative gastrointestinal stromal tumors of different malignant potential. Pathologia [Internet]. 2014Oct.1 [cited 2024Dec.25];(2). Available from: http://pat.zsmu.edu.ua/article/view/28561

Issue

No. 2 (2014)

Section

Original research

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