Correlations between clinical, laboratory and morphological parameters of endothelial dysfunction and vascular-platelet hemostasis in patients with type 2 diabetes mellitus and hypertension with poor glycemic compensation
DOI:
https://doi.org/10.14739/2310-1237.2014.3.36554Keywords:
Type 2 Diabetes Mellitus, Hypertension, HemostasisAbstract
Aim. Many questions about the relationship between endothelial dysfunction and morphological substrate of hemostasis damage that occur during the progress of type 2 diabetes mellitus and arterial hypertension require clarification and further advance.
Methods and results. In 78 patients with poor glycemic compensation associations between endothelial dysfunction, degree of renal function damage, lipidemic profile and morphological changes of vascular-platelet hemostasis were identified using clinical, laboratory, morphological methods and correlational analysis.
Conclusion. It has been established that in the poor glycemic control against the background of significant strengthening relationships between indicators of endothelial dysfunction and damaged platelet hemostasis extremely dense correlations of ultrastructural characteristics of platelets with clinical and laboratory signs of nephropathic and dyslipidemic changes are formed.
References
Dedov, I. I. & Shestakova, M. V. (Eds.) (2011) Sakharnyj diabet: ostrye i khronicheskie oslozhneniya [Diabetes: acute and chronic complications]. Moscow: Medicinskoe informacionnoe agentstvo [in Russian].
Epstein, M. (1997) Diabetes and hypertension: the bad companions. Hypertension, 15(2), 55–62.
Torimoto, K., Okada, Y., Mori, H. & Tanaka, Y. (2013) Relationship between fluctuations in glucose levels measured by continuous glucose monitoring and vascular endothelial dysfunction in type 2 diabetes mellitus. Cardiovasc Diabetol, 13, 18–24. doi: 10.1186/1475-2840-12-1.
Xu, J. & Zou, M.N. (2009) Molecular insights and therapeutic targets for diabetic endothelial dysfunction. Circulation, 13, 1266–1286. doi: 10.1161/CIRCULATIONAHA.108.835223.
Demirtunc, R., Duman, D. & Basar, M. (2009) The relationship between glycemic control and platelet activity in type 2 diabetes mellitus. J Diabetes Complications, 23(2), 89–94. doi: 10.1016/j.jdiacomp.2008.01.006.
Lusher, T.F. & Barton, M. (1997) Biology of the endothelium. Clin Cardiol, 10(11), 3–10.
Ametov, A. S. (2012) Sakharnyj diabet 2 tipa. Problemy i resheniya [Type 2 diabetes mellitus. Problems and Solutions]. Moscow: GEOTAR-Media. [In Russian].
Mathewkutty, S. & McGuire, D. K. (2009) Platelet perturbations in diabetes: implications for cardiovascular disease risk and treatment. Expert Rev Cardiovasc Ther, 7(5), 541–549. doi: 10.1586/erc.09.30.
Martin-Gallan, P., Carrascosa, A., Gussinye, M. & Dominguez, C. (2003) Biomarkers of diabetes-associated oxidative stress and antioxidant status in young diabetic patients with or without subclinical complications. Free Rad Biol Med, 34(12), 1563–1574. doi: 10.1016/S0891-5849(03)00185-0.
Heude, B. (2003) Cognitive decline and fatty acid composition of erythrocyte membranes. Amer J Clin Nutrition, 77(4), 803–808.
Vitkovsky, Yu. A., Kuznik, B. I. & Solpov, A. V. (2006) Patogeneticheskoe znachenie limfocitarno-trombocitarnoj adgezii [Pathogenetic significance of lymphocyte-platelet adhesion]. Medicinskaya immunologiya, 5, 745–752. [in Russian].
Alekseev, V. V. & Karpishchenko, A. I. (2012) Medicinskie laboratornye tehnologii. Rukovodstvo po klinicheskoj laboratornoj diagnostike [Medical laboratory technology. Manual of Clinical Laboratory Diagnostics]. Moscow: GEOTAR-Media. [in Russian].
Sawatzke, C. L. & Solomons, C. C. (1980) Fixation and embedding of small volumes of platelets for transmission electron microscopy. J Clin Pathol, 33(6), 600–602. doi:10.1136/jcp.33.6.600.
Mironov, A. A., Komissarchik, Ya. Yu. & Mironov, V. A. (1994) Metody e`lektronnoj mikroskopii v biologii i medicine [Electron microscopy methods in biology and medicine]. Saint Petersburg: Nauka. [in Russian].
Medvedev, I. N., Savchenko, A. P. & Zavalishina, S. Yu. (2009) Metodicheskie podkhody k issledovaniyu reologicheskikh svojstv krovi pri razlichnykh sostoyaniyakh [Methodology of blood rheology assessment in various clinical situations]. Rossijskij kardiologicheskij zhurnal, 5, 42–45. [in Russian].
Lakin, G. F. (1990) Biometriya [Biometrics]. Moscow: Vysshaya shkola. [in Russian].
Downloads
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (SeeThe Effect of Open Access).
