Pathomorphological characteristic of the impact of foam sclerosant on the venous wall in case of varicose disease
DOI:
https://doi.org/10.14739/2310-1237.2014.3.37027Keywords:
varicose disease, polidocanol, vein morphology, experimentAbstract
In treatment of varicose disease methods of intraoperative phlebosclerotic obliteration involving injection of sclerosant into vein lumen come to the fore. Issues of morphological changes in venous wall are actual and unstudied.
The aim was to characterize morphological changes in the wall s of veins in the early and distant periods after the injection of foam polidocanol of different concentrations into patients’ varicose veins and into veins of experimental animals.
Methods and results. Segments of veins were investigated using the light and electron microscopy. It was confirmed that application of foam polidocanol for 10 minutes both in patients and rats influences endothelium cells and causes their damage. In vasa vasorum we saw hyperemia, stasis, thrombosis and in venous wall oedema and diapedesis of erythrocytes.
Conclusion. We revealed in experiment that in remote period (after 1 month) the injection of sclerosant leads to vessel obstruction with fibrosis.
References
Khitar`yan, A. H., Gusarev, D. A., Veliev, K. S., Ledenev, A. A., & Mazur, D. V. (2012) Bezopasnost' foam-form skleroterapii – e`ksperimental'no-patomorfologicheskoe issledovanie [The safety of foam-form sclerotherapy – experimental-pathomorphological study]. Flebologija, 2, 63. [in Russian].
Hnatiuk, M. S., & Zyma, I. Ya. (2011). Remodeliuvannia poverkhnevoi venoznoi systemy pry riznykh formakh varykoznoi khvoroby nyzhnikh kintsivok [Remodelling of superficial venous system at different forms of varicose illness of lower extremities]. Shpytalna khirurhiia, 1, 9–12. [in Ukrainian].
Irkin, I. V., Titova, Yu. P., Bondarenko, Yu. I., Palamarchuk, V. I., & Zaritska, V. I. (2014). Morfolohichna kharakterystyka zmin, sprychynenykh diieiu pinnoi formy polidokanolu v eksperymenti [Morphological characteristics of changes caused by foam-form polidocanol under experiment]. Khirurhiia Ukrainy, 3, 89–94. [in Ukrainian].
Irkin, I. V., Khodos, V. A., Zaritska, V. I., & Titova, Yu. P. (2012) Morfolohichni zminy v stintsi veny pry mikropinnii sklerokhirurhii varykoznoi khvoroby [Morphological changes in venous walls caused by microfoam sclerotic surgery of varicosity]. Patolohiia, 2, 79–83. [in Ukrainian].
Napalkov, N. I. (2009). Lechenie varikoznykh rasshirenij ven nizhnikh konechnostej [The treatment of varicose veins of the lower extremities]. Flebolohiia, 4, 63−71. [in Russian].
Bojko, V. V., Prasol, V. A., Rudenko, E. A., & Remnyova, N. A. (2013). Sravnitel'naya morfologicheskaya kharakteristika komponentov stenki varikoznykh ven posle provedeniya skleroterapii i e`ndovaskulyarnoj lazernoj koagulyacii [Comparative morphological characteristics of components of the varicose veins walls after sclerotherapy and endovascular laser treatment]. Kharkivska khirurhichna shkola, 4(61), 33−37. [in Ukrainian].
McAree, B. J., Ikponmwosa, A., Brockbank, K., Abbot, C., Homer-Vanniasinkam, S., & Gough, M. J. (2012). Comparative stability of sodium tetradecyl sulphate (STD) and polidocanol foam: impact on vein damage in an in-vitro model. Eur. J. Vasc. Endovasc. Surg., 43(6), 721–725. doi: 10.1016/j.ejvs.2012.02.026.
Erkin, A., Kosemehmetoglu, K., Diler, M. S., & Koksal, C. (2012). Evaluation of the minimum effective concentration of foam sclerosant in an ex-vivo study. Eur. J. Vasc. Endovasc. Surg., 44(6), 593–597. doi: 10.1016/j.ejvs.2012.09.021.
Parsi, K., Exne, T., Low, J., Ma, D. D., & Joseph, J. E. (2009). In vitro effects of detergent sclerosants on antithrombotic mechanisms. Eur. J. Vasc. Endovasc. Surg., 38 (2), 220–228. doi: 10.1016/j.ejvs.2009.03.026.
Schuller-Petrovic, S., Pavlovic, M. D., Neuhold, N., Brunner, F., & Wilkart, G. (2011). Subcutaneous injection of liquid and foamed polidocanol: extravasation is not responsible for skin necrosis during reticular and spider vein sclerotherapy. J. Eur. Acad. Dermatol. Venereol., 25(8), 983–986. doi: 10.1111/j.1468-3083.2010.03873.x.
Downloads
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (SeeThe Effect of Open Access).
