Gastric hyperplastic polyps: immunohistochemical characteristic of proliferation and apoptosis
DOI:
https://doi.org/10.14739/2310-1237.2014.3.37045Keywords:
Stomach Diseases, Polyps, Cell Proliferation, ApoptosisAbstract
Aim. In order to research proliferation and apoptosis immunohistochemical study of expression of Ki-67 and Caspase-3 inbiopsies of 42 gastric hyperplastic polyps was conducted.
Methods and results. It was found that gastric hyperplastic polyps are characterized by middle expression level of Ki-67 (2,4±0,09 points) and extremely low expression level of Casp-3 (13,6±0,392 points) in surface foveolar cells, and also low expression level of Ki-67 (0,7±0,04 points) and middle expression level of Casp-3 (61,4±9,487 points) in cells of lamina propria. In hyperplastic polyps with middle and high epithelial dysplasia expression level of Ki-67 inepithelial cells and cells of lamina propria increases.
Conclusion. These results demonstrate the leading role of cell proliferation in progression of gastric hyperplastic polyps.
References
Barannikov, K. V., Shvydkyi, Ya. B., Tumak, I. M., & Lukavetskyi, N. O. (2013) Polipy shlunka: suchasna klasyfikatsiia, endoskopichna diahnostyka, vybir taktyky [Gastric polips: current classification, endoscopic diagnosis, choice of tactics]. Lvivskyi medychnyi chasopys, 19(4), 67–75. [in Ukrainian].
Pal`cev, M. A., & Anichkov, N. M. (2005) Atlas patologii opukholej cheloveka [Atlas of pathology of human tumors]. Moscow: Medicine. [in Russian].
Han, A. R., Sung, C. O., Kim, K. M., Park, C. K., Min, B. H., Lee, L. H., et al. (2009) The clinicopathological features of gastric hyperplastic polyps with neoplastic transformations: a suggestion of indication for endoscopic polypectomy. Gut and Liver, 3(4), 271–275. doi: 10.5009/gnl.2009.3.4.271.
Spaziani, E., Picchio, M., Filippo, A., Narilli, P., Pacini, L., Moretti, V., et al. (2012) Evaluation of the oncogenic risk of diffuse gastric polyposis. A case report. Revista Espanola de Enfermedades Digestivas, 104(9), 493–496.
Goddard, A. F., Badreldin, R., & Pritchard, D. M. (2010) The management of gastric polyps. Gut, 59, 1270–1276.
Ueyama, H., Matsumoto, K., Nagahara, A., Gushima, R., Hayashi, T., Yao, Y., & Watanabe, S. (2013) A white opaque substance-positive gastric hyperplastic polyp with dysplasia. World Journal of Gastroenterology, 19(26), 4262–4266. doi: 10.3748/wjg.v19.i26.4262.
Jung, J. T. (2013) Gastric Polyps and Protruding Type Gastric Cancer. Clinical Endoscopy, 46(3), 243–247. doi: 10.5946/ce.2013.46.3.243.
Vieth, M., & Stolte, M. (2006) Evaleted risk of gastric adenocarcinoma can be predicted from histomorphology. World Journal of Gastroenterology, 12(38), 6109–6114.
Jang, H. W., Jeong, H. Y., Kim, S. H., Kang, S. H., Seong, J. K., Song, K. S., & Moon, H. S. (2013) Adenocarcinoma occurring in a gastric hyperplastic polyp treated with endoscopic submucosal dissection. Journal of Gastric Cancer, 13(2), 117–120. doi: 10.5230/jgc.2013.13.2.117.
Petrov, S. V., & Rajkhlin, N. T. (2012) Rukovodstvo po immunogisokhimicheskoj diagnostike opukholej cheloveka [Guidance on immunohistochemical diagnosis of human tumors]. Kazan`: Title. [in Russian].
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