The diagnostic and prognostic value of vascularization in papillary thyroid microcarcinomas

Authors

  • I. V. Ivakhno

DOI:

https://doi.org/10.14739/2310-1237.2015.1.42931

Keywords:

Papillary, Carcinoma, Thyroid Neoplasms, Immunohistochemistry

Abstract

Aim. Variety of clinical behavior of the thyroid microcarcinomas (PTM) is the reason for searching for the morphologic features of aggressive disease course.

Methods and results. In 22 cases of PTM immunohistochemical examination of CD34 and VEGF expression was performed to investigate the diagnostic and prognostic value of vascularization. The association between high level expression of VEGF, microvessels density and morphological features such as tumor invasion, desmoplastic stromal reaction, disorder of connective tissue maturation was revealed. The relationship between high levels of vascularization and TNM stage of disease, lymph node metastasis, extrathyroid invasion was not found.

Conclusion. Results indicate that the vascularization is a sign of growth and progression of microcarcinomas and it is not a significant predictor of the disease. 

References

Khaziev, V. V. (2013). Osoblyvosti ekspresii kolaheniv u vuzlovykh novoutvorenniakh shchytopodibnoi zalozy [Feathers of the collagen expression in nodal neoplasm of the thyroid gland]. Problemy endokrynnoi patolohii, 2, 39–45. [in Ukrainian].

Akslen, L. A. & Livolsi, V. A. (2000). Increased angiogenesis in papillary thyroid carcinoma but lack of prognostic importance. Hum. Pathol., 31, 439–42. doi:10.1053/1-ip.2000.6548.

Cappelli, C., Castellano, M., & Braga M. (2007). Aggressiveness and outcome of papillary thyroid carcinoma (PTC) versus microcarcinoma (PMC): a mono-institutional experience. J. Surg. Oncol., 95, 555–60. doi: 10.1002/jso.20746.

Сheong, H. (2010). Microvessel and Lymphatic Vessel Density and VEGFR-3 Expression of Papillary Thyroid Carcinoma with Comparative Analysis of Clinicopathological Characteristics. The Korean Journal of Pathology, 44, 243–51. doi: 10.4132/KoreanJPathol.2010.44.3.243.

Cho, J., Kim, J., & Jeong, C. (2012). Clinical features and prognostic factors in papillary thyroid microcarcinoma depends on age. J Korean Surg Soc., 82(5), 281–287. doi: 10.4174/jkss.2012.82.5.281.

He, Y. (2004). Role of lymphangiogenic factors in tumor metastasis. Biochlm Biophys Acta, 1654(1), 3–12. doi: 10.1016/j.bbcan.2003.07.003.

Koperek, O., Asari, R., Niederle, B., & Kaserer, K. (2011). Desmoplastic stromal reaction in papillary thyroid microcarcinoma. Histopathology, 58(6), 919–24. doi: 10.1111/j.1365-2559.2011.03791.x.

Liang, Q. C., Wei, Q. Y., & Fan, S. Q. (2006). Expression of VEGF-C and angiogenesis, and lymphangiogenesis in papillary thyroid carcinoma. Zhong Nan Da Xue Xue Bao Yi Xue Ban., 31, 414–416.

Lloyd, R., De Lellis, R., Heitz, P., & Eng., C. (2004). World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of the Endocrine Organs. Lyon: IARC Press International Agency for Research on Cancer.

Torre, N. G., Buley, I., Wass, J. A. & Turner, H. E. (2006) Angiogenesis and lymphangiogenesis in thyroid proliferative lesions: relationship to type and tumour behaviour. Endocr. Relat. Cancer, 13(3), 931–944. doi: 10.1677/erc.1.01210

Vong, S. & Kalluri, R. (2011). The Role of Stromal Myofibroblast and Extracellular Matrix in Tumor Angiogenesis. Genes Cancer, 2(12), 1138–1145. doi: 10.1177/1947601911423940.

Xing, M. (2007). BRAF mutation in papillary thyroid microcarcinoma: the promise of better risk management. Ann. Surg. Oncol, 28(7), 742–62. doi: 10.1245/s10434-008-0298-z.

How to Cite

1.
Ivakhno IV. The diagnostic and prognostic value of vascularization in papillary thyroid microcarcinomas. Pathologia [Internet]. 2015May19 [cited 2024Nov.24];(1). Available from: http://pat.zsmu.edu.ua/article/view/42931

Issue

Section

Original research