The indicators of the bone tissue mineralization abnormalities in women with coronary artery disease in the post-menopausal period

Authors

  • N. S. Mykhailovska Zaporizhzhia State Medical University, Ukraine,
  • I. O. Stetsiuk Zaporizhzhia State Medical University, Ukraine,

DOI:

https://doi.org/10.14739/2310-1237.2018.2.141408

Keywords:

coronary artery disease, postmenopausal period, osteoporosis, osteopenia, metabolic diseases, correlation of data.

Abstract

Objective. To determine the indicators of the bone mineral density (BMD) abnormalities in women with coronary artery disease in the post-menopausal period (СAD).

Methods. An open cross-sectional study in parallel groups involved 80 women with coronary artery disease (CAD): stable exertional angina of II–III functional class (mean age 64.59 ± 1.02 years). Depending on the degree of BMD they were divided into 3 groups: group 1 – 19 CAD women with normal BMD; group 2 – 27 CAD women with osteopenia; group 3 – 34 CAD women with osteoporosis. The control selected group consisted of 11 healthy women of the corresponding age. With the help of ultrasound densitometry, FRAX algorithm and bone biomarkers levels assessment we investigated structural and functional state of the bone tissue.

Results. It was acknowledged that in women with CAD in the postmenopausal period, depending on the severity of BMD loss, there is a significant decrease in the T- and Z-criteria and an increase in the 10-year risk of developing osteoporosis fractures. The development of postmenopausal osteoporosis (PMOS) combined with CAD was accompanied with an increase in the level of inflammation, neoangiogenesis and bone remodeling biomarkers (osteoprotegerin, ostecalcin, VEGF-A), which also have multi-directional correlative interrelationships with the structural and functional indicators of the BMD state (T, Z-criterion, 10-year risk of osteoporosis fractures). ROC-analysis results show the cut-off values at the osteopenia and osteoporosis stage for osteoprotegerin level equal to 223.76 pg/ml and 224.44 pg/ml; for osteocalcin level – 15.89 ng/ml and 16.71 ng/ml, for VEGF-A level – 112.52 pg/ml and 123.31 pg/ml correspondingly.

Conclusions. The levels of osteoprotegerin and/or ostecalcine and/or VEGF-A can be used as a screening method for early diagnosis of BMD loss and stratification of patients in the category of increased risk of osteopenia and osteoporosis.

 

References

Horbas, I. M. (2009). Ishemichna khvoroba sertsia: epidemiolohiia i statystyka [Coronary heart disease: epidemiology and statistics]. Zdorovia Ukrainy, 3/1, 34–35. [in Ukrainian].

Grasgruber, P., Sebera, M., Hrazdira, E., Hrebickova, S., & Cacek, J. (2016). Food consumption and the actual statistics of cardiovascular diseases: an epidemiological comparison of 42 European countries. Food & nutrition res., 60(1), 31694. doi: 10.3402/fnr.v60.31694.

Townsend, N., Wilson, L., Bhatnagar, P., Wickramasinghe, K., Rayner, M., & Nichols, M. (2016). Cardiovascular disease in Europe: epidemiological update 2016. Eur. Heart J., 37(42), 3232–3245. doi: 10.1093/eurheartj/ehw334.

Wilkins, E., Wilson, L., Wickramasinghe, K., Bhatnagar, P., Leal, J., Luengo-Fernandez, R., et al. (2017). European Cardiovascular Disease Statistics 2017. Brussels: European Heart Network.

Kovalenko, V. M., & Kornatskyi, V. M. (2016) Problemy zdorovia і medychnoi dopomohy tа model pokrashennia v suchasnykh umovakh [The problems of health and medical help and the improvement model in the modern conditions]. Kyiv: Hordon. [in Ukrainian].

Kovalenko, V. M., & Dorogoi, A. P. (2016) Sertsevo-sydynni khvoroby: medychno-sotsialne znachennia ta stratehiia rozvytky kardiolohii v Ukraini [Cardiovascular diseases: medical and social meaning and development strategy for cardiology in Ukraine]. Ukrainskyi kardiolohichnyi zhurnal, 3(74), 5–14. [in Ukrainian].

Fuster, K., & Kelly, B. B. (Eds.) (2010). Institute of medical committee on preventing the global epidemic of cardiovascular disease: мeeting the challenges in developing countries. Washington: National Academies Press.

Gavisova, A. A., Tverdikova, M. A., & Yakushevskaya, O. V. (2012). Osteoporoz: sovremennyj vzglyad na problemu [Osteoporoz: a modern view on a problem]. Russkij medicinskij zhurnal, 20(21), 1110–1116. [in Russian].

Povoroznyuk, V. V., Garkusha, M. A., Bystritskaya, M. A., & Balatskaya, N. I. (2012) Mineralna shilnist kistkovoi tkanyny proksimalnoho viddilu stehnovoi kistky v patsientok z perelomom Kollisa [Bone mineral density proximal femur fractures in patients with Colles’ fracture]. Problemy osteolohii, 15(4), 53–59. [in Ukrainian].

Toropcova, N. V. (2012) Shto my znaem ob e'ffectivnosti rizendronata pri osteoporoze [What do we know about rizendronate effectiveness in osteoporosis]. Zdorov'e zhenschiny, 1(67), 87–89. [in Russian].

Sagalovsky, S., & Richter, T. (2012). Patofiziologicheskoe edinstvo kletochno-molekulyarnykh mekhanizmov razvitiya osteoporoza i ateroskleroza sosudov [Pathophysiological entity of cellulomolecular mechanisms of development of osteoporosis and atherosclerosis of vessels]. Mizhnaronyi medychnyi zhurnal, 18(4), 71–78. [in Russian].

Gavisova, A. A., Tverdikova, M. A., & Yakushevskaya, O. V. (2012). Osteoporoz: sovremennyj vzglyad na problemu [Osteoporoz: a modern view on a problem]. Russkij medicinskij zhurnal, 20(21), 1110–1116. [in Russian].

Vertkin, A. L., Naumov, A. V., Goruleva, E. I., Adonina, E. V., Skotnikov, A. S., Shakirova, S. R., et al. (2012). Osteoporoz kak komponent serdechno-sosudistogo kontinuuma [Osteoporosis as component of a cardiovascular continuum]. Lechashchij vrach. Retrieved from http://www.lvrach.ru/2012/02/15435341. [in Russian].

Mykhailovska, N. S., Stetsiuk, I. O., Zelenina, O. O., & Nikitiuk, O. V. (2016). Doslidzhennia osoblyvostei sertsevo-sudynnoho remodeliuvannia ta zminy markeriv metabolizmu kistkovoi tkanyny u zhinok z ishemichnoiu khvoroboiu sertsia, asotsiiovanoiu z postmenopauzalnym osteoporozom [Research of the features of cardiovascular remodeling and bone tissue metabolism markers changes in women with coronary artery disease, associated with postmenopausal osteoporosis]. ScienceRise: Medical Science, 8(4), 51–58. [in Ukrainian].

Karpova, I. S. (2012). Vzaimosvyaz' kal'cinoza arterij i klapannogo apparata serdca i osteoporoza [Interrelation of a kaltsinoz of arteries and the valvate device of heart and Osteoporosis]. Kardiologiya v Belarusi, 1(20), 98–104. [in Russian].

Pankratova, Yu. V., Pigarova, E. A., & Dzeranova, L. K. (2013). Vitamin K-zavisimye belki: osteokal'cin, matriksnyj Gla-belok i ikh vnekostnye e'ffekty [Vitamin K-dependent proteins: osteocalcin, matrix Gla-protein, and their non-bone effects]. Ozhirenie i metabolism, 2, 11–18. [in Russian].

Zhavrid, E'. A., Antonenkova, N. N., Prokhorova, V. I., & Lappo, S. V. (2010). Koncentraciya sosudistogo e'ndotelial’nogo faktora rosta v syvorotke krovi bol’nykh metastaticheskim rakom molochnoj zhelezi i chuvstvitel’nost’ opykholi k citostaticheskoj terapii [Level of vascular endothelial growth factor in the serum of patients with metastatic breast cancer and the sensitivity of the tumor to cytostatic therapy]. Onkologicheskij zhurnal, 4, 2(14), 23–28. [in Russian].

Mohylnytska, L. A. (2015) Vaskyloendotelialnyi faktor rostu ta endoteliizalezhna dylatatsiia u khvorykh z dytynstva na tsukrovyi diabet 1 typu z mikroanhiopatiiamy ta v osib molodoho viku z ozhyrinniam [Vasculoendothelial growth factor and endothelium-dependent dilation in patients with juvenile diabetes mellitus type 1 with microangiopathies and in young patients with obesity]. Klinichna endokrynolohiia ta endokrynna khirurhiia, 3(51), 23–29. [in Ukrainian].

Grosso, A., Burger, M. G., Lunger, A., Schaefer, D. J., Banfi, A., & Di Maggio, N. (2017) It Takes Two to Tango: Coupling of Angiogenesis and Osteogenesis for Bone Regeneration. Front. Bioeng. Biotechnol., 5, 68. doi: 10.3389/fbioe.2017.00068.

Koval,’ S. N., Snegurskaya, I. A., & Mysnichenko, O. V. (2012). Semejstvo vaskuloe'ndotelial’nogo faktora rosta i ego vozmozhnaya rol’ v patogenese arterial’noj gipertenzii [Vasculoendothelial growth factor family and its possible role in the oathogenesis of arterial hypertension]. Arterial’naya gipertensiya, 4(24). Retrieved from http://www.mif-ua.com/archive/article/33320. [in Russian].

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1.
Mykhailovska NS, Stetsiuk IO. The indicators of the bone tissue mineralization abnormalities in women with coronary artery disease in the post-menopausal period. Pathologia [Internet]. 2018Sep.12 [cited 2024Mar.29];(2). Available from: http://pat.zsmu.edu.ua/article/view/141408

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Original research